Neuroimaging and correlates of cognitive function among patients with heart failure

Raymond L.C. Vogels, Joukje M. Oosterman, Barbera Van Harten, Alida A. Gouw, Jutta M. Schroeder-Tanka, Philip Scheltens, Wiesje M. Van Der Flier, Henry C. Weinstein

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background/Aims: We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). Methods: In 58 patients with HF neuropsychological assessment was performed including tests of mental speed, executive functions, memory, language and visuospatial functions. Deep, periventricular and total white matter hyperintensities (WMH), lacunar and cortical infarcts, global and medial temporal lobe atrophy (MTA) were investigated on MRI of the brain. Correlations between MRI findings and the cognitive measures were calculated. Results: MTA correlated with memory (r = -0.353, p < 0.01), with executive functions (r = -0.383, p < 0.01) and the Mini Mental State Examination (r = -0.343, p < 0.05). Total WMH and deep WMH were found to correlate with depression and anxiety scores, but not with cognitive measures. Age, estimated premorbid intelligence and MTA were independent predictors of diminished cognitive performance. Conclusions: In HF patients, MTA was related to cognitive dysfunction, involving memory impairment and executive dysfunction, whereas WMH was related to depression and anxiety.

Original languageEnglish
Pages (from-to)418-423
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume24
Issue number6
DOIs
Publication statusPublished - 1 Nov 2007

Cite this

Vogels, R. L. C., Oosterman, J. M., Van Harten, B., Gouw, A. A., Schroeder-Tanka, J. M., Scheltens, P., ... Weinstein, H. C. (2007). Neuroimaging and correlates of cognitive function among patients with heart failure. Dementia and Geriatric Cognitive Disorders, 24(6), 418-423. https://doi.org/10.1159/000109811
Vogels, Raymond L.C. ; Oosterman, Joukje M. ; Van Harten, Barbera ; Gouw, Alida A. ; Schroeder-Tanka, Jutta M. ; Scheltens, Philip ; Van Der Flier, Wiesje M. ; Weinstein, Henry C. / Neuroimaging and correlates of cognitive function among patients with heart failure. In: Dementia and Geriatric Cognitive Disorders. 2007 ; Vol. 24, No. 6. pp. 418-423.
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Neuroimaging and correlates of cognitive function among patients with heart failure. / Vogels, Raymond L.C.; Oosterman, Joukje M.; Van Harten, Barbera; Gouw, Alida A.; Schroeder-Tanka, Jutta M.; Scheltens, Philip; Van Der Flier, Wiesje M.; Weinstein, Henry C.

In: Dementia and Geriatric Cognitive Disorders, Vol. 24, No. 6, 01.11.2007, p. 418-423.

Research output: Contribution to journalArticleAcademicpeer-review

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