Adrian Van Der Kleij, Peter Sminia

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Hypoxia is recognized as a major cause of failure of radiotherapy. In clinical oncology, several treatment modalities have been applied to overcome tumour hypoxia either by increasing the oxygen delivery to tumour cells (ie carbogen and hyperbaric oxygen) or by combined treatment with oxygen mimicking agents to sensitize hypoxic cells (ie misonidazole). Radiation enhancement by HBO in the treatment of patients with recurrent Neuroblastoma stage IV in a setting of unsealed source radionuclide brachytherapy seems to be the most promising indication of that approach

Original languageEnglish
Title of host publicationHandbook on Hyperbaric Medicine
PublisherSpringer Netherlands
Number of pages7
ISBN (Electronic)9781402044489
ISBN (Print)1402043767, 9781402043765
Publication statusPublished - 1 Jan 2006

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