Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description

P. L.M. Kerkhof*, M. F. Weber, J. L.J. Vanoverschelde, C. P. Cheng

*Corresponding author for this work

Research output: Contribution to conferencePaperAcademic

Abstract

The aim of this study is to analyze the relation between myocardial oxygen consumption (MVO2) and end-systolic volume (ESV) in dependence of adrenergic stimulation or blockade in the normal left ventricle. We analyzed MVO2 and volumetric data of five chronically instrumented dogs measured during rest and exercise, while protocols were performed with and without beta-blockade. Then we constructed their overall Alternative Starling Curve (ASC) by plotting ESV versus end-diastolic volume (EDV). Subsequently, we carried out an analysis, while employing an extended model compared with the Pressure-Volume-Area (PVA) for MVO2 prediction as originally proposed by Suga. This mathematical model is validated by comparison with pertinent data obtained by labeled C-acetate PET studies in healthy humans. Our results indicate a close resemblance between theoretically predicted MVO2 data and actual measurements performed in humans and dogs. In addition, this study suggests neural modulation of the MVO2-ESV relationship by illustrating the effects of various adrenergic interventions.

Original languageEnglish
Pages115-116
Number of pages2
Publication statusPublished - 1 Dec 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: 20 Sep 199523 Sep 1995

Conference

ConferenceProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)
CityMontreal, Can
Period20/09/199523/09/1995

Cite this

Kerkhof, P. L. M., Weber, M. F., Vanoverschelde, J. L. J., & Cheng, C. P. (1995). Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description. 115-116. Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can, .