TY - JOUR
T1 - No evidence for decreased D2/3 receptor availability and frontal hypoperfusion in subjects with compulsive pornography use
AU - Stormezand, Gilles N.
AU - Doorduin, Janine
AU - Chaves, Lumi T.
AU - Vállez García, David
AU - Nienhuis, Fokko J.
AU - Schoevers, Robert A.
AU - Kremer, Berry P. H.
AU - Booij, Jan
AU - Dierckx, Rudi A. J. O.
N1 - Funding Information:
We thank Gert-Jan Meerkerk of the IVO Addiction Research Institute Rotterdam, The Netherlands Erasmus Medical Center Rotterdam, The Netherlands, for his cooperation and sharing of his knowledge and experience in the field.
Publisher Copyright:
© 2021 The Authors
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/30
Y1 - 2021/5/30
N2 - Pornographic addiction refers to an addiction model associated with compulsive and repeated use of pornographic material. Whether the use of pornography may indeed become addictive remains a matter of debate. The current study investigated whether compulsive pornography use (CPU) is accompanied by reduced D2/3 receptor availability in the striatum and frontal hypofunctionality. Male subjects between 18 and 50 years of age with and without CPU were recruited using online and newspaper advertisements. Questionnaires were used to the assess the severity of compulsive pornography use (CIUS) and symptoms of depression, impulsivity and sensation seeking. Dopaminergic imaging was performed using [11C]-raclopride PET. Striatal binding potentials (BPND) and regional frontal cerebral influx values (R1) of [11C]-raclopride were calculated. Arterial Spin Labeling (ASL) MRI was performed to assess regional cerebral blood flow. No group differences between striatal BPND's of [11C]-raclopride in subjects with (n = 15) and without (n = 10) CPU were detected. In CPU subjects, no correlation was found between the CIUS score and striatal BPND's. Cerebral R1 values in frontal brain regions and cerebral blood flow measurements did not differ between groups. The current study fails to provide imaging support for sharing similar neurobiological alterations as previously has been reported in other addictive modalities.
AB - Pornographic addiction refers to an addiction model associated with compulsive and repeated use of pornographic material. Whether the use of pornography may indeed become addictive remains a matter of debate. The current study investigated whether compulsive pornography use (CPU) is accompanied by reduced D2/3 receptor availability in the striatum and frontal hypofunctionality. Male subjects between 18 and 50 years of age with and without CPU were recruited using online and newspaper advertisements. Questionnaires were used to the assess the severity of compulsive pornography use (CIUS) and symptoms of depression, impulsivity and sensation seeking. Dopaminergic imaging was performed using [11C]-raclopride PET. Striatal binding potentials (BPND) and regional frontal cerebral influx values (R1) of [11C]-raclopride were calculated. Arterial Spin Labeling (ASL) MRI was performed to assess regional cerebral blood flow. No group differences between striatal BPND's of [11C]-raclopride in subjects with (n = 15) and without (n = 10) CPU were detected. In CPU subjects, no correlation was found between the CIUS score and striatal BPND's. Cerebral R1 values in frontal brain regions and cerebral blood flow measurements did not differ between groups. The current study fails to provide imaging support for sharing similar neurobiological alterations as previously has been reported in other addictive modalities.
KW - Cerebral blood flow
KW - Dopaminergic imaging
KW - Pornographic addiction
UR - http://www.scopus.com/inward/record.url?scp=85103099902&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2021.111284
DO - 10.1016/j.pscychresns.2021.111284
M3 - Article
C2 - 33774451
VL - 311
JO - Psychiatry Research: Neuroimaging
JF - Psychiatry Research: Neuroimaging
SN - 0925-4927
M1 - 111284
ER -