TY - JOUR
T1 - Nonsmall cell lung carcinoma
T2 - Diagnostic difficulties in small biopsies and cytological specimens
AU - Bubendorf, Lukas
AU - Lantuejoul, Sylvie
AU - de Langen, Adrianus J.
AU - Thunnissen, Erik
PY - 2017/6/30
Y1 - 2017/6/30
N2 - The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. In NSCLCs negative for these biomarkers, programmed death ligand-1 immunohistochemistry is performed. Small samples (biopsy and cytology) require “tissue” management, which is best achieved by the interaction of all physicians involved.
AB - The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. In NSCLCs negative for these biomarkers, programmed death ligand-1 immunohistochemistry is performed. Small samples (biopsy and cytology) require “tissue” management, which is best achieved by the interaction of all physicians involved.
UR - http://www.scopus.com/inward/record.url?scp=85021627705&partnerID=8YFLogxK
U2 - 10.1183/16000617.0007-2017
DO - 10.1183/16000617.0007-2017
M3 - Article
C2 - 28659503
AN - SCOPUS:85021627705
VL - 26
JO - European Respiratory Review
JF - European Respiratory Review
SN - 0905-9180
IS - 144
M1 - 170007
ER -