Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study

Ines Rombach; Marvi Iftikhar; Gurleen S. Jhuti; Anders Gustavsson; Pascal Lecomte; Mark Belger; Ron Handels; Amparo Y. Castro Sanchez; Jan Kors; Louise Hopper; Marcel Olde Rikkert; Geir Selbæk; Astrid Stephan; Sietske A. M. Sikkes; Bob Woods; Manuel Gonçalves-Pereira; Orazio Zanetti; Inez H. G. B. Ramakers; Frans R. J. Verhey; John Gallacher; ROADMAP Consortium; null Actifcare Consortium; null LeARN Consortium; Filipa Landeiro; Alastair M. Gray

doi:10.1007/s11136-020-02670-8

Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study

Ines Rombach^*, Marvi Iftikhar, Gurleen S. Jhuti, Anders Gustavsson, Pascal Lecomte, Mark Belger, Ron Handels, Amparo Y. Castro Sanchez, Jan Kors, Louise Hopper, Marcel Olde Rikkert, Geir Selbæk, Astrid Stephan, Sietske A. M. Sikkes, Bob Woods, Manuel Gonçalves-Pereira, Orazio Zanetti, Inez H. G. B. Ramakers, Frans R. J. Verhey, John GallacherROADMAP Consortium, Actifcare Consortium, LeARN Consortium, Filipa Landeiro, Alastair M. Gray

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available. Methods: Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error. Results: The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset. Conclusions: The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.

Original language	English
Journal	Quality of Life Research
Early online date	2020
DOIs	https://doi.org/10.1007/s11136-020-02670-8
Publication status	E-pub ahead of print - 2020

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10.1007/s11136-020-02670-8

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Rombach, I., Iftikhar, M., Jhuti, G. S., Gustavsson, A., Lecomte, P., Belger, M., Handels, R., Castro Sanchez, A. Y., Kors, J., Hopper, L., Olde Rikkert, M., Selbæk, G., Stephan, A., Sikkes, S. A. M., Woods, B., Gonçalves-Pereira, M., Zanetti, O., Ramakers, I. H. G. B., Verhey, F. R. J., ... Gray, A. M. (2020). Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study. Quality of Life Research. https://doi.org/10.1007/s11136-020-02670-8

Rombach, Ines ; Iftikhar, Marvi ; Jhuti, Gurleen S. ; Gustavsson, Anders ; Lecomte, Pascal ; Belger, Mark ; Handels, Ron ; Castro Sanchez, Amparo Y. ; Kors, Jan ; Hopper, Louise ; Olde Rikkert, Marcel ; Selbæk, Geir ; Stephan, Astrid ; Sikkes, Sietske A. M. ; Woods, Bob ; Gonçalves-Pereira, Manuel ; Zanetti, Orazio ; Ramakers, Inez H. G. B. ; Verhey, Frans R. J. ; Gallacher, John ; ROADMAP Consortium ; Actifcare Consortium ; LeARN Consortium ; Landeiro, Filipa ; Gray, Alastair M. / Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study. In: Quality of Life Research. 2020.

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title = "Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer{\textquoteright}s disease scale: development and results from a mapping study",

abstract = "Purpose: The Quality of Life Alzheimer{\textquoteright}s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available. Methods: Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error. Results: The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset. Conclusions: The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.",

keywords = "Cross-walking, Dementia, Health related quality of life, Mapping algorithm, Preference based measures",

author = "Ines Rombach and Marvi Iftikhar and Jhuti, {Gurleen S.} and Anders Gustavsson and Pascal Lecomte and Mark Belger and Ron Handels and {Castro Sanchez}, {Amparo Y.} and Jan Kors and Louise Hopper and {Olde Rikkert}, Marcel and Geir Selb{\ae}k and Astrid Stephan and Sikkes, {Sietske A. M.} and Bob Woods and Manuel Gon{\c c}alves-Pereira and Orazio Zanetti and Ramakers, {Inez H. G. B.} and Verhey, {Frans R. J.} and John Gallacher and {ROADMAP Consortium} and {Actifcare Consortium} and {LeARN Consortium} and Filipa Landeiro and Gray, {Alastair M.}",

year = "2020",

doi = "10.1007/s11136-020-02670-8",

language = "English",

journal = "Quality of Life Research",

issn = "0962-9343",

publisher = "Springer Netherlands",

}

Rombach, I, Iftikhar, M, Jhuti, GS, Gustavsson, A, Lecomte, P, Belger, M, Handels, R, Castro Sanchez, AY, Kors, J, Hopper, L, Olde Rikkert, M, Selbæk, G, Stephan, A, Sikkes, SAM, Woods, B, Gonçalves-Pereira, M, Zanetti, O, Ramakers, IHGB, Verhey, FRJ, Gallacher, J, ROADMAP Consortium, Actifcare Consortium, LeARN Consortium, Landeiro, F & Gray, AM 2020, 'Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study', Quality of Life Research. https://doi.org/10.1007/s11136-020-02670-8

Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study. / Rombach, Ines; Iftikhar, Marvi; Jhuti, Gurleen S.; Gustavsson, Anders; Lecomte, Pascal; Belger, Mark; Handels, Ron; Castro Sanchez, Amparo Y.; Kors, Jan; Hopper, Louise; Olde Rikkert, Marcel; Selbæk, Geir; Stephan, Astrid; Sikkes, Sietske A. M.; Woods, Bob; Gonçalves-Pereira, Manuel; Zanetti, Orazio; Ramakers, Inez H. G. B.; Verhey, Frans R. J.; Gallacher, John; ROADMAP Consortium; Actifcare Consortium; LeARN Consortium; Landeiro, Filipa; Gray, Alastair M.

In: Quality of Life Research, 2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study

AU - Rombach, Ines

AU - Iftikhar, Marvi

AU - Jhuti, Gurleen S.

AU - Gustavsson, Anders

AU - Lecomte, Pascal

AU - Belger, Mark

AU - Handels, Ron

AU - Castro Sanchez, Amparo Y.

AU - Kors, Jan

AU - Hopper, Louise

AU - Olde Rikkert, Marcel

AU - Selbæk, Geir

AU - Stephan, Astrid

AU - Sikkes, Sietske A. M.

AU - Woods, Bob

AU - Gonçalves-Pereira, Manuel

AU - Zanetti, Orazio

AU - Ramakers, Inez H. G. B.

AU - Verhey, Frans R. J.

AU - Gallacher, John

AU - ROADMAP Consortium

AU - Actifcare Consortium, null

AU - LeARN Consortium, null

AU - Landeiro, Filipa

AU - Gray, Alastair M.

PY - 2020

Y1 - 2020

N2 - Purpose: The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available. Methods: Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error. Results: The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset. Conclusions: The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.

AB - Purpose: The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available. Methods: Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error. Results: The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset. Conclusions: The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.

KW - Cross-walking

KW - Dementia

KW - Health related quality of life

KW - Mapping algorithm

KW - Preference based measures

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UR - https://www.ncbi.nlm.nih.gov/pubmed/33068236

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DO - 10.1007/s11136-020-02670-8

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JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

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