NT-proBNP reflects right ventricular structure and function in pulmonary hypertension

C T Gan, G P McCann, J T Marcus, S A van Wolferen, J W Twisk, A Boonstra, P E Postmus, A Vonk-Noordegraaf

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment. The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up. There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r = -0.81). N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.

Original languageEnglish
Pages (from-to)1190-4
Number of pages5
JournalEuropean Respiratory Journal
Volume28
Issue number6
DOIs
Publication statusPublished - Dec 2006

Cite this

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title = "NT-proBNP reflects right ventricular structure and function in pulmonary hypertension",
abstract = "The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment. The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up. There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r = -0.81). N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.",
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author = "Gan, {C T} and McCann, {G P} and Marcus, {J T} and {van Wolferen}, {S A} and Twisk, {J W} and A Boonstra and Postmus, {P E} and A Vonk-Noordegraaf",
year = "2006",
month = "12",
doi = "10.1183/09031936.00016006",
language = "English",
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pages = "1190--4",
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issn = "0903-1936",
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NT-proBNP reflects right ventricular structure and function in pulmonary hypertension. / Gan, C T; McCann, G P; Marcus, J T; van Wolferen, S A; Twisk, J W; Boonstra, A; Postmus, P E; Vonk-Noordegraaf, A.

In: European Respiratory Journal, Vol. 28, No. 6, 12.2006, p. 1190-4.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - NT-proBNP reflects right ventricular structure and function in pulmonary hypertension

AU - Gan, C T

AU - McCann, G P

AU - Marcus, J T

AU - van Wolferen, S A

AU - Twisk, J W

AU - Boonstra, A

AU - Postmus, P E

AU - Vonk-Noordegraaf, A

PY - 2006/12

Y1 - 2006/12

N2 - The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment. The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up. There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r = -0.81). N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.

AB - The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment. The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up. There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r = -0.81). N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.

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KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/blood

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KW - Female

KW - Humans

KW - Hypertension, Pulmonary/metabolism

KW - Hypertrophy, Right Ventricular/metabolism

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Prognosis

KW - Protein Precursors/blood

KW - Ventricular Dysfunction, Right

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JF - European Respiratory Journal

SN - 0903-1936

IS - 6

ER -