TY - JOUR
T1 - Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
AU - Bär, Christian
AU - Chatterjee, Shambhabi
AU - Falcão Pires, Inês
AU - Rodrigues, Patrícia
AU - Sluijter, Joost P. G.
AU - Boon, Reinier A.
AU - Nevado, Rosa M.
AU - Andrés, Vicente
AU - Sansonetti, Marida
AU - de Windt, Leon
AU - Ciccarelli, Michele
AU - Hamdani, Nazha
AU - Heymans, Stephane
AU - Figuinha Videira, Raquel
AU - Tocchetti, Carlo G.
AU - Giacca, Mauro
AU - Zacchigna, Serena
AU - Engelhardt, Stefan
AU - Dimmeler, Stefanie
AU - Madonna, Rosalinda
AU - Thum, Thomas
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.
AB - Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.
KW - Aging
KW - Cardiovascular disease
KW - MicroRNA
KW - Non-coding RNA
KW - Noncoding RNA therapy
KW - Regeneration
KW - Remodelling
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090079575&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/32638021
UR - http://www.scopus.com/inward/record.url?scp=85090079575&partnerID=8YFLogxK
U2 - 10.1093/cvr/cvaa195
DO - 10.1093/cvr/cvaa195
M3 - Review article
C2 - 32638021
VL - 116
SP - 1805
EP - 1819
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 11
ER -