New findings from the bipolar collaborative network: Clinical implications for therapeutics

Robert M. Post*, Lori L. Altshuler, Mark A. Frye, Trisha Suppes, Susan McElroy, Paul E. Keck, Gabriele S. Leverich, Ralph Kupka, Willem A. Nolen, Heinz Grunze

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalCurrent Psychiatry Reports
Issue number6
Publication statusPublished - Dec 2006
Externally publishedYes

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