Neurological recovery after traumatic spinal cord injury: what is meaningful? A patients' and physicians' perspective

Paula Valerie Ter Wengel, Marcel W M Post, Enrico Martin, Janneke Stolwijk-Swuste, Allard Jan Frederik Hosman, Said Sadiqi, William Peter Vandertop, Fetullah Cumhur Öner

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Abstract

STUDY DESIGN: Cross-sectional survey.

OBJECTIVES: Most studies on neurological recovery after traumatic spinal cord injury (tSCI) assess treatment effects using the American Spinal Injury Association Impairment Scale (AIS grade) or motor points recovery. To what extent neurological recovery is considered clinically meaningful is unknown. This study investigated the perceived clinical benefit of various degrees of neurological recovery one year after C5 AIS-A tSCI.

SETTING: The Netherlands.

METHODS: By means of a web-based survey SCI patients and physicians evaluated the benefit of various scenarios of neurological recovery on a scale from 0 to 100% (0% no benefit to 100% major benefit). Recovery to AIS-C and D, was split into C/C+ and D/D+, which was defined by the lower and upper limit of recovery for each grade.

RESULTS: A total of 79 patients and 77 physicians participated in the survey. Each AIS grade improvement from AIS-A was considered significant benefit (all p < 0.05), ranging from 47.8% (SD 26.1) for AIS-B to 86.8% (SD 24.3) for AIS-D+. Motor level lowering was also considered significant benefit (p < 0.05), ranging from 66.1% (SD 22.3) for C6 to 81.7% (SD 26.0) for C8.

CONCLUSIONS: Meaningful recovery can be achieved without improving in AIS grade, since the recovery of functional motor levels appears to be as important as improving in AIS grade by both patients and physicians. Moreover, minor neurological improvements within AIS-C and D are also considered clinically meaningful. Future studies should incorporate more detailed neurological outcomes to prevent potential underestimation of neurological recovery by only using the AIS grade.

Original languageEnglish
JournalSpinal Cord
DOIs
Publication statusE-pub ahead of print - 17 Feb 2020

Cite this

Ter Wengel, P. V., Post, M. W. M., Martin, E., Stolwijk-Swuste, J., Hosman, A. J. F., Sadiqi, S., ... Öner, F. C. (2020). Neurological recovery after traumatic spinal cord injury: what is meaningful? A patients' and physicians' perspective. Spinal Cord. https://doi.org/10.1038/s41393-020-0436-4