Obstetric complications in Marfan syndrome

Lilian J. Meijboom, Willem Drenthen, Petronella G. Pieper, Maarten Groenink, Joris A.M. van der Post, Janneke Timmermans, Adriaan A. Voors, Jolien W. Roos-Hesselink, Dirk J. van Veldhuisen, Barbara J.M. Mulder*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To investigate the obstetric maternal and neonatal outcome of pregnancy in women with Marfan syndrome. Methods: Retrospective observational multi-center study based on congenital heart disease registry. Results: Sixty-three of the 122 enrolled women with Marfan syndrome had been pregnant 142 times (including 111 pregnancies > 20 weeks, 28 (20%) miscarriages and 3 elective abortions). In 40% of all completed pregnancies an obstetric and/ or neonatal complication occurred. The most important complications were an increased percentage of premature deliveries (n = 17, 15%) mainly due to preterm premature rupture of membranes and cervical incompetence and a markedly increased combined fetal and neonatal mortality of 7.1%. An obstetric and/ or neonatal complication occurred in a similar proportion of pregnancies in women with a diagnosis of Marfan syndrome before pregnancy versus women with a diagnosis of Marfan syndrome after pregnancy (39% vs. 41%, p = 0.85, respectively). Conclusion: In addition to cardiovascular complications, pregnancy in women with Marfan syndrome is associated with a high rate of premature deliveries, preterm premature rupture of membranes and increased mortality in the offspring.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalInternational Journal of Cardiology
Volume110
Issue number1
DOIs
Publication statusPublished - 7 Jun 2006

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