Novel Perceived Stress and Life Events Precede Flares of Inflammatory Bowel Disease: A Prospective 12-Month Follow-Up Study

Dion S. J. Wintjens, Marin J. de Jong, Andrea E. van der Meulen-de Jong, Mariëlle J. Romberg-Camps, Marco C. Becx, Jeroen P. Maljaars, Ad A. van Bodegraven, Nofel Mahmmod, Tineke Markus, Jeoffrey Haans, Ad A. M. Masclee, Bjorn Winkens, Daisy M. A. E. Jonkers, Marie J. Pierik

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Background and Aims Inflammatory bowel disease [IBD] is characterized by recurrent disease flares. The impact of psychosocial wellbeing on the occurrence of flares is unclear. In this prospective study, we aimed to evaluate the association between patient-reported psychosocial wellbeing and disease flares using continuous monitoring. Methods Consecutive IBD patients were recruited from the myIBDcoach telemedicine study cohort. Over 12 months, participants reported on disease activity together with anxiety, depression, fatigue, perceived stress and life events every 1-3 months. Flares were defined using a combination of clinical disease activity and additional measurements. Generalized estimating equation models were used to assess associations between psychosocial wellbeing and flares over time. The influences of both the presence of psychosocial symptoms in general as well as novel psychosocial symptoms were analysed. Results In total, 417 patients were included. Forty-nine patients [11.8%] experienced a flare during the study period. The occurrence of life events in the preceding 3 months was positively associated with flares (odds ratio [OR] = 1.81; 95% confidence interval [CI] = 1.04-3.17), while the presence of anxiety, depression, fatigue and perceived stress in general was not. However, novel perceived stress [OR = 2.92; 95% CI = 1.44-5.90] was associated with flares. Conclusions The occurrence of life events and novel perceived stress are associated with disease flares in the next 3 months, while the presence of perceived stress in general is not. These findings underline the importance of continuous personalized monitoring of IBD patients and may contribute to the prevention of disease flares.
Original languageEnglish
Pages (from-to)410-416
JournalJournal of Crohn's and Colitis
Volume13
Issue number4
DOIs
Publication statusPublished - 2019

Cite this

Wintjens, D. S. J., de Jong, M. J., van der Meulen-de Jong, A. E., Romberg-Camps, M. J., Becx, M. C., Maljaars, J. P., ... Pierik, M. J. (2019). Novel Perceived Stress and Life Events Precede Flares of Inflammatory Bowel Disease: A Prospective 12-Month Follow-Up Study. Journal of Crohn's and Colitis, 13(4), 410-416. https://doi.org/10.1093/ecco-jcc/jjy177
Wintjens, Dion S. J. ; de Jong, Marin J. ; van der Meulen-de Jong, Andrea E. ; Romberg-Camps, Mariëlle J. ; Becx, Marco C. ; Maljaars, Jeroen P. ; van Bodegraven, Ad A. ; Mahmmod, Nofel ; Markus, Tineke ; Haans, Jeoffrey ; Masclee, Ad A. M. ; Winkens, Bjorn ; Jonkers, Daisy M. A. E. ; Pierik, Marie J. / Novel Perceived Stress and Life Events Precede Flares of Inflammatory Bowel Disease: A Prospective 12-Month Follow-Up Study. In: Journal of Crohn's and Colitis. 2019 ; Vol. 13, No. 4. pp. 410-416.
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title = "Novel Perceived Stress and Life Events Precede Flares of Inflammatory Bowel Disease: A Prospective 12-Month Follow-Up Study",
abstract = "Background and Aims Inflammatory bowel disease [IBD] is characterized by recurrent disease flares. The impact of psychosocial wellbeing on the occurrence of flares is unclear. In this prospective study, we aimed to evaluate the association between patient-reported psychosocial wellbeing and disease flares using continuous monitoring. Methods Consecutive IBD patients were recruited from the myIBDcoach telemedicine study cohort. Over 12 months, participants reported on disease activity together with anxiety, depression, fatigue, perceived stress and life events every 1-3 months. Flares were defined using a combination of clinical disease activity and additional measurements. Generalized estimating equation models were used to assess associations between psychosocial wellbeing and flares over time. The influences of both the presence of psychosocial symptoms in general as well as novel psychosocial symptoms were analysed. Results In total, 417 patients were included. Forty-nine patients [11.8{\%}] experienced a flare during the study period. The occurrence of life events in the preceding 3 months was positively associated with flares (odds ratio [OR] = 1.81; 95{\%} confidence interval [CI] = 1.04-3.17), while the presence of anxiety, depression, fatigue and perceived stress in general was not. However, novel perceived stress [OR = 2.92; 95{\%} CI = 1.44-5.90] was associated with flares. Conclusions The occurrence of life events and novel perceived stress are associated with disease flares in the next 3 months, while the presence of perceived stress in general is not. These findings underline the importance of continuous personalized monitoring of IBD patients and may contribute to the prevention of disease flares.",
author = "Wintjens, {Dion S. J.} and {de Jong}, {Marin J.} and {van der Meulen-de Jong}, {Andrea E.} and Romberg-Camps, {Mari{\"e}lle J.} and Becx, {Marco C.} and Maljaars, {Jeroen P.} and {van Bodegraven}, {Ad A.} and Nofel Mahmmod and Tineke Markus and Jeoffrey Haans and Masclee, {Ad A. M.} and Bjorn Winkens and Jonkers, {Daisy M. A. E.} and Pierik, {Marie J.}",
year = "2019",
doi = "10.1093/ecco-jcc/jjy177",
language = "English",
volume = "13",
pages = "410--416",
journal = "Journal of Crohn's and Colitis",
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Wintjens, DSJ, de Jong, MJ, van der Meulen-de Jong, AE, Romberg-Camps, MJ, Becx, MC, Maljaars, JP, van Bodegraven, AA, Mahmmod, N, Markus, T, Haans, J, Masclee, AAM, Winkens, B, Jonkers, DMAE & Pierik, MJ 2019, 'Novel Perceived Stress and Life Events Precede Flares of Inflammatory Bowel Disease: A Prospective 12-Month Follow-Up Study' Journal of Crohn's and Colitis, vol. 13, no. 4, pp. 410-416. https://doi.org/10.1093/ecco-jcc/jjy177

