TY - JOUR
T1 - Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models
AU - G. Nadadhur, Aishwarya
AU - Alsaqati, Mouhamed
AU - Gasparotto, Lisa
AU - Cornelissen-Steijger, Paulien
AU - van Hugte, Eline
AU - Dooves, Stephanie
AU - Harwood, Adrian J.
AU - Heine, Vivi M.
PY - 2019/1/8
Y1 - 2019/1/8
N2 - Nadadhur et al. generated TSC disease models using patient iPSCs. While neuron mono-cultures showed an increase in network activity and dendritic branching, only when co-cultured with oligodendrocytes (OLs), hypertrophy and axonal abnormalities were observed. Neuron-OL interactions, modulated by mTOR regulators, support use of mixed cultures for TSC disease modeling and drug development.
AB - Nadadhur et al. generated TSC disease models using patient iPSCs. While neuron mono-cultures showed an increase in network activity and dendritic branching, only when co-cultured with oligodendrocytes (OLs), hypertrophy and axonal abnormalities were observed. Neuron-OL interactions, modulated by mTOR regulators, support use of mixed cultures for TSC disease modeling and drug development.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059554537&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30581017
U2 - 10.1016/j.stemcr.2018.11.019
DO - 10.1016/j.stemcr.2018.11.019
M3 - Article
C2 - 30581017
VL - 12
SP - 42
EP - 56
JO - Stem Cell Reports
JF - Stem Cell Reports
SN - 2213-6711
IS - 1
ER -