No evidence of microbleeds in ALS patients at 7 Tesla MRI

Esther Verstraete*, Geert Jan Biessels, Martijn P. Van Den Heuvel, Fredy Visser, Peter R. Luijten, Leonard H. Van Den Berg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.

Original languageEnglish
Pages (from-to)555-557
Number of pages3
JournalAmyotrophic Lateral Sclerosis
Volume11
Issue number6
DOIs
Publication statusPublished - 1 Dec 2010

Cite this

Verstraete, E., Biessels, G. J., Van Den Heuvel, M. P., Visser, F., Luijten, P. R., & Van Den Berg, L. H. (2010). No evidence of microbleeds in ALS patients at 7 Tesla MRI. Amyotrophic Lateral Sclerosis, 11(6), 555-557. https://doi.org/10.3109/17482968.2010.513053