Abstract

Background: Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. Methods: A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue <34). Multiple linear regression analyses were conducted to study the association between SMI and CRF adjusting for relevant confounders. Results: In this group of patients with advanced cancer, the median fatigue score was 36 (interquartile range 26–44). A higher SMI on level L3 was significantly associated with less CRF for men (B 0.447, P 0.004) but not for women (B − 0.401, P 0.090). No association between SMI on level T4 and the Functional Assessment of Chronic Illness Therapy-fatigue score was found (n = 82). Conclusions: The association between SMI and CRF may lead to the suggestion that male patients may be able to reduce fatigue by exercise interventions aiming at an increased muscle mass. In women with advanced cancer, CRF is more influenced by other causes, because it is not significantly related to muscle mass. To further reduce CRF in both men and women with cancer, multifactorial assessments need to be performed in order to develop effective treatment strategies.

Original languageEnglish
Pages (from-to)623-629
Number of pages7
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Aug 2017

Cite this

@article{d727769af0a54d47986632560ea254c4,
title = "Muscle mass as a target to reduce fatigue in patients with advanced cancer",
abstract = "Background: Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. Methods: A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue <34). Multiple linear regression analyses were conducted to study the association between SMI and CRF adjusting for relevant confounders. Results: In this group of patients with advanced cancer, the median fatigue score was 36 (interquartile range 26–44). A higher SMI on level L3 was significantly associated with less CRF for men (B 0.447, P 0.004) but not for women (B − 0.401, P 0.090). No association between SMI on level T4 and the Functional Assessment of Chronic Illness Therapy-fatigue score was found (n = 82). Conclusions: The association between SMI and CRF may lead to the suggestion that male patients may be able to reduce fatigue by exercise interventions aiming at an increased muscle mass. In women with advanced cancer, CRF is more influenced by other causes, because it is not significantly related to muscle mass. To further reduce CRF in both men and women with cancer, multifactorial assessments need to be performed in order to develop effective treatment strategies.",
keywords = "Cancer, Exercise, Fatigue, Muscle, Neoplasms",
author = "Neefjes, {Elisabeth C.W.} and {van den Hurk}, {Renske M.} and Susanne Blauwhoff-Buskermolen and {van der Vorst}, {Maurice J.D.L.} and Annemarie Becker-Commissaris and {de van der Schueren}, {Marian A.E.} and Buffart, {Laurien M.} and Verheul, {Henk M.W.}",
year = "2017",
month = "8",
day = "1",
doi = "10.1002/jcsm.12199",
language = "English",
volume = "8",
pages = "623--629",
journal = "Journal of Cachexia, Sarcopenia and Muscle",
issn = "2190-5991",
publisher = "Wiley-Blackwell",
number = "4",

}

Muscle mass as a target to reduce fatigue in patients with advanced cancer. / Neefjes, Elisabeth C.W.; van den Hurk, Renske M.; Blauwhoff-Buskermolen, Susanne; van der Vorst, Maurice J.D.L.; Becker-Commissaris, Annemarie; de van der Schueren, Marian A.E.; Buffart, Laurien M.; Verheul, Henk M.W.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 8, No. 4, 01.08.2017, p. 623-629.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Muscle mass as a target to reduce fatigue in patients with advanced cancer

AU - Neefjes, Elisabeth C.W.

AU - van den Hurk, Renske M.

AU - Blauwhoff-Buskermolen, Susanne

AU - van der Vorst, Maurice J.D.L.

AU - Becker-Commissaris, Annemarie

AU - de van der Schueren, Marian A.E.

AU - Buffart, Laurien M.

AU - Verheul, Henk M.W.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. Methods: A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue <34). Multiple linear regression analyses were conducted to study the association between SMI and CRF adjusting for relevant confounders. Results: In this group of patients with advanced cancer, the median fatigue score was 36 (interquartile range 26–44). A higher SMI on level L3 was significantly associated with less CRF for men (B 0.447, P 0.004) but not for women (B − 0.401, P 0.090). No association between SMI on level T4 and the Functional Assessment of Chronic Illness Therapy-fatigue score was found (n = 82). Conclusions: The association between SMI and CRF may lead to the suggestion that male patients may be able to reduce fatigue by exercise interventions aiming at an increased muscle mass. In women with advanced cancer, CRF is more influenced by other causes, because it is not significantly related to muscle mass. To further reduce CRF in both men and women with cancer, multifactorial assessments need to be performed in order to develop effective treatment strategies.

AB - Background: Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. Methods: A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue <34). Multiple linear regression analyses were conducted to study the association between SMI and CRF adjusting for relevant confounders. Results: In this group of patients with advanced cancer, the median fatigue score was 36 (interquartile range 26–44). A higher SMI on level L3 was significantly associated with less CRF for men (B 0.447, P 0.004) but not for women (B − 0.401, P 0.090). No association between SMI on level T4 and the Functional Assessment of Chronic Illness Therapy-fatigue score was found (n = 82). Conclusions: The association between SMI and CRF may lead to the suggestion that male patients may be able to reduce fatigue by exercise interventions aiming at an increased muscle mass. In women with advanced cancer, CRF is more influenced by other causes, because it is not significantly related to muscle mass. To further reduce CRF in both men and women with cancer, multifactorial assessments need to be performed in order to develop effective treatment strategies.

KW - Cancer

KW - Exercise

KW - Fatigue

KW - Muscle

KW - Neoplasms

UR - http://www.scopus.com/inward/record.url?scp=85021189431&partnerID=8YFLogxK

U2 - 10.1002/jcsm.12199

DO - 10.1002/jcsm.12199

M3 - Article

VL - 8

SP - 623

EP - 629

JO - Journal of Cachexia, Sarcopenia and Muscle

JF - Journal of Cachexia, Sarcopenia and Muscle

SN - 2190-5991

IS - 4

ER -