Non-invasively measured structural and functional arterial characteristics and coronary heart disease risk in middle aged and elderly men

Marijke J.C.A. van Trijp, Willem J.W. Bos, Yvonne T. van der Schouw, Majon Muller, Diederick E. Grobbee, Michiel L. Bots

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: In cardiovascular (CV) epidemiology, interest increases in studying etiologic and prognostic implications of early structural or functional changes of the large arteries. Examples of such measurements are pulse wave velocity (PWV), carotid intima-media thickness (CIMT) and augmentation index (AIx). PWV and CIMT are established markers of CV risk whereas the role of AIx as indicator of risk has not fully been established. Therefore, our aim was to relate AIx to CV risk and to compare the magnitude of relations of PWV, CIMT and AIx to CV risk. Methods: Two hundred and ninty-nine men free from cardiovascular disease (mean age 59.2 years), participated in this cross-sectional study. Cardiovascular risk profile was determined and 10-year coronary heart disease risk was estimated using the Framingham risk score (FRS). PWV, CIMT and AIx were measured and data were analyzed using linear regression models. Results: PWV and CIMT were strongest related to FRS whereas AIx showed the weakest relation. Ten-year coronary heart disease risk increased 6.24%, 95% confidence interval (CI) [5.11;7.37] per standard deviation (S.D.) increase in PWV, 6.39% [5.24;7.54] per S.D. increase in CIMT and 2.50% [1.19;3.80] per S.D. increase in AIx. Conclusion: In middle aged and elderly men AIx is related to CV risk. However, compared with AIx, PWV and CIMT seem better markers of cardiovascular risk.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalAtherosclerosis
Volume187
Issue number1
DOIs
Publication statusPublished - 1 Jul 2006

Cite this

van Trijp, Marijke J.C.A. ; Bos, Willem J.W. ; van der Schouw, Yvonne T. ; Muller, Majon ; Grobbee, Diederick E. ; Bots, Michiel L. / Non-invasively measured structural and functional arterial characteristics and coronary heart disease risk in middle aged and elderly men. In: Atherosclerosis. 2006 ; Vol. 187, No. 1. pp. 110-115.
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title = "Non-invasively measured structural and functional arterial characteristics and coronary heart disease risk in middle aged and elderly men",
abstract = "Background: In cardiovascular (CV) epidemiology, interest increases in studying etiologic and prognostic implications of early structural or functional changes of the large arteries. Examples of such measurements are pulse wave velocity (PWV), carotid intima-media thickness (CIMT) and augmentation index (AIx). PWV and CIMT are established markers of CV risk whereas the role of AIx as indicator of risk has not fully been established. Therefore, our aim was to relate AIx to CV risk and to compare the magnitude of relations of PWV, CIMT and AIx to CV risk. Methods: Two hundred and ninty-nine men free from cardiovascular disease (mean age 59.2 years), participated in this cross-sectional study. Cardiovascular risk profile was determined and 10-year coronary heart disease risk was estimated using the Framingham risk score (FRS). PWV, CIMT and AIx were measured and data were analyzed using linear regression models. Results: PWV and CIMT were strongest related to FRS whereas AIx showed the weakest relation. Ten-year coronary heart disease risk increased 6.24{\%}, 95{\%} confidence interval (CI) [5.11;7.37] per standard deviation (S.D.) increase in PWV, 6.39{\%} [5.24;7.54] per S.D. increase in CIMT and 2.50{\%} [1.19;3.80] per S.D. increase in AIx. Conclusion: In middle aged and elderly men AIx is related to CV risk. However, compared with AIx, PWV and CIMT seem better markers of cardiovascular risk.",
keywords = "Arterial wave reflections, Cardiovascular disease, Carotid intima-media thickness, Framingham risk score, Pulse wave velocity",
author = "{van Trijp}, {Marijke J.C.A.} and Bos, {Willem J.W.} and {van der Schouw}, {Yvonne T.} and Majon Muller and Grobbee, {Diederick E.} and Bots, {Michiel L.}",
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Non-invasively measured structural and functional arterial characteristics and coronary heart disease risk in middle aged and elderly men. / van Trijp, Marijke J.C.A.; Bos, Willem J.W.; van der Schouw, Yvonne T.; Muller, Majon; Grobbee, Diederick E.; Bots, Michiel L.

In: Atherosclerosis, Vol. 187, No. 1, 01.07.2006, p. 110-115.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Non-invasively measured structural and functional arterial characteristics and coronary heart disease risk in middle aged and elderly men

AU - van Trijp, Marijke J.C.A.

AU - Bos, Willem J.W.

AU - van der Schouw, Yvonne T.

AU - Muller, Majon

AU - Grobbee, Diederick E.

AU - Bots, Michiel L.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Background: In cardiovascular (CV) epidemiology, interest increases in studying etiologic and prognostic implications of early structural or functional changes of the large arteries. Examples of such measurements are pulse wave velocity (PWV), carotid intima-media thickness (CIMT) and augmentation index (AIx). PWV and CIMT are established markers of CV risk whereas the role of AIx as indicator of risk has not fully been established. Therefore, our aim was to relate AIx to CV risk and to compare the magnitude of relations of PWV, CIMT and AIx to CV risk. Methods: Two hundred and ninty-nine men free from cardiovascular disease (mean age 59.2 years), participated in this cross-sectional study. Cardiovascular risk profile was determined and 10-year coronary heart disease risk was estimated using the Framingham risk score (FRS). PWV, CIMT and AIx were measured and data were analyzed using linear regression models. Results: PWV and CIMT were strongest related to FRS whereas AIx showed the weakest relation. Ten-year coronary heart disease risk increased 6.24%, 95% confidence interval (CI) [5.11;7.37] per standard deviation (S.D.) increase in PWV, 6.39% [5.24;7.54] per S.D. increase in CIMT and 2.50% [1.19;3.80] per S.D. increase in AIx. Conclusion: In middle aged and elderly men AIx is related to CV risk. However, compared with AIx, PWV and CIMT seem better markers of cardiovascular risk.

AB - Background: In cardiovascular (CV) epidemiology, interest increases in studying etiologic and prognostic implications of early structural or functional changes of the large arteries. Examples of such measurements are pulse wave velocity (PWV), carotid intima-media thickness (CIMT) and augmentation index (AIx). PWV and CIMT are established markers of CV risk whereas the role of AIx as indicator of risk has not fully been established. Therefore, our aim was to relate AIx to CV risk and to compare the magnitude of relations of PWV, CIMT and AIx to CV risk. Methods: Two hundred and ninty-nine men free from cardiovascular disease (mean age 59.2 years), participated in this cross-sectional study. Cardiovascular risk profile was determined and 10-year coronary heart disease risk was estimated using the Framingham risk score (FRS). PWV, CIMT and AIx were measured and data were analyzed using linear regression models. Results: PWV and CIMT were strongest related to FRS whereas AIx showed the weakest relation. Ten-year coronary heart disease risk increased 6.24%, 95% confidence interval (CI) [5.11;7.37] per standard deviation (S.D.) increase in PWV, 6.39% [5.24;7.54] per S.D. increase in CIMT and 2.50% [1.19;3.80] per S.D. increase in AIx. Conclusion: In middle aged and elderly men AIx is related to CV risk. However, compared with AIx, PWV and CIMT seem better markers of cardiovascular risk.

KW - Arterial wave reflections

KW - Cardiovascular disease

KW - Carotid intima-media thickness

KW - Framingham risk score

KW - Pulse wave velocity

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