@article{7085bcacd49d47858ffd0c1c2da0e11c,
title = "Multisite assessment of aging-related tau astrogliopathy (ARTAG)",
abstract = "Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was > 60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (> 90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.",
keywords = "Aging, ARTAG, Digital pathology, Interrater agreement, Neuropathology, Tau, Tau-astrogliopathy",
author = "Kovacs, {Gabor G.} and Xie, {Sharon X.} and Lee, {Edward B.} and Robinson, {John L.} and Carrie Caswell and Irwin, {David J.} and Toledo, {Jon B.} and Johnson, {Victoria E.} and Smith, {Douglas H.} and Irina Alafuzoff and Johannes Attems and Janos Bencze and Bieniek, {Kevin F.} and Bigio, {Eileen H.} and Istvan Bodi and Herbert Budka and Dickson, {Dennis W.} and Dugger, {Brittany N.} and Charles Duyckaerts and Isidro Ferrer and Forrest, {Shelley L.} and Ellen Gelpi and Gentleman, {Stephen M.} and Giorgio Giaccone and Grinberg, {Lea T.} and Halliday, {Glenda M.} and Hatanpaa, {Kimmo J.} and Hof, {Patrick R.} and Monika Hofer and Tibor Hortob{\'a}gyi and Ironside, {James W.} and Andrew King and Julia Kofler and Enik{\"o} K{\"o}vari and Kril, {Jillian J.} and Seth Love and Mackenzie, {Ian R.} and Qinwen Mao and Radoslav Matej and Catriona McLean and Munoz, {David G.} and Murray, {Melissa E.} and Janna Neltner and Nelson, {Peter T.} and Diane Ritchie and Rodriguez, {Roberta D.} and Zdenek Rohan and Annemieke Rozemuller and Kenji Sakai and Christian Schultz and Danielle Seilhean and Vanessa Smith and Pawel Tacik and Hitoshi Takahashi and Masaki Takao and Thal, {Dietmar Rudolf} and Serge Weis and Wharton, {Stephen B.} and White, {Charles L.} and Woulfe, {John M.} and Masahito Yamada and Trojanowski, {John Q.} and {ARTAG group}",
year = "2017",
month = jan,
day = "1",
doi = "10.1093/jnen/nlx041",
language = "English",
volume = "76",
pages = "605--619",
journal = "Journal of Neuropathology and Experimental Neurology",
issn = "0022-3069",
publisher = "Lippincott Williams and Wilkins",
number = "7",
}