Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls

Laura E Jonkman, Yvon Galis-de Graaf, Marjolein Bulk, Eliane Kaaij, Petra J W Pouwels, Frederik Barkhof, Annemieke J M Rozemuller, Louise van der Weerd, Jeroen J G Geurts, Wilma D J van de Berg

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.

Original languageEnglish
Article number101698
JournalNeuroImage: Clinical
Volume22
Early online date29 Jan 2019
DOIs
Publication statusPublished - 2019

Cite this

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title = "Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls",
abstract = "Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.",
keywords = "Brain banking, MRI, Neuropathology, Non-neurological controls",
author = "Jonkman, {Laura E} and Graaf, {Yvon Galis-de} and Marjolein Bulk and Eliane Kaaij and Pouwels, {Petra J W} and Frederik Barkhof and Rozemuller, {Annemieke J M} and {van der Weerd}, Louise and Geurts, {Jeroen J G} and {van de Berg}, {Wilma D J}",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
doi = "10.1016/j.nicl.2019.101698",
language = "English",
volume = "22",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",

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T1 - Normal Aging Brain Collection Amsterdam (NABCA)

T2 - A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls

AU - Jonkman, Laura E

AU - Graaf, Yvon Galis-de

AU - Bulk, Marjolein

AU - Kaaij, Eliane

AU - Pouwels, Petra J W

AU - Barkhof, Frederik

AU - Rozemuller, Annemieke J M

AU - van der Weerd, Louise

AU - Geurts, Jeroen J G

AU - van de Berg, Wilma D J

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.

AB - Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.

KW - Brain banking

KW - MRI

KW - Neuropathology

KW - Non-neurological controls

UR - http://www.mendeley.com/research/normal-aging-brain-collection-amsterdam-nabca-comprehensive-collection-postmortem-highfield-imaging

U2 - 10.1016/j.nicl.2019.101698

DO - 10.1016/j.nicl.2019.101698

M3 - Article

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JO - NeuroImage: Clinical

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SN - 2213-1582

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