Neuromyelitis optica spectrum disorder mimicking multiple sclerosis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background MS is a demyelinating CNS disease and has distinct clinical and radiological features. Neuromyelitis optica spectrum disorder (NMOSD) is an antibody related auto-immune disease known for invalidating episodes of myelitis and optic neuritis. Objective Reporting the case of a 29-year old woman with a disease course typical for relapsing remitting MS with consistent radiological and spinal fluid findings, who developed longitudinally extensive transverse myelitis (LETM) with positive aquaporin 4 antibodies, fulfilling the diagnostic criteria for NMOSD. Methods Case report. Results LETM is not consistent with MS. Consider NMOSD even in patients with typical MS and check for aquaporin-4 antibodies, with important treatment consequences.

Original languageEnglish
Pages (from-to)54-56
Number of pages3
JournalMultiple Sclerosis and Related Disorders
Volume17
DOIs
Publication statusPublished - 1 Oct 2017

Cite this

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title = "Neuromyelitis optica spectrum disorder mimicking multiple sclerosis",
abstract = "Background MS is a demyelinating CNS disease and has distinct clinical and radiological features. Neuromyelitis optica spectrum disorder (NMOSD) is an antibody related auto-immune disease known for invalidating episodes of myelitis and optic neuritis. Objective Reporting the case of a 29-year old woman with a disease course typical for relapsing remitting MS with consistent radiological and spinal fluid findings, who developed longitudinally extensive transverse myelitis (LETM) with positive aquaporin 4 antibodies, fulfilling the diagnostic criteria for NMOSD. Methods Case report. Results LETM is not consistent with MS. Consider NMOSD even in patients with typical MS and check for aquaporin-4 antibodies, with important treatment consequences.",
keywords = "Aquaporin 4 antibodies, Longitudinally extensive transverse myelitis, Multiple sclerosis, Neuromyelitis optica spectrum disorder, Rituximab",
author = "{van Rooij}, {Lucas C.} and Wattjes, {Mike P.} and {de Jong}, {Brigit A.} and {van Oosten}, {Bob W.}",
year = "2017",
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doi = "10.1016/j.msard.2017.06.009",
language = "English",
volume = "17",
pages = "54--56",
journal = "Multiple Sclerosis and Related Disorders",
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publisher = "Elsevier",

}

Neuromyelitis optica spectrum disorder mimicking multiple sclerosis. / van Rooij, Lucas C.; Wattjes, Mike P.; de Jong, Brigit A.; van Oosten, Bob W.

In: Multiple Sclerosis and Related Disorders, Vol. 17, 01.10.2017, p. 54-56.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Neuromyelitis optica spectrum disorder mimicking multiple sclerosis

AU - van Rooij, Lucas C.

AU - Wattjes, Mike P.

AU - de Jong, Brigit A.

AU - van Oosten, Bob W.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background MS is a demyelinating CNS disease and has distinct clinical and radiological features. Neuromyelitis optica spectrum disorder (NMOSD) is an antibody related auto-immune disease known for invalidating episodes of myelitis and optic neuritis. Objective Reporting the case of a 29-year old woman with a disease course typical for relapsing remitting MS with consistent radiological and spinal fluid findings, who developed longitudinally extensive transverse myelitis (LETM) with positive aquaporin 4 antibodies, fulfilling the diagnostic criteria for NMOSD. Methods Case report. Results LETM is not consistent with MS. Consider NMOSD even in patients with typical MS and check for aquaporin-4 antibodies, with important treatment consequences.

AB - Background MS is a demyelinating CNS disease and has distinct clinical and radiological features. Neuromyelitis optica spectrum disorder (NMOSD) is an antibody related auto-immune disease known for invalidating episodes of myelitis and optic neuritis. Objective Reporting the case of a 29-year old woman with a disease course typical for relapsing remitting MS with consistent radiological and spinal fluid findings, who developed longitudinally extensive transverse myelitis (LETM) with positive aquaporin 4 antibodies, fulfilling the diagnostic criteria for NMOSD. Methods Case report. Results LETM is not consistent with MS. Consider NMOSD even in patients with typical MS and check for aquaporin-4 antibodies, with important treatment consequences.

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KW - Longitudinally extensive transverse myelitis

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KW - Neuromyelitis optica spectrum disorder

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