Non-human primate models of experimental autoimmune encephalomyelitis: Variations on a theme

Bert A 't Hart, Jan Bauer, Herbert P M Brok, Sandra Amor

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Despite years of intensive research into multiple sclerosis (MS) scientists have not yet succeeded in developing an absolute therapy for the treatment of this disabling disease of the human central nervous system. The wide immunological gap between inbred rodent strains and the heterogeneous human population is probably the single most important factor that hampers the translation of scientific principles developed in rodents into effective therapies for MS. Because of the closer immunological proximity to humans, non-human primates provide useful experimental models that may help to bridge this gap. Here we review the models of experimental autoimmune encephalomyelitis in rhesus macaques and common marmosets. We will discuss the salient points of the models and suggest how these may represent the spectrum of inflammatory demyelinating diseases of the central nervous system in humans.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalJournal of Neuroimmunology
Volume168
Issue number1-2
DOIs
Publication statusPublished - Nov 2005

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