@article{64027e965ccc42978c4e49dd40513e87,
title = "Natural killer cells and anti-cancer therapies: Reciprocal effects on immune function and therapeutic response",
abstract = "Natural Killer (NK) cells are innate immune cells with the unique ability to recognize and kill virus-infected and cancer cells without prior immune sensitization. Due to their expression of the Fc receptor CD16, effector NK cells can kill tumor cells through antibody-dependent cytotoxicity, making them relevant players in antibody-based cancer therapies. The role of NK cells in other approved and experimental anti-cancer therapies is more elusive. Here, we review the possible role of NK cells in the efficacy of various anti-tumor therapies, including radiotherapy, chemotherapy, and immunotherapy, as well as the impact of these therapies on NK cell function.",
keywords = "Anti-cancer therapies, Cancer, Checkpoint inhibitors, Chemotherapy, Local ablation therapies, NK cells, Oncolytic virus, Protein kinase inhibitors, Radiotherapy",
author = "Toffoli, {Elisa C.} and Abdolkarim Sheikhi and H{\"o}ppner, {Yannick D.} and {de Kok}, Pita and Mahsa Yazdanpanah-Samani and Jan Spanholtz and Verheul, {Henk M.W.} and {van der Vliet}, {Hans J.} and {de Gruijl}, {Tanja D.}",
note = "Funding Information: Funding: This work was supported by a research grant from Glycostem BV and a grant (DUMS-1397-3-19-1121) from the Dezful University of Medical Sciences. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
day = "2",
doi = "10.3390/cancers13040711",
language = "English",
volume = "13",
pages = "1--27",
journal = "Cancers (Basel)",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",
}