New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelos Evangelou, Alcohol Genome-Wide Consortium, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, Ibrahim Karaman, Joshua Elliott, Qiang Luo, Stefanie Aeschbacher, Traci M. Bartz, Sebastian E. Baumeister, Peter S. Braund, Michael R. Brown, Jennifer A. Brody & 44 others Toni Kim Clarke, Niki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A. Kentistou, Peter K. Joshi, Rozenn N. Lemaitre, Penelope A. Lind, Leo Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Christopher P. Nelson, Ilja M. Nolte, Mia Maria Perälä, Ozren Polasek, David Porteous, Scott M. Ratliff, Jennifer A. Smith, Alena Stančáková, Alexander Teumer, Samuli Tuominen, Sébastien Thériault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E. Arking, Juha Auvinen, Pim van der Harst, Catharina A. Hartman, Mika Kähönen, Sharon L. R. Kardia, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas Gilson, BWJH Penninx

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Original languageEnglish
Pages (from-to)950-961
Number of pages12
JournalNature Human Behaviour
Volume3
Issue number9
DOIs
Publication statusPublished - 1 Sep 2019

Cite this

Evangelou, E., Alcohol Genome-Wide Consortium, Gao, H., Chu, C., Ntritsos, G., Blakeley, P., ... Penninx, BWJH. (2019). New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature Human Behaviour, 3(9), 950-961. https://doi.org/10.1038/s41562-019-0653-z
Evangelou, Evangelos ; Alcohol Genome-Wide Consortium ; Gao, He ; Chu, Congying ; Ntritsos, Georgios ; Blakeley, Paul ; Butts, Andrew R. ; Pazoki, Raha ; Suzuki, Hideaki ; Koskeridis, Fotios ; Yiorkas, Andrianos M. ; Karaman, Ibrahim ; Elliott, Joshua ; Luo, Qiang ; Aeschbacher, Stefanie ; Bartz, Traci M. ; Baumeister, Sebastian E. ; Braund, Peter S. ; Brown, Michael R. ; Brody, Jennifer A. ; Clarke, Toni Kim ; Dimou, Niki ; Faul, Jessica D. ; Homuth, Georg ; Jackson, Anne U. ; Kentistou, Katherine A. ; Joshi, Peter K. ; Lemaitre, Rozenn N. ; Lind, Penelope A. ; Lyytikäinen, Leo Pekka ; Mangino, Massimo ; Milaneschi, Yuri ; Nelson, Christopher P. ; Nolte, Ilja M. ; Perälä, Mia Maria ; Polasek, Ozren ; Porteous, David ; Ratliff, Scott M. ; Smith, Jennifer A. ; Stančáková, Alena ; Teumer, Alexander ; Tuominen, Samuli ; Thériault, Sébastien ; Vangipurapu, Jagadish ; Whitfield, John B. ; Wood, Alexis ; Yao, Jie ; Yu, Bing ; Zhao, Wei ; Arking, Dan E. ; Auvinen, Juha ; van der Harst, Pim ; Hartman, Catharina A. ; Kähönen, Mika ; Kardia, Sharon L. R. ; Kuusisto, Johanna ; Laakso, Markku ; Lahti, Jari ; Lehtimäki, Terho ; McIntosh, Andrew M. ; Mohlke, Karen L. ; Morrison, Alanna C. ; Gilson, Nicholas ; Penninx, BWJH. / New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. In: Nature Human Behaviour. 2019 ; Vol. 3, No. 9. pp. 950-961.
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Evangelou, E, Alcohol Genome-Wide Consortium, Gao, H, Chu, C, Ntritsos, G, Blakeley, P, Butts, AR, Pazoki, R, Suzuki, H, Koskeridis, F, Yiorkas, AM, Karaman, I, Elliott, J, Luo, Q, Aeschbacher, S, Bartz, TM, Baumeister, SE, Braund, PS, Brown, MR, Brody, JA, Clarke, TK, Dimou, N, Faul, JD, Homuth, G, Jackson, AU, Kentistou, KA, Joshi, PK, Lemaitre, RN, Lind, PA, Lyytikäinen, LP, Mangino, M, Milaneschi, Y, Nelson, CP, Nolte, IM, Perälä, MM, Polasek, O, Porteous, D, Ratliff, SM, Smith, JA, Stančáková, A, Teumer, A, Tuominen, S, Thériault, S, Vangipurapu, J, Whitfield, JB, Wood, A, Yao, J, Yu, B, Zhao, W, Arking, DE, Auvinen, J, van der Harst, P, Hartman, CA, Kähönen, M, Kardia, SLR, Kuusisto, J, Laakso, M, Lahti, J, Lehtimäki, T, McIntosh, AM, Mohlke, KL, Morrison, AC, Gilson, N & Penninx, BWJH 2019, 'New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders' Nature Human Behaviour, vol. 3, no. 9, pp. 950-961. https://doi.org/10.1038/s41562-019-0653-z

