Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb

Anne Vroon, Benjamin Drukarch, John G J M Bol, Patrick Cras, John J P Brevé, Stuart M Allan, Jane K Relton, Piet V J M Hoogland, Anne-Marie Van Dam

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of PD patients. Also in olfactory bulb of MPTP-treated mice, microgliosis and increased expression of IL-1alpha, IL-1beta and IL-1ra mRNA was observed early after treatment. These observations implicate that neuroinflammation is not restricted to the nigrostriatal system. MPTP-induced microgliosis in striatum and olfactory bulb was reduced in IL-1alpha/beta knockout mice, indicating that IL-1 affects microglia activation. Importantly, MPTP induced differential regulation of IL-1 receptors. mRNA levels of IL-1RI and, to a lesser extent, IL-1RII were increased in striatum. Interestingly, in the olfactory bulb only IL-1RII mRNA was enhanced. We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD.

Original languageEnglish
Pages (from-to)762-71
Number of pages10
JournalExperimental Gerontology
Volume42
Issue number8
DOIs
Publication statusPublished - Aug 2007

Cite this

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title = "Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb",
abstract = "Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of PD patients. Also in olfactory bulb of MPTP-treated mice, microgliosis and increased expression of IL-1alpha, IL-1beta and IL-1ra mRNA was observed early after treatment. These observations implicate that neuroinflammation is not restricted to the nigrostriatal system. MPTP-induced microgliosis in striatum and olfactory bulb was reduced in IL-1alpha/beta knockout mice, indicating that IL-1 affects microglia activation. Importantly, MPTP induced differential regulation of IL-1 receptors. mRNA levels of IL-1RI and, to a lesser extent, IL-1RII were increased in striatum. Interestingly, in the olfactory bulb only IL-1RII mRNA was enhanced. We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD.",
keywords = "Animals, Base Sequence, Corpus Striatum, DNA Primers, Gene Expression, Humans, MPTP Poisoning, Male, Mice, Mice, Inbred C57BL, Microglia, Olfactory Bulb, Parkinson Disease, Parkinsonian Disorders, Receptors, Interleukin-1, Substantia Nigra, Journal Article, Research Support, Non-U.S. Gov't",
author = "Anne Vroon and Benjamin Drukarch and Bol, {John G J M} and Patrick Cras and Brev{\'e}, {John J P} and Allan, {Stuart M} and Relton, {Jane K} and Hoogland, {Piet V J M} and {Van Dam}, Anne-Marie",
year = "2007",
month = "8",
doi = "10.1016/j.exger.2007.04.010",
language = "English",
volume = "42",
pages = "762--71",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",
number = "8",

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TY - JOUR

T1 - Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system

T2 - microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb

AU - Vroon, Anne

AU - Drukarch, Benjamin

AU - Bol, John G J M

AU - Cras, Patrick

AU - Brevé, John J P

AU - Allan, Stuart M

AU - Relton, Jane K

AU - Hoogland, Piet V J M

AU - Van Dam, Anne-Marie

PY - 2007/8

Y1 - 2007/8

N2 - Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of PD patients. Also in olfactory bulb of MPTP-treated mice, microgliosis and increased expression of IL-1alpha, IL-1beta and IL-1ra mRNA was observed early after treatment. These observations implicate that neuroinflammation is not restricted to the nigrostriatal system. MPTP-induced microgliosis in striatum and olfactory bulb was reduced in IL-1alpha/beta knockout mice, indicating that IL-1 affects microglia activation. Importantly, MPTP induced differential regulation of IL-1 receptors. mRNA levels of IL-1RI and, to a lesser extent, IL-1RII were increased in striatum. Interestingly, in the olfactory bulb only IL-1RII mRNA was enhanced. We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD.

AB - Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of PD patients. Also in olfactory bulb of MPTP-treated mice, microgliosis and increased expression of IL-1alpha, IL-1beta and IL-1ra mRNA was observed early after treatment. These observations implicate that neuroinflammation is not restricted to the nigrostriatal system. MPTP-induced microgliosis in striatum and olfactory bulb was reduced in IL-1alpha/beta knockout mice, indicating that IL-1 affects microglia activation. Importantly, MPTP induced differential regulation of IL-1 receptors. mRNA levels of IL-1RI and, to a lesser extent, IL-1RII were increased in striatum. Interestingly, in the olfactory bulb only IL-1RII mRNA was enhanced. We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD.

KW - Animals

KW - Base Sequence

KW - Corpus Striatum

KW - DNA Primers

KW - Gene Expression

KW - Humans

KW - MPTP Poisoning

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Microglia

KW - Olfactory Bulb

KW - Parkinson Disease

KW - Parkinsonian Disorders

KW - Receptors, Interleukin-1

KW - Substantia Nigra

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.exger.2007.04.010

DO - 10.1016/j.exger.2007.04.010

M3 - Article

VL - 42

SP - 762

EP - 771

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

IS - 8

ER -