TY - JOUR
T1 - New cell sources for T cell engineering and adoptive immunotherapy
AU - Themeli, Maria
AU - Rivière, Isabelle
AU - Sadelain, Michel
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015/4/2
Y1 - 2015/4/2
N2 - The promising clinical results obtained with engineered T cells, including chimeric antigen receptor (CAR) therapy, call for further advancements to facilitate and broaden their applicability. One potentially beneficial innovation is to exploit new T cell sources that reduce the need for autologous cell manufacturing and enable cell transfer across histocompatibility barriers. Here we review emerging T cell engineering approaches that utilize alternative T cell sources, which include virus-specific or T cell receptor-less allogeneic T cells, expanded lymphoid progenitors, and induced pluripotent stem cell (iPSC)-derived T lymphocytes. The latter offer the prospect for true off-the-shelf, genetically enhanced, histocompatible cell therapy products.
AB - The promising clinical results obtained with engineered T cells, including chimeric antigen receptor (CAR) therapy, call for further advancements to facilitate and broaden their applicability. One potentially beneficial innovation is to exploit new T cell sources that reduce the need for autologous cell manufacturing and enable cell transfer across histocompatibility barriers. Here we review emerging T cell engineering approaches that utilize alternative T cell sources, which include virus-specific or T cell receptor-less allogeneic T cells, expanded lymphoid progenitors, and induced pluripotent stem cell (iPSC)-derived T lymphocytes. The latter offer the prospect for true off-the-shelf, genetically enhanced, histocompatible cell therapy products.
KW - Animals
KW - Cell Engineering/methods
KW - Genetic Engineering
KW - Histocompatibility
KW - Humans
KW - Immunologic Deficiency Syndromes/immunology
KW - Immunotherapy, Adoptive
KW - Induced Pluripotent Stem Cells/immunology
KW - Lymphoid Progenitor Cells/immunology
KW - Receptors, Antigen, T-Cell/genetics
KW - Recombinant Fusion Proteins/genetics
KW - T-Lymphocytes/immunology
U2 - 10.1016/j.stem.2015.03.011
DO - 10.1016/j.stem.2015.03.011
M3 - Review article
C2 - 25842976
VL - 16
SP - 357
EP - 366
JO - Stem Cell Research
JF - Stem Cell Research
SN - 1873-5061
IS - 4
ER -