Multiparametric MRI in a patient with adult-onset leukoencephalopathy with vanishing white matter

A. Gallo, M. A. Rocca, A. Falini, C. Scaglione, F. Salvi, A. Gambini, L. Guerrini, M. Mascalchi, J. C. Pronk, M. S. Van Der Knaap, Massimo Filippi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


This is a multiparametric MR study of the first reported patient with adult-onset genetically confirmed vanishing white matter (VWM) disease. It shows that, despite the presence of a severe and diffuse damage of the brain WM, brain gray matter, and cervical cord tissue, the cortical adaptive capacities were relatively preserved. Interpatient variability of brain plasticity may contribute to the known phenotypic variation of patients with VWM disease.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
Issue number2
Publication statusPublished - 27 Jan 2004

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