Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models

Aishwarya G. Nadadhur, Mouhamed Alsaqati, Lisa Gasparotto, Paulien Cornelissen-Steijger, Eline van Hugte, Stephanie Dooves, Adrian J. Harwood, Vivi M. Heine

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Nadadhur et al. generated TSC disease models using patient iPSCs. While neuron mono-cultures showed an increase in network activity and dendritic branching, only when co-cultured with oligodendrocytes (OLs), hypertrophy and axonal abnormalities were observed. Neuron-OL interactions, modulated by mTOR regulators, support use of mixed cultures for TSC disease modeling and drug development.
Original languageEnglish
Pages (from-to)42-56
JournalStem Cell Reports
Volume12
Issue number1
DOIs
Publication statusPublished - 2019

Cite this

G. Nadadhur, Aishwarya ; Alsaqati, Mouhamed ; Gasparotto, Lisa ; Cornelissen-Steijger, Paulien ; van Hugte, Eline ; Dooves, Stephanie ; Harwood, Adrian J. ; Heine, Vivi M. / Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models. In: Stem Cell Reports. 2019 ; Vol. 12, No. 1. pp. 42-56.
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abstract = "Nadadhur et al. generated TSC disease models using patient iPSCs. While neuron mono-cultures showed an increase in network activity and dendritic branching, only when co-cultured with oligodendrocytes (OLs), hypertrophy and axonal abnormalities were observed. Neuron-OL interactions, modulated by mTOR regulators, support use of mixed cultures for TSC disease modeling and drug development.",
author = "{G. Nadadhur}, Aishwarya and Mouhamed Alsaqati and Lisa Gasparotto and Paulien Cornelissen-Steijger and {van Hugte}, Eline and Stephanie Dooves and Harwood, {Adrian J.} and Heine, {Vivi M.}",
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G. Nadadhur, A, Alsaqati, M, Gasparotto, L, Cornelissen-Steijger, P, van Hugte, E, Dooves, S, Harwood, AJ & Heine, VM 2019, 'Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models' Stem Cell Reports, vol. 12, no. 1, pp. 42-56. https://doi.org/10.1016/j.stemcr.2018.11.019

Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models. / G. Nadadhur, Aishwarya; Alsaqati, Mouhamed; Gasparotto, Lisa; Cornelissen-Steijger, Paulien; van Hugte, Eline; Dooves, Stephanie; Harwood, Adrian J.; Heine, Vivi M.

In: Stem Cell Reports, Vol. 12, No. 1, 2019, p. 42-56.

Research output: Contribution to journalArticleAcademicpeer-review

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