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. / Evangelou, Evangelos; Alcohol Genome-Wide Consortium; Gao, He; Chu, Congying; Ntritsos, Georgios; Blakeley, Paul; Butts, Andrew R.; Pazoki, Raha; Suzuki, Hideaki; Koskeridis, Fotios; Yiorkas, Andrianos M.; Karaman, Ibrahim; Elliott, Joshua; Luo, Qiang; Aeschbacher, Stefanie; Bartz, Traci M.; Baumeister, Sebastian E.; Braund, Peter S.; Brown, Michael R.; Brody, Jennifer A.; Clarke, Toni Kim; Dimou, Niki; Faul, Jessica D.; Homuth, Georg; Jackson, Anne U.; Kentistou, Katherine A.; Joshi, Peter K.; Lemaitre, Rozenn N.; Lind, Penelope A.; Lyytikäinen, Leo Pekka; Mangino, Massimo; Milaneschi, Yuri; Nelson, Christopher P.; Nolte, Ilja M.; Perälä, Mia Maria; Polasek, Ozren; Porteous, David; Ratliff, Scott M.; Smith, Jennifer A.; Stančáková, Alena; Teumer, Alexander; Tuominen, Samuli; Thériault, Sébastien; Vangipurapu, Jagadish; Whitfield, John B.; Wood, Alexis; Yao, Jie; Yu, Bing; Zhao, Wei; Arking, Dan E.; Auvinen, Juha; van der Harst, Pim; Hartman, Catharina A.; Kähönen, Mika; Kardia, Sharon L. R.; Kuusisto, Johanna; Laakso, Markku; Lahti, Jari; Lehtimäki, Terho; McIntosh, Andrew M.; Mohlke, Karen L.; Morrison, Alanna C.; Gilson, Nicholas; Penninx, BWJH.

In: Nature Human Behaviour, Vol. 3, No. 9, 01.09.2019, p. 950-961.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

AU - Evangelou, Evangelos

AU - Alcohol Genome-Wide Consortium

AU - Gao, He

AU - Chu, Congying

AU - Ntritsos, Georgios

AU - Blakeley, Paul

AU - Butts, Andrew R.

AU - Pazoki, Raha

AU - Suzuki, Hideaki

AU - Koskeridis, Fotios

AU - Yiorkas, Andrianos M.

AU - Karaman, Ibrahim

AU - Elliott, Joshua

AU - Luo, Qiang

AU - Aeschbacher, Stefanie

AU - Bartz, Traci M.

AU - Baumeister, Sebastian E.

AU - Braund, Peter S.

AU - Brown, Michael R.

AU - Brody, Jennifer A.

AU - Clarke, Toni Kim

AU - Dimou, Niki

AU - Faul, Jessica D.

AU - Homuth, Georg

AU - Jackson, Anne U.

AU - Kentistou, Katherine A.

AU - Joshi, Peter K.

AU - Lemaitre, Rozenn N.

AU - Lind, Penelope A.

AU - Lyytikäinen, Leo Pekka

AU - Mangino, Massimo

AU - Milaneschi, Yuri

AU - Nelson, Christopher P.

AU - Nolte, Ilja M.

AU - Perälä, Mia Maria

AU - Polasek, Ozren

AU - Porteous, David

AU - Ratliff, Scott M.

AU - Smith, Jennifer A.

AU - Stančáková, Alena

AU - Teumer, Alexander

AU - Tuominen, Samuli

AU - Thériault, Sébastien

AU - Vangipurapu, Jagadish

AU - Whitfield, John B.

AU - Wood, Alexis

AU - Yao, Jie

AU - Yu, Bing

AU - Zhao, Wei

AU - Arking, Dan E.

AU - Auvinen, Juha

AU - van der Harst, Pim

AU - Hartman, Catharina A.

AU - Kähönen, Mika

AU - Kardia, Sharon L. R.

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Lahti, Jari

AU - Lehtimäki, Terho

AU - McIntosh, Andrew M.

AU - Mohlke, Karen L.

AU - Morrison, Alanna C.

AU - Gilson, Nicholas

AU - Penninx, BWJH

PY - 2019/9/1

Y1 - 2019/9/1

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Evangelou E, Alcohol Genome-Wide Consortium, Gao H, Chu C, Ntritsos G, Blakeley P et al. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature Human Behaviour. 2019 Sep 1;3(9):950-961. https://doi.org/10.1038/s41562-019-0653-z