Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries

Forouzan Yousefi; Fahimeh Lavi Arab; Karim Nikkhah; Houshang Amiri; Mahmoud Mahmoudi

doi:10.1016/j.lfs.2019.01.052

Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries

Forouzan Yousefi, Fahimeh Lavi Arab, Karim Nikkhah, Houshang Amiri, Mahmoud Mahmoudi

VU University medical center

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Peripheral nerve injury (PNI) is a common life-changing disability of peripheral nervous system with significant socioeconomic consequences. Conventional therapeutic approaches for PNI have several drawbacks such as need to autologous nerve scarifying, surplus surgery, and difficult accessibility to donor nerve; therefore, other therapeutic strategies such as mesenchymal stem cells (MSCs) therapy are getting more interesting. MSCs have been proved to be safe and efficient in numerous degenerative diseases of central and peripheral nervous systems. In this paper, we review novel biotechnological advancements in treating PNI using MSCs.

Original language	English
Pages (from-to)	99-108
Journal	Life Sciences
Volume	221
DOIs	https://doi.org/10.1016/j.lfs.2019.01.052
Publication status	Published - 2019

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10.1016/j.lfs.2019.01.052

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Yousefi, F., Lavi Arab, F., Nikkhah, K., Amiri, H., & Mahmoudi, M. (2019). Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries. Life Sciences, 221, 99-108. https://doi.org/10.1016/j.lfs.2019.01.052

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title = "Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries",

abstract = "Peripheral nerve injury (PNI) is a common life-changing disability of peripheral nervous system with significant socioeconomic consequences. Conventional therapeutic approaches for PNI have several drawbacks such as need to autologous nerve scarifying, surplus surgery, and difficult accessibility to donor nerve; therefore, other therapeutic strategies such as mesenchymal stem cells (MSCs) therapy are getting more interesting. MSCs have been proved to be safe and efficient in numerous degenerative diseases of central and peripheral nervous systems. In this paper, we review novel biotechnological advancements in treating PNI using MSCs.",

keywords = "Mesenchymal stem cells, Peripheral nerve injuries",

author = "Forouzan Yousefi and {Lavi Arab}, Fahimeh and Karim Nikkhah and Houshang Amiri and Mahmoud Mahmoudi",

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language = "English",

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AU - Nikkhah, Karim

AU - Amiri, Houshang

AU - Mahmoudi, Mahmoud

PY - 2019

Y1 - 2019

N2 - Peripheral nerve injury (PNI) is a common life-changing disability of peripheral nervous system with significant socioeconomic consequences. Conventional therapeutic approaches for PNI have several drawbacks such as need to autologous nerve scarifying, surplus surgery, and difficult accessibility to donor nerve; therefore, other therapeutic strategies such as mesenchymal stem cells (MSCs) therapy are getting more interesting. MSCs have been proved to be safe and efficient in numerous degenerative diseases of central and peripheral nervous systems. In this paper, we review novel biotechnological advancements in treating PNI using MSCs.

AB - Peripheral nerve injury (PNI) is a common life-changing disability of peripheral nervous system with significant socioeconomic consequences. Conventional therapeutic approaches for PNI have several drawbacks such as need to autologous nerve scarifying, surplus surgery, and difficult accessibility to donor nerve; therefore, other therapeutic strategies such as mesenchymal stem cells (MSCs) therapy are getting more interesting. MSCs have been proved to be safe and efficient in numerous degenerative diseases of central and peripheral nervous systems. In this paper, we review novel biotechnological advancements in treating PNI using MSCs.

KW - Mesenchymal stem cells

KW - Peripheral nerve injuries

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