Neuroinflammation: From target selection to preclinical and clinical studies

Bastian Zinnhardt, Cristina Barca, Claudia Foray, Inga B. Fricke, Thomas Viel, Alexandra Winkeler, Albert D. Windhorst, Andreas H. Jacobs*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis in neurological disorders and often serves as a prognostic marker for disease outcome. The underlying cellular and factorial heterogeneity represents an opportunity in the development of disease-modifying therapies. Molecular imaging of neuroinflammation (NI) may support the characterization of key aspects of the dynamic interplay of various inducers, sensors, transducers, and effectors of the multifactorial inflammatory response in vivo in animal models and patients. The characterization of the NI response by molecular imaging will (i) support early diagnosis and disease follow-up, (ii) guide (stereotactic) biopsy sampling, (iii) highlight the dynamic changes during disease pathogenesis in a noninvasive manner, (iv) help monitoring existing therapies, (v) support the development of novel NI-modifying therapies, and (vi) aid stratification of patients, according to their individual NI profile. This book chapter will review the basic principles of NI, recent developments and applications of novel molecular imaging targets, key considerations for the selection and development of imaging targets, as well as examples of successful clinical translation of NI imaging.
Original languageEnglish
Title of host publicationPET and SPECT of Neurobiological Systems
PublisherSpringer International Publishing
ISBN (Electronic)9783030531768
ISBN (Print)9783030531751
Publication statusPublished - 29 Sept 2020

Publication series

NamePET and SPECT of Neurobiological Systems

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