Neuroinflammation: Microglia and T Cells Get Ready to Tango

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.
Original languageEnglish
Article number1905
JournalFrontiers in Immunology
Volume8
Issue numberJAN
DOIs
Publication statusPublished - 2018

Cite this

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title = "Neuroinflammation: Microglia and T Cells Get Ready to Tango",
abstract = "In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.",
author = "Schetters, {Sjoerd T. T.} and Diego Gomez-Nicola and Garcia-Vallejo, {Juan J.} and {van Kooyk}, Yvette",
year = "2018",
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language = "English",
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journal = "Frontiers in Immunology: Molecular Innate Immunity",
issn = "1664-3224",
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}

Neuroinflammation : Microglia and T Cells Get Ready to Tango. / Schetters, Sjoerd T. T.; Gomez-Nicola, Diego; Garcia-Vallejo, Juan J.; van Kooyk, Yvette.

In: Frontiers in Immunology, Vol. 8, No. JAN, 1905, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

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T2 - Microglia and T Cells Get Ready to Tango

AU - Schetters, Sjoerd T. T.

AU - Gomez-Nicola, Diego

AU - Garcia-Vallejo, Juan J.

AU - van Kooyk, Yvette

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