Multidrug resistance proteins in rheumatoid arthritis, role in disease-modifying antirheumatic drug efficacy and inflammatory processes: an overview

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Abstract

Drug resistance is generally accepted as an important cause of treatment failure for patients with neoplastic or infectious diseases. Molecular mechanisms underlying drug resistance include the action of drug efflux pumps belonging to the super-family of ATP binding cassette (ABC) proteins, which mediate the cellular extrusion of a large variety of therapeutic drugs, a phenotype that is referred to as multidrug resistance (MDR). Unlike neoplastic and infectious diseases, chronic inflammatory diseases have received little attention. The potential role of ABC transporters in determining the efficacy of anti-rheumatic drugs, notably disease modifying anti-rheumatic drugs (DMARDs), in patients with rheumatoid arthritis is unclear. Based on knowledge from the field of oncology and immunology, this review concentrates on the pharmacological role of MDR proteins in the (clinical) efficacy of several DMARDs, as well as the physiological role of MDR proteins in transporting signalling molecules important in inflammatory processes.

Original languageEnglish
Pages (from-to)325-36
Number of pages12
JournalScandinavian Journal of Rheumatology
Volume32
Issue number6
Publication statusPublished - 2003

Cite this

@article{18a40b3b12594cb1b0e6e15dfa4580ae,
title = "Multidrug resistance proteins in rheumatoid arthritis, role in disease-modifying antirheumatic drug efficacy and inflammatory processes: an overview",
abstract = "Drug resistance is generally accepted as an important cause of treatment failure for patients with neoplastic or infectious diseases. Molecular mechanisms underlying drug resistance include the action of drug efflux pumps belonging to the super-family of ATP binding cassette (ABC) proteins, which mediate the cellular extrusion of a large variety of therapeutic drugs, a phenotype that is referred to as multidrug resistance (MDR). Unlike neoplastic and infectious diseases, chronic inflammatory diseases have received little attention. The potential role of ABC transporters in determining the efficacy of anti-rheumatic drugs, notably disease modifying anti-rheumatic drugs (DMARDs), in patients with rheumatoid arthritis is unclear. Based on knowledge from the field of oncology and immunology, this review concentrates on the pharmacological role of MDR proteins in the (clinical) efficacy of several DMARDs, as well as the physiological role of MDR proteins in transporting signalling molecules important in inflammatory processes.",
keywords = "ATP Binding Cassette Transporter, Subfamily B/drug effects, ATP Binding Cassette Transporter, Subfamily B, Member 1/analysis, ATP-Binding Cassette Transporters/drug effects, Antirheumatic Agents/administration & dosage, Arthritis, Rheumatoid/diagnosis, Biological Availability, Biological Transport, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Resistance, Multiple, Female, Humans, Inflammation Mediators/analysis, Male, Prognosis, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index, Up-Regulation",
author = "G Jansen and Scheper, {R J} and Dijkmans, {B A C}",
year = "2003",
language = "English",
volume = "32",
pages = "325--36",
journal = "Scandinavian Journal of Rheumatology",
issn = "0300-9742",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Multidrug resistance proteins in rheumatoid arthritis, role in disease-modifying antirheumatic drug efficacy and inflammatory processes

T2 - an overview

AU - Jansen, G

AU - Scheper, R J

AU - Dijkmans, B A C

PY - 2003

Y1 - 2003

N2 - Drug resistance is generally accepted as an important cause of treatment failure for patients with neoplastic or infectious diseases. Molecular mechanisms underlying drug resistance include the action of drug efflux pumps belonging to the super-family of ATP binding cassette (ABC) proteins, which mediate the cellular extrusion of a large variety of therapeutic drugs, a phenotype that is referred to as multidrug resistance (MDR). Unlike neoplastic and infectious diseases, chronic inflammatory diseases have received little attention. The potential role of ABC transporters in determining the efficacy of anti-rheumatic drugs, notably disease modifying anti-rheumatic drugs (DMARDs), in patients with rheumatoid arthritis is unclear. Based on knowledge from the field of oncology and immunology, this review concentrates on the pharmacological role of MDR proteins in the (clinical) efficacy of several DMARDs, as well as the physiological role of MDR proteins in transporting signalling molecules important in inflammatory processes.

AB - Drug resistance is generally accepted as an important cause of treatment failure for patients with neoplastic or infectious diseases. Molecular mechanisms underlying drug resistance include the action of drug efflux pumps belonging to the super-family of ATP binding cassette (ABC) proteins, which mediate the cellular extrusion of a large variety of therapeutic drugs, a phenotype that is referred to as multidrug resistance (MDR). Unlike neoplastic and infectious diseases, chronic inflammatory diseases have received little attention. The potential role of ABC transporters in determining the efficacy of anti-rheumatic drugs, notably disease modifying anti-rheumatic drugs (DMARDs), in patients with rheumatoid arthritis is unclear. Based on knowledge from the field of oncology and immunology, this review concentrates on the pharmacological role of MDR proteins in the (clinical) efficacy of several DMARDs, as well as the physiological role of MDR proteins in transporting signalling molecules important in inflammatory processes.

KW - ATP Binding Cassette Transporter, Subfamily B/drug effects

KW - ATP Binding Cassette Transporter, Subfamily B, Member 1/analysis

KW - ATP-Binding Cassette Transporters/drug effects

KW - Antirheumatic Agents/administration & dosage

KW - Arthritis, Rheumatoid/diagnosis

KW - Biological Availability

KW - Biological Transport

KW - Dose-Response Relationship, Drug

KW - Drug Administration Schedule

KW - Drug Resistance, Multiple

KW - Female

KW - Humans

KW - Inflammation Mediators/analysis

KW - Male

KW - Prognosis

KW - Risk Assessment

KW - Sensitivity and Specificity

KW - Severity of Illness Index

KW - Up-Regulation

M3 - Review article

VL - 32

SP - 325

EP - 336

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

SN - 0300-9742

IS - 6

ER -