Obstetric complications in Marfan syndrome

Lilian J. Meijboom, Willem Drenthen, Petronella G. Pieper, Maarten Groenink, Joris A.M. van der Post, Janneke Timmermans, Adriaan A. Voors, Jolien W. Roos-Hesselink, Dirk J. van Veldhuisen, Barbara J.M. Mulder*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To investigate the obstetric maternal and neonatal outcome of pregnancy in women with Marfan syndrome. Methods: Retrospective observational multi-center study based on congenital heart disease registry. Results: Sixty-three of the 122 enrolled women with Marfan syndrome had been pregnant 142 times (including 111 pregnancies > 20 weeks, 28 (20%) miscarriages and 3 elective abortions). In 40% of all completed pregnancies an obstetric and/ or neonatal complication occurred. The most important complications were an increased percentage of premature deliveries (n = 17, 15%) mainly due to preterm premature rupture of membranes and cervical incompetence and a markedly increased combined fetal and neonatal mortality of 7.1%. An obstetric and/ or neonatal complication occurred in a similar proportion of pregnancies in women with a diagnosis of Marfan syndrome before pregnancy versus women with a diagnosis of Marfan syndrome after pregnancy (39% vs. 41%, p = 0.85, respectively). Conclusion: In addition to cardiovascular complications, pregnancy in women with Marfan syndrome is associated with a high rate of premature deliveries, preterm premature rupture of membranes and increased mortality in the offspring.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalInternational Journal of Cardiology
Volume110
Issue number1
DOIs
Publication statusPublished - 7 Jun 2006

Cite this

Meijboom, L. J., Drenthen, W., Pieper, P. G., Groenink, M., van der Post, J. A. M., Timmermans, J., ... Mulder, B. J. M. (2006). Obstetric complications in Marfan syndrome. International Journal of Cardiology, 110(1), 53-59. https://doi.org/10.1016/j.ijcard.2005.07.017