Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants

Hellen Houlleberghs; Marleen Dekker; Hildo Lantermans; Roos Kleinendorst; Hendrikus Jan Dubbink; Robert M. W. Hofstra; Senno Verhoef; Hein te Riele

doi:10.1073/pnas.1520813113

Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants

Hellen Houlleberghs, Marleen Dekker, Hildo Lantermans, Roos Kleinendorst, Hendrikus Jan Dubbink, Robert M. W. Hofstra, Senno Verhoef, Hein te Riele

Clinical genetics

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	4128-4133
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	113
Issue number	15
DOIs	https://doi.org/10.1073/pnas.1520813113
Publication status	Published - 12 Apr 2016

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10.1073/pnas.1520813113

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Houlleberghs, H., Dekker, M., Lantermans, H., Kleinendorst, R., Dubbink, H. J., Hofstra, R. M. W., Verhoef, S., & te Riele, H. (2016). Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants. Proceedings of the National Academy of Sciences of the United States of America, 113(15), 4128-4133. https://doi.org/10.1073/pnas.1520813113

Houlleberghs, Hellen ; Dekker, Marleen ; Lantermans, Hildo ; Kleinendorst, Roos ; Dubbink, Hendrikus Jan ; Hofstra, Robert M. W. ; Verhoef, Senno ; te Riele, Hein. / Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 15. pp. 4128-4133.

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title = "Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants",

keywords = "Lynch syndrome, DNA mismatch repair, MSH2, variants of uncertain significance, site-directed mutagenesis",

author = "Hellen Houlleberghs and Marleen Dekker and Hildo Lantermans and Roos Kleinendorst and Dubbink, {Hendrikus Jan} and Hofstra, {Robert M. W.} and Senno Verhoef and {te Riele}, Hein",

year = "2016",

month = apr,

day = "12",

doi = "10.1073/pnas.1520813113",

language = "English",

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Houlleberghs, H, Dekker, M, Lantermans, H, Kleinendorst, R, Dubbink, HJ, Hofstra, RMW, Verhoef, S & te Riele, H 2016, 'Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 15, pp. 4128-4133. https://doi.org/10.1073/pnas.1520813113

Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants. / Houlleberghs, Hellen; Dekker, Marleen; Lantermans, Hildo; Kleinendorst, Roos; Dubbink, Hendrikus Jan; Hofstra, Robert M. W.; Verhoef, Senno; te Riele, Hein.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 15, 12.04.2016, p. 4128-4133.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants

AU - Houlleberghs, Hellen

AU - Dekker, Marleen

AU - Lantermans, Hildo

AU - Kleinendorst, Roos

AU - Dubbink, Hendrikus Jan

AU - Hofstra, Robert M. W.

AU - Verhoef, Senno

AU - te Riele, Hein

PY - 2016/4/12

Y1 - 2016/4/12

KW - Lynch syndrome

KW - DNA mismatch repair

KW - MSH2

KW - variants of uncertain significance

KW - site-directed mutagenesis

U2 - 10.1073/pnas.1520813113

DO - 10.1073/pnas.1520813113

M3 - Article

C2 - 26951660

VL - 113

SP - 4128

EP - 4133

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 15

ER -

Houlleberghs H, Dekker M, Lantermans H, Kleinendorst R, Dubbink HJ, Hofstra RMW et al. Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants. Proceedings of the National Academy of Sciences of the United States of America. 2016 Apr 12;113(15):4128-4133. https://doi.org/10.1073/pnas.1520813113