Oil-based or water-based contrast for hysterosalpingography in infertile women

Kim Dreyer, Joukje Van Rijswijk, Velja Mijatovic, Mariëtte Goddijn, Harold R. Verhoeve, Ilse A.J. Van Rooij, Annemieke Hoek, Petra Bourdrez, Annemiek W. Nap, Henrike G.M. Rijnsaardt-Lukassen, Catharina C.M. Timmerman, Mesrure Kaplan, Angelo B. Hooker, Anna P. Gijsen, Ron Van Golde, Cathelijne F. Van Heteren, Alexander V. Sluijmer, Jan Peter De Bruin, Jesper M.J. Smeenk, Jacoba A.M. De Boer & 12 others Eduard Scheenjes, Annette E.J. Duijn, Alexander Mozes, Marie J. Pelinck, Maaike A.F. Traas, Machiel H.A. Van Hooff, Gijsbertus A. Van Unnik, Cornelia H. De Koning, Nan Van Geloven, Jos W.R. Twisk, Peter G.A. Hompes, Ben W.J. Mol

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND Pregnancy rates among infertile women have been reported to increase after hysterosalpingography, but it is unclear whether the type of contrast medium used (oil-based or water-soluble contrast) influences this potential therapeutic effect. METHODSWe performed a multicenter, randomized trial in 27 hospitals in the Netherlands in which infertile women who were undergoing hysterosalpingography were randomly assigned to undergo this procedure with the use of oil-based or water-based contrast. Subsequently, couples received expectant management or the women underwent intrauterine insemination. The primary outcome was ongoing pregnancy within 6 months after randomization. Outcomes were analyzed according to the intention-to-treat principle. RESULTSA total of 1119 women were randomly assigned to hysterosalpingography with oil contrast (557 women) or water contrast (562 women). A total of 220 of 554 women in the oil group (39.7%) and 161 of 554 women in the water group (29.1%) had an ongoing pregnancy (rate ratio, 1.37; 95% confidence interval [CI], 1.16 to 1.61; <0.001), and 214 of 552 women in the oil group (38.8%) and 155 of 552 women in the water group (28.1%) had live births (rate ratio, 1.38; 95% CI, 1.17 to 1.64; <0.001). Rates of adverse events were low and similar in the two groups. CONCLUSIONSRates of ongoing pregnancy and live births were higher among women who underwent hysterosalpingography with oil contrast than among women who underwent this procedure with water contrast. (Netherlands Trial Register number, NTR3270.).

Original languageEnglish
Pages (from-to)2043-2052
Number of pages10
JournalNew England Journal of Medicine
Volume376
Issue number21
DOIs
Publication statusPublished - 25 May 2017