Novel Perceived Stress and Life Events Precede Flares of Inflammatory Bowel Disease: A Prospective 12-Month Follow-Up Study. / Wintjens, Dion S. J.; de Jong, Marin J.; van der Meulen-de Jong, Andrea E.; Romberg-Camps, Mariëlle J.; Becx, Marco C.; Maljaars, Jeroen P.; van Bodegraven, Ad A.; Mahmmod, Nofel; Markus, Tineke; Haans, Jeoffrey; Masclee, Ad A. M.; Winkens, Bjorn; Jonkers, Daisy M. A. E.; Pierik, Marie J.

In: Journal of Crohn's and Colitis, Vol. 13, No. 4, 2019, p. 410-416.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Novel Perceived Stress and Life Events Precede Flares of Inflammatory Bowel Disease: A Prospective 12-Month Follow-Up Study

AU - Wintjens, Dion S. J.

AU - de Jong, Marin J.

AU - van der Meulen-de Jong, Andrea E.

AU - Romberg-Camps, Mariëlle J.

AU - Becx, Marco C.

AU - Maljaars, Jeroen P.

AU - van Bodegraven, Ad A.

AU - Mahmmod, Nofel

AU - Markus, Tineke

AU - Haans, Jeoffrey

AU - Masclee, Ad A. M.

AU - Winkens, Bjorn

AU - Jonkers, Daisy M. A. E.

AU - Pierik, Marie J.

PY - 2019

Y1 - 2019

N2 - Background and Aims Inflammatory bowel disease [IBD] is characterized by recurrent disease flares. The impact of psychosocial wellbeing on the occurrence of flares is unclear. In this prospective study, we aimed to evaluate the association between patient-reported psychosocial wellbeing and disease flares using continuous monitoring. Methods Consecutive IBD patients were recruited from the myIBDcoach telemedicine study cohort. Over 12 months, participants reported on disease activity together with anxiety, depression, fatigue, perceived stress and life events every 1-3 months. Flares were defined using a combination of clinical disease activity and additional measurements. Generalized estimating equation models were used to assess associations between psychosocial wellbeing and flares over time. The influences of both the presence of psychosocial symptoms in general as well as novel psychosocial symptoms were analysed. Results In total, 417 patients were included. Forty-nine patients [11.8%] experienced a flare during the study period. The occurrence of life events in the preceding 3 months was positively associated with flares (odds ratio [OR] = 1.81; 95% confidence interval [CI] = 1.04-3.17), while the presence of anxiety, depression, fatigue and perceived stress in general was not. However, novel perceived stress [OR = 2.92; 95% CI = 1.44-5.90] was associated with flares. Conclusions The occurrence of life events and novel perceived stress are associated with disease flares in the next 3 months, while the presence of perceived stress in general is not. These findings underline the importance of continuous personalized monitoring of IBD patients and may contribute to the prevention of disease flares.

AB - Background and Aims Inflammatory bowel disease [IBD] is characterized by recurrent disease flares. The impact of psychosocial wellbeing on the occurrence of flares is unclear. In this prospective study, we aimed to evaluate the association between patient-reported psychosocial wellbeing and disease flares using continuous monitoring. Methods Consecutive IBD patients were recruited from the myIBDcoach telemedicine study cohort. Over 12 months, participants reported on disease activity together with anxiety, depression, fatigue, perceived stress and life events every 1-3 months. Flares were defined using a combination of clinical disease activity and additional measurements. Generalized estimating equation models were used to assess associations between psychosocial wellbeing and flares over time. The influences of both the presence of psychosocial symptoms in general as well as novel psychosocial symptoms were analysed. Results In total, 417 patients were included. Forty-nine patients [11.8%] experienced a flare during the study period. The occurrence of life events in the preceding 3 months was positively associated with flares (odds ratio [OR] = 1.81; 95% confidence interval [CI] = 1.04-3.17), while the presence of anxiety, depression, fatigue and perceived stress in general was not. However, novel perceived stress [OR = 2.92; 95% CI = 1.44-5.90] was associated with flares. Conclusions The occurrence of life events and novel perceived stress are associated with disease flares in the next 3 months, while the presence of perceived stress in general is not. These findings underline the importance of continuous personalized monitoring of IBD patients and may contribute to the prevention of disease flares.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30371776

U2 - 10.1093/ecco-jcc/jjy177

DO - 10.1093/ecco-jcc/jjy177

M3 - Review article

VL - 13

SP - 410

EP - 416

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 4

ER -