NIEUWE INZICHTEN IN DE PATHOGENESE, PLAATS VAN NIET-ANTIBIOTISCHE THERAPIE EN PREVENTIE VAN BACTERIELE MENINGITIS

Translated title of the contribution: New insights in the pathogenesis, the role of non antibiotic therapy and prevention of bacterial meningitis

A. M. Van Furth, S. P M Geelen, J. J. Roord

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

To improve the prognosis of bacterial meningitis much interest has been focussed on the therapeutic effect of antiinflammatory drugs. Several forms of additional therapy have been studied mainly in an experimental animal setting. Possible candidates for such treatment are glucocorticosteroids, pentoxifylline and nonsteroidal anti-inflammatory compounds. Natural inhibitors of cytokines and monoclonal antibodies against endotoxin, cytokines and leukocyte-adhesion molecules are also studied. The main purpose of all these compounds is to modify the inflammatory response, in particular the influx of leukocytes and plasma-exudate in the subarachnoid space. Vaccination can prevent the development of bacterial meningitis. Current vaccines available are against Haemophilus type b, pneumococci and meningococci A and C. However, no vaccine against meningococci serogroup B is developed yet.

Original languageDutch
Pages (from-to)191-194
Number of pages4
JournalTijdschrift voor Kindergeneeskunde
Volume63
Issue number5
Publication statusPublished - 1 Jan 1995

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