Cite this

Dreyer, K., Van Rijswijk, J., Mijatovic, V., Goddijn, M., Verhoeve, H. R., Van Rooij, I. A. J., ... Mol, B. W. J. (2017). Oil-based or water-based contrast for hysterosalpingography in infertile women. New England Journal of Medicine, 376(21), 2043-2052. https://doi.org/10.1056/NEJMoa1612337
Dreyer, Kim ; Van Rijswijk, Joukje ; Mijatovic, Velja ; Goddijn, Mariëtte ; Verhoeve, Harold R. ; Van Rooij, Ilse A.J. ; Hoek, Annemieke ; Bourdrez, Petra ; Nap, Annemiek W. ; Rijnsaardt-Lukassen, Henrike G.M. ; Timmerman, Catharina C.M. ; Kaplan, Mesrure ; Hooker, Angelo B. ; Gijsen, Anna P. ; Van Golde, Ron ; Van Heteren, Cathelijne F. ; Sluijmer, Alexander V. ; De Bruin, Jan Peter ; Smeenk, Jesper M.J. ; De Boer, Jacoba A.M. ; Scheenjes, Eduard ; Duijn, Annette E.J. ; Mozes, Alexander ; Pelinck, Marie J. ; Traas, Maaike A.F. ; Van Hooff, Machiel H.A. ; Van Unnik, Gijsbertus A. ; De Koning, Cornelia H. ; Van Geloven, Nan ; Twisk, Jos W.R. ; Hompes, Peter G.A. ; Mol, Ben W.J. / Oil-based or water-based contrast for hysterosalpingography in infertile women. In: New England Journal of Medicine. 2017 ; Vol. 376, No. 21. pp. 2043-2052.
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title = "Oil-based or water-based contrast for hysterosalpingography in infertile women",
abstract = "BACKGROUND Pregnancy rates among infertile women have been reported to increase after hysterosalpingography, but it is unclear whether the type of contrast medium used (oil-based or water-soluble contrast) influences this potential therapeutic effect. METHODSWe performed a multicenter, randomized trial in 27 hospitals in the Netherlands in which infertile women who were undergoing hysterosalpingography were randomly assigned to undergo this procedure with the use of oil-based or water-based contrast. Subsequently, couples received expectant management or the women underwent intrauterine insemination. The primary outcome was ongoing pregnancy within 6 months after randomization. Outcomes were analyzed according to the intention-to-treat principle. RESULTSA total of 1119 women were randomly assigned to hysterosalpingography with oil contrast (557 women) or water contrast (562 women). A total of 220 of 554 women in the oil group (39.7{\%}) and 161 of 554 women in the water group (29.1{\%}) had an ongoing pregnancy (rate ratio, 1.37; 95{\%} confidence interval [CI], 1.16 to 1.61; <0.001), and 214 of 552 women in the oil group (38.8{\%}) and 155 of 552 women in the water group (28.1{\%}) had live births (rate ratio, 1.38; 95{\%} CI, 1.17 to 1.64; <0.001). Rates of adverse events were low and similar in the two groups. CONCLUSIONSRates of ongoing pregnancy and live births were higher among women who underwent hysterosalpingography with oil contrast than among women who underwent this procedure with water contrast. (Netherlands Trial Register number, NTR3270.).",
author = "Kim Dreyer and {Van Rijswijk}, Joukje and Velja Mijatovic and Mari{\"e}tte Goddijn and Verhoeve, {Harold R.} and {Van Rooij}, {Ilse A.J.} and Annemieke Hoek and Petra Bourdrez and Nap, {Annemiek W.} and Rijnsaardt-Lukassen, {Henrike G.M.} and Timmerman, {Catharina C.M.} and Mesrure Kaplan and Hooker, {Angelo B.} and Gijsen, {Anna P.} and {Van Golde}, Ron and {Van Heteren}, {Cathelijne F.} and Sluijmer, {Alexander V.} and {De Bruin}, {Jan Peter} and Smeenk, {Jesper M.J.} and {De Boer}, {Jacoba A.M.} and Eduard Scheenjes and Duijn, {Annette E.J.} and Alexander Mozes and Pelinck, {Marie J.} and Traas, {Maaike A.F.} and {Van Hooff}, {Machiel H.A.} and {Van Unnik}, {Gijsbertus A.} and {De Koning}, {Cornelia H.} and {Van Geloven}, Nan and Twisk, {Jos W.R.} and Hompes, {Peter G.A.} and Mol, {Ben W.J.}",
year = "2017",
month = "5",
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language = "English",
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pages = "2043--2052",
journal = "New England Journal of Medicine",
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Dreyer, K, Van Rijswijk, J, Mijatovic, V, Goddijn, M, Verhoeve, HR, Van Rooij, IAJ, Hoek, A, Bourdrez, P, Nap, AW, Rijnsaardt-Lukassen, HGM, Timmerman, CCM, Kaplan, M, Hooker, AB, Gijsen, AP, Van Golde, R, Van Heteren, CF, Sluijmer, AV, De Bruin, JP, Smeenk, JMJ, De Boer, JAM, Scheenjes, E, Duijn, AEJ, Mozes, A, Pelinck, MJ, Traas, MAF, Van Hooff, MHA, Van Unnik, GA, De Koning, CH, Van Geloven, N, Twisk, JWR, Hompes, PGA & Mol, BWJ 2017, 'Oil-based or water-based contrast for hysterosalpingography in infertile women' New England Journal of Medicine, vol. 376, no. 21, pp. 2043-2052. https://doi.org/10.1056/NEJMoa1612337

Oil-based or water-based contrast for hysterosalpingography in infertile women. / Dreyer, Kim; Van Rijswijk, Joukje; Mijatovic, Velja; Goddijn, Mariëtte; Verhoeve, Harold R.; Van Rooij, Ilse A.J.; Hoek, Annemieke; Bourdrez, Petra; Nap, Annemiek W.; Rijnsaardt-Lukassen, Henrike G.M.; Timmerman, Catharina C.M.; Kaplan, Mesrure; Hooker, Angelo B.; Gijsen, Anna P.; Van Golde, Ron; Van Heteren, Cathelijne F.; Sluijmer, Alexander V.; De Bruin, Jan Peter; Smeenk, Jesper M.J.; De Boer, Jacoba A.M.; Scheenjes, Eduard; Duijn, Annette E.J.; Mozes, Alexander; Pelinck, Marie J.; Traas, Maaike A.F.; Van Hooff, Machiel H.A.; Van Unnik, Gijsbertus A.; De Koning, Cornelia H.; Van Geloven, Nan; Twisk, Jos W.R.; Hompes, Peter G.A.; Mol, Ben W.J.

