Neurodevelopmental outcome after neonatal perforator stroke

Ginette M. Ecury-Goossen, Marit van der Haer, Liesbeth S. Smit, Monique Feijen-Roon, Maarten Lequin, Rogier C.J. de Jonge, Paul Govaert, Jeroen Dudink*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aim: To assess outcome after neonatal perforator stroke in the largest cohort to date. Method: Survivors from a cohort of children diagnosed with neonatal perforator stroke using cranial ultrasound or magnetic resonance imaging were eligible for inclusion. Recovery and Recurrence Questionnaire score, presence of cerebral palsy (CP), and crude outcome were assessed, specifically (1) the ability to walk independently, (2) participation in regular education, and (3) the presence of epilepsy. Results: Thirty-seven patients (20 males, 17 females) aged 3 to 14 years (mean age 8y) were included in the study: 14 with isolated single perforator stroke, four with multiple isolated perforator strokes, and 19 with additional brain injury. Out of 18 children with isolated perforator stroke(s), four had CP, one could not walk independently, and one developed epilepsy. The posterior limb of the internal capsule was involved in four out of 18 patients; three of these patients had CP. Of 19 children with additional brain injury, 11 had CP and three were not able to walk independently. Three out of nine children with concomitant cortical middle cerebral artery stroke developed epilepsy. Interpretation: Perforator stroke patterns can be of use in predicting long-term outcome and for guiding counselling and surveillance. Motor outcome was favourable in children with isolated perforator stroke(s), except when the posterior limb of the internal capsule was involved.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalDevelopmental Medicine and Child Neurology
Volume58
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Cite this

Ecury-Goossen, G. M., van der Haer, M., Smit, L. S., Feijen-Roon, M., Lequin, M., de Jonge, R. C. J., ... Dudink, J. (2016). Neurodevelopmental outcome after neonatal perforator stroke. Developmental Medicine and Child Neurology, 58(1), 49-56. https://doi.org/10.1111/dmcn.12857