Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis

Research output: Contribution to journalArticleAcademicpeer-review

204 Downloads (Pure)


OBJECTIVE: The aim of this study was to investigate whether there are differences in capillary nailfold changes in patients with systemic sclerosis (SSc) with and without pulmonary arterial hypertension (PAH), and whether these changes are associated with PAH severity and disease specificity. METHODS: Capillary density and loop dimensions were studied in 21 healthy controls, 20 patients with idiopathic PAH (IPAH) and 40 patients with SSc. Of the 40 patients with SSc, 19 had no PAH (SSc-nonPAH) and 21 had PAH (SSc-PAH), of whom eight had PAH during exercise. RESULTS: Capillary density was lower in SSc-PAH compared with patients who had SSc-nonPAH (4.33/mm vs 6.56/mm respectively, p = 0.001), but loop dimensions were equal. In comparison with IPAH, patients with SSc-PAH had reduced capillary density (4.33/mm vs 7.86/mm, p
Original languageUndefined/Unknown
Pages (from-to)191-195
Number of pages6
JournalAnnals of the Rheumatic Diseases
Issue number2
Publication statusPublished - 2009

Cite this