In: New England Journal of Medicine, Vol. 376, No. 21, 25.05.2017, p. 2043-2052.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Oil-based or water-based contrast for hysterosalpingography in infertile women

AU - Dreyer, Kim

AU - Van Rijswijk, Joukje

AU - Mijatovic, Velja

AU - Goddijn, Mariëtte

AU - Verhoeve, Harold R.

AU - Van Rooij, Ilse A.J.

AU - Hoek, Annemieke

AU - Bourdrez, Petra

AU - Nap, Annemiek W.

AU - Rijnsaardt-Lukassen, Henrike G.M.

AU - Timmerman, Catharina C.M.

AU - Kaplan, Mesrure

AU - Hooker, Angelo B.

AU - Gijsen, Anna P.

AU - Van Golde, Ron

AU - Van Heteren, Cathelijne F.

AU - Sluijmer, Alexander V.

AU - De Bruin, Jan Peter

AU - Smeenk, Jesper M.J.

AU - De Boer, Jacoba A.M.

AU - Scheenjes, Eduard

AU - Duijn, Annette E.J.

AU - Mozes, Alexander

AU - Pelinck, Marie J.

AU - Traas, Maaike A.F.

AU - Van Hooff, Machiel H.A.

AU - Van Unnik, Gijsbertus A.

AU - De Koning, Cornelia H.

AU - Van Geloven, Nan

AU - Twisk, Jos W.R.

AU - Hompes, Peter G.A.

AU - Mol, Ben W.J.

PY - 2017/5/25

Y1 - 2017/5/25

N2 - BACKGROUND Pregnancy rates among infertile women have been reported to increase after hysterosalpingography, but it is unclear whether the type of contrast medium used (oil-based or water-soluble contrast) influences this potential therapeutic effect. METHODSWe performed a multicenter, randomized trial in 27 hospitals in the Netherlands in which infertile women who were undergoing hysterosalpingography were randomly assigned to undergo this procedure with the use of oil-based or water-based contrast. Subsequently, couples received expectant management or the women underwent intrauterine insemination. The primary outcome was ongoing pregnancy within 6 months after randomization. Outcomes were analyzed according to the intention-to-treat principle. RESULTSA total of 1119 women were randomly assigned to hysterosalpingography with oil contrast (557 women) or water contrast (562 women). A total of 220 of 554 women in the oil group (39.7%) and 161 of 554 women in the water group (29.1%) had an ongoing pregnancy (rate ratio, 1.37; 95% confidence interval [CI], 1.16 to 1.61; <0.001), and 214 of 552 women in the oil group (38.8%) and 155 of 552 women in the water group (28.1%) had live births (rate ratio, 1.38; 95% CI, 1.17 to 1.64; <0.001). Rates of adverse events were low and similar in the two groups. CONCLUSIONSRates of ongoing pregnancy and live births were higher among women who underwent hysterosalpingography with oil contrast than among women who underwent this procedure with water contrast. (Netherlands Trial Register number, NTR3270.).

AB - BACKGROUND Pregnancy rates among infertile women have been reported to increase after hysterosalpingography, but it is unclear whether the type of contrast medium used (oil-based or water-soluble contrast) influences this potential therapeutic effect. METHODSWe performed a multicenter, randomized trial in 27 hospitals in the Netherlands in which infertile women who were undergoing hysterosalpingography were randomly assigned to undergo this procedure with the use of oil-based or water-based contrast. Subsequently, couples received expectant management or the women underwent intrauterine insemination. The primary outcome was ongoing pregnancy within 6 months after randomization. Outcomes were analyzed according to the intention-to-treat principle. RESULTSA total of 1119 women were randomly assigned to hysterosalpingography with oil contrast (557 women) or water contrast (562 women). A total of 220 of 554 women in the oil group (39.7%) and 161 of 554 women in the water group (29.1%) had an ongoing pregnancy (rate ratio, 1.37; 95% confidence interval [CI], 1.16 to 1.61; <0.001), and 214 of 552 women in the oil group (38.8%) and 155 of 552 women in the water group (28.1%) had live births (rate ratio, 1.38; 95% CI, 1.17 to 1.64; <0.001). Rates of adverse events were low and similar in the two groups. CONCLUSIONSRates of ongoing pregnancy and live births were higher among women who underwent hysterosalpingography with oil contrast than among women who underwent this procedure with water contrast. (Netherlands Trial Register number, NTR3270.).

UR - http://www.scopus.com/inward/record.url?scp=85019831765&partnerID=8YFLogxK

U2 - 10.1056/NEJMoa1612337

DO - 10.1056/NEJMoa1612337

M3 - Article

VL - 376

SP - 2043

EP - 2052

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 21

ER -