Neurobehavioural outcome in 6–18 year old children after trauma in pregnancy: Case–control study

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Maternal trauma complicates pregnancy in approximately 7%. Long-term development of children exposed to maternal trauma is unknown. Aim: To determine neurobehavioural outcome of children (6–18 years) born after maternal trauma in pregnancy compared to a matched control group. Study design: Case-control study performed at a tertiary medical centre. Subjects: All consecutive children born after maternal hospitalization for trauma during pregnancy between 1995 and 2005. Controls were children born at the same hospital and period after an uneventful pregnancy. Outcome measures: Trauma type and severity (Injury Severity Score, ≥9: severe); information from medical files at admission (cases). All mothers filled out two questionnaires about the infant; 1. concerning health, motor development and educational level, 2. concerning behavioural development through the validated Dutch version of the Child Behavior Checklist (CBCL). Results: Questionnaires were returned by 34 cases and 28 controls. The traumas concerned mainly motor vehicle accidents and falls, and 3/34 had severe injuries. No differences in health, motor development, educational level and CBCL was found between the cases and controls, except for more hospitalization in the cases (p = 0.009). Conclusion: Long-term follow-up of a limited population of children 6–18 years after exposure of mainly non-severe trauma before birth is similar to a control population except for unexplained more hospitalization in the cases.

LanguageEnglish
Pages845-853
Number of pages9
JournalEuropean Journal of Paediatric Neurology
Volume22
Issue number5
DOIs
Publication statusPublished - 1 Sep 2018

Cite this

@article{e478912fb12847e09396fc8f0684bc09,
title = "Neurobehavioural outcome in 6–18 year old children after trauma in pregnancy: Case–control study",
abstract = "Background: Maternal trauma complicates pregnancy in approximately 7{\%}. Long-term development of children exposed to maternal trauma is unknown. Aim: To determine neurobehavioural outcome of children (6–18 years) born after maternal trauma in pregnancy compared to a matched control group. Study design: Case-control study performed at a tertiary medical centre. Subjects: All consecutive children born after maternal hospitalization for trauma during pregnancy between 1995 and 2005. Controls were children born at the same hospital and period after an uneventful pregnancy. Outcome measures: Trauma type and severity (Injury Severity Score, ≥9: severe); information from medical files at admission (cases). All mothers filled out two questionnaires about the infant; 1. concerning health, motor development and educational level, 2. concerning behavioural development through the validated Dutch version of the Child Behavior Checklist (CBCL). Results: Questionnaires were returned by 34 cases and 28 controls. The traumas concerned mainly motor vehicle accidents and falls, and 3/34 had severe injuries. No differences in health, motor development, educational level and CBCL was found between the cases and controls, except for more hospitalization in the cases (p = 0.009). Conclusion: Long-term follow-up of a limited population of children 6–18 years after exposure of mainly non-severe trauma before birth is similar to a control population except for unexplained more hospitalization in the cases.",
keywords = "Case–control, Maternal injuries, Neurobehavioural outcome, Trauma in pregnancy",
author = "{van der Knoop}, {B. J.} and Oostrom, {K. J.} and Zonnenberg, {I. A.} and {van Weissenbruch}, {M. M.} and Vermeulen, {R. J.} and {de Vries}, {J. I.P.}",
year = "2018",
month = "9",
day = "1",
doi = "10.1016/j.ejpn.2018.04.004",
language = "English",
volume = "22",
pages = "845--853",
journal = "European Journal of Paediatric Neurology",
issn = "1090-3798",
publisher = "W.B. Saunders Ltd",
number = "5",

}

Neurobehavioural outcome in 6–18 year old children after trauma in pregnancy : Case–control study. / van der Knoop, B. J.; Oostrom, K. J.; Zonnenberg, I. A.; van Weissenbruch, M. M.; Vermeulen, R. J.; de Vries, J. I.P.

In: European Journal of Paediatric Neurology, Vol. 22, No. 5, 01.09.2018, p. 845-853.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Neurobehavioural outcome in 6–18 year old children after trauma in pregnancy

T2 - European Journal of Paediatric Neurology

AU - van der Knoop, B. J.

AU - Oostrom, K. J.

AU - Zonnenberg, I. A.

AU - van Weissenbruch, M. M.

AU - Vermeulen, R. J.

AU - de Vries, J. I.P.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Maternal trauma complicates pregnancy in approximately 7%. Long-term development of children exposed to maternal trauma is unknown. Aim: To determine neurobehavioural outcome of children (6–18 years) born after maternal trauma in pregnancy compared to a matched control group. Study design: Case-control study performed at a tertiary medical centre. Subjects: All consecutive children born after maternal hospitalization for trauma during pregnancy between 1995 and 2005. Controls were children born at the same hospital and period after an uneventful pregnancy. Outcome measures: Trauma type and severity (Injury Severity Score, ≥9: severe); information from medical files at admission (cases). All mothers filled out two questionnaires about the infant; 1. concerning health, motor development and educational level, 2. concerning behavioural development through the validated Dutch version of the Child Behavior Checklist (CBCL). Results: Questionnaires were returned by 34 cases and 28 controls. The traumas concerned mainly motor vehicle accidents and falls, and 3/34 had severe injuries. No differences in health, motor development, educational level and CBCL was found between the cases and controls, except for more hospitalization in the cases (p = 0.009). Conclusion: Long-term follow-up of a limited population of children 6–18 years after exposure of mainly non-severe trauma before birth is similar to a control population except for unexplained more hospitalization in the cases.

AB - Background: Maternal trauma complicates pregnancy in approximately 7%. Long-term development of children exposed to maternal trauma is unknown. Aim: To determine neurobehavioural outcome of children (6–18 years) born after maternal trauma in pregnancy compared to a matched control group. Study design: Case-control study performed at a tertiary medical centre. Subjects: All consecutive children born after maternal hospitalization for trauma during pregnancy between 1995 and 2005. Controls were children born at the same hospital and period after an uneventful pregnancy. Outcome measures: Trauma type and severity (Injury Severity Score, ≥9: severe); information from medical files at admission (cases). All mothers filled out two questionnaires about the infant; 1. concerning health, motor development and educational level, 2. concerning behavioural development through the validated Dutch version of the Child Behavior Checklist (CBCL). Results: Questionnaires were returned by 34 cases and 28 controls. The traumas concerned mainly motor vehicle accidents and falls, and 3/34 had severe injuries. No differences in health, motor development, educational level and CBCL was found between the cases and controls, except for more hospitalization in the cases (p = 0.009). Conclusion: Long-term follow-up of a limited population of children 6–18 years after exposure of mainly non-severe trauma before birth is similar to a control population except for unexplained more hospitalization in the cases.

KW - Case–control

KW - Maternal injuries

KW - Neurobehavioural outcome

KW - Trauma in pregnancy

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U2 - 10.1016/j.ejpn.2018.04.004

DO - 10.1016/j.ejpn.2018.04.004

M3 - Article

VL - 22

SP - 845

EP - 853

JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

SN - 1090-3798

IS - 5

ER -