Neonatal neural networks predict children behavioral profiles later in life

Chong-Yaw Wee, Ta Anh Tuan, Birit F P Broekman, Min Yee Ong, Yap-Seng Chong, Kenneth Kwek, Lynette Pei-Chi Shek, Seang-Mei Saw, Peter D Gluckman, Marielle V Fortier, Michael J Meaney, Anqi Qiu

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This study aimed to examine heterogeneity of neonatal brain network and its prediction to child behaviors at 24 and 48 months of age. Diffusion tensor imaging (DTI) tractography was employed to construct brain anatomical network for 120 neonates. Clustering coefficients of individual structures were computed and used to classify neonates with similar brain anatomical networks into one group. Internalizing and externalizing behavioral problems were assessed using maternal reports of the Child Behavior Checklist (CBCL) at 24 and 48 months of age. The profile of CBCL externalizing and internalizing behaviors was then examined in the groups identified based on the neonatal brain network. Finally, support vector machine and canonical correlation analysis were used to identify brain structures whose clustering coefficients together significantly contribute the variation of the behaviors at 24 and 48 months of age. Four meaningful groups were revealed based on the brain anatomical networks at birth. Moreover, the clustering coefficients of the brain regions that most contributed to this grouping of neonates were significantly associated with childhood internalizing and externalizing behaviors assessed at 24 and 48 months of age. Specially, the clustering coefficient of the right amygdala was associated with both internalizing and externalizing behaviors at 24 months of age, while the clustering coefficients of the right inferior frontal cortex and insula were associated with externalizing behaviors at 48 months of age. Our findings suggested that neural organization established during fetal development could to some extent predict individual differences in behavioral-emotional problems in early childhood. Hum Brain Mapp 38:1362-1373, 2017. © 2016 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)1362-1373
Number of pages12
JournalHuman Brain Mapping
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 2017
Externally publishedYes

Cite this

Wee, C-Y., Tuan, T. A., Broekman, B. F. P., Ong, M. Y., Chong, Y-S., Kwek, K., ... Qiu, A. (2017). Neonatal neural networks predict children behavioral profiles later in life. Human Brain Mapping, 38(3), 1362-1373. https://doi.org/10.1002/hbm.23459