A series of 11C-labeled ureas was prepared using a rapid and efficient one-pot procedure. First, the intermediate [11C] phenylisocyanate was formed with phenyltriphenylphosphinimine and [ 11C]CO2. A range of amines was then reacted with the [11C]phenylisocyanate yielding the [11C]urea derivatives in short synthesis times. This easy-to-handle method circumvents disadvantages of known procedures and generates the possibility to prepare other kinds of 11C-labeled compounds using a variety of phenylphosphinimines in combination with different nucleophiles. The presented approach is an alternative to the use of established methods in 11C-labeling chemistry.
|Number of pages||10|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Publication status||Published - 30 Mar 2006|