Muscle wasting in male TNF-α blocker naïve ankylosing spondylitis patients: a comparison of gender differences in body composition

Sebastián Ibáñez Vodnizza, Ingrid M. Visman, Christiaan van Denderen, Willem F. Lems, Francisca Jaime, Michael T. Nurmohamed, Irene E. van der Horst-Bruinsma

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To assess gender differences in body composition (BC) in a cohort of AS patients naïve to TNF-α blockers.

Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF%), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles).

Results: Seventy consecutive patients were included; 60% were men. Demographic variables were similar, except for dyslipidaemia (57.1% of men; 14.3% of women). Women had significantly more fat (BF%, FMI), and less muscle (FFMI) than men, but below the median of the reference population. Male AS patients had a markedly low FFMI (31.7th percentile) compared with the reference population. In the whole group, after multivariate analysis, an ASDAS CRP >3.5 was related to lower fat free mass content. In men, a significant relationship between having a high disease activity (ASDAS, BASDAI) and lower BF% or FMI percentile was found, but in women it was the opposite.

Conclusion: Muscle wasting, measured as low FFMI compared with the reference population, was found in male TNF-α blocker naïve AS patients, especially in those with active disease. Women had higher volumes of body fat than men, but near the median of the reference population. The relationships between fat content and disease activity support the complex association between adipose tissue and inflammation.

Original languageEnglish
Pages (from-to)1566-1572
Number of pages7
JournalRheumatology (Oxford, England)
Volume56
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

Cite this

@article{1716ea5ebc384a45885954b26ca7a45e,
title = "Muscle wasting in male TNF-α blocker na{\"i}ve ankylosing spondylitis patients: a comparison of gender differences in body composition",
abstract = "Objective: To assess gender differences in body composition (BC) in a cohort of AS patients na{\"i}ve to TNF-α blockers.Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF{\%}), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles).Results: Seventy consecutive patients were included; 60{\%} were men. Demographic variables were similar, except for dyslipidaemia (57.1{\%} of men; 14.3{\%} of women). Women had significantly more fat (BF{\%}, FMI), and less muscle (FFMI) than men, but below the median of the reference population. Male AS patients had a markedly low FFMI (31.7th percentile) compared with the reference population. In the whole group, after multivariate analysis, an ASDAS CRP >3.5 was related to lower fat free mass content. In men, a significant relationship between having a high disease activity (ASDAS, BASDAI) and lower BF{\%} or FMI percentile was found, but in women it was the opposite.Conclusion: Muscle wasting, measured as low FFMI compared with the reference population, was found in male TNF-α blocker na{\"i}ve AS patients, especially in those with active disease. Women had higher volumes of body fat than men, but near the median of the reference population. The relationships between fat content and disease activity support the complex association between adipose tissue and inflammation.",
keywords = "ankylosing spondylitis, body composition, dual-energy X-ray absorptiometry, muscle wasting",
author = "{Ib{\'a}{\~n}ez Vodnizza}, Sebasti{\'a}n and Visman, {Ingrid M.} and {van Denderen}, Christiaan and Lems, {Willem F.} and Francisca Jaime and Nurmohamed, {Michael T.} and {van der Horst-Bruinsma}, {Irene E.}",
year = "2017",
month = "9",
day = "1",
doi = "10.1093/rheumatology/kex187",
language = "English",
volume = "56",
pages = "1566--1572",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "9",

}

Muscle wasting in male TNF-α blocker naïve ankylosing spondylitis patients : a comparison of gender differences in body composition. / Ibáñez Vodnizza, Sebastián; Visman, Ingrid M.; van Denderen, Christiaan; Lems, Willem F.; Jaime, Francisca; Nurmohamed, Michael T.; van der Horst-Bruinsma, Irene E.

In: Rheumatology (Oxford, England), Vol. 56, No. 9, 01.09.2017, p. 1566-1572.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Muscle wasting in male TNF-α blocker naïve ankylosing spondylitis patients

T2 - a comparison of gender differences in body composition

AU - Ibáñez Vodnizza, Sebastián

AU - Visman, Ingrid M.

AU - van Denderen, Christiaan

AU - Lems, Willem F.

AU - Jaime, Francisca

AU - Nurmohamed, Michael T.

AU - van der Horst-Bruinsma, Irene E.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Objective: To assess gender differences in body composition (BC) in a cohort of AS patients naïve to TNF-α blockers.Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF%), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles).Results: Seventy consecutive patients were included; 60% were men. Demographic variables were similar, except for dyslipidaemia (57.1% of men; 14.3% of women). Women had significantly more fat (BF%, FMI), and less muscle (FFMI) than men, but below the median of the reference population. Male AS patients had a markedly low FFMI (31.7th percentile) compared with the reference population. In the whole group, after multivariate analysis, an ASDAS CRP >3.5 was related to lower fat free mass content. In men, a significant relationship between having a high disease activity (ASDAS, BASDAI) and lower BF% or FMI percentile was found, but in women it was the opposite.Conclusion: Muscle wasting, measured as low FFMI compared with the reference population, was found in male TNF-α blocker naïve AS patients, especially in those with active disease. Women had higher volumes of body fat than men, but near the median of the reference population. The relationships between fat content and disease activity support the complex association between adipose tissue and inflammation.

AB - Objective: To assess gender differences in body composition (BC) in a cohort of AS patients naïve to TNF-α blockers.Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF%), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles).Results: Seventy consecutive patients were included; 60% were men. Demographic variables were similar, except for dyslipidaemia (57.1% of men; 14.3% of women). Women had significantly more fat (BF%, FMI), and less muscle (FFMI) than men, but below the median of the reference population. Male AS patients had a markedly low FFMI (31.7th percentile) compared with the reference population. In the whole group, after multivariate analysis, an ASDAS CRP >3.5 was related to lower fat free mass content. In men, a significant relationship between having a high disease activity (ASDAS, BASDAI) and lower BF% or FMI percentile was found, but in women it was the opposite.Conclusion: Muscle wasting, measured as low FFMI compared with the reference population, was found in male TNF-α blocker naïve AS patients, especially in those with active disease. Women had higher volumes of body fat than men, but near the median of the reference population. The relationships between fat content and disease activity support the complex association between adipose tissue and inflammation.

KW - ankylosing spondylitis

KW - body composition

KW - dual-energy X-ray absorptiometry

KW - muscle wasting

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U2 - 10.1093/rheumatology/kex187

DO - 10.1093/rheumatology/kex187

M3 - Article

VL - 56

SP - 1566

EP - 1572

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 9

ER -