One-pot synthesis of [11C]ureas via triphenylphosphinimines

Erica W. Van Tilburg*, Albert D. Windhorst, Margreet Van Der Mey, Jacobus D.M. Herscheid

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A series of 11C-labeled ureas was prepared using a rapid and efficient one-pot procedure. First, the intermediate [11C] phenylisocyanate was formed with phenyltriphenylphosphinimine and [ 11C]CO2. A range of amines was then reacted with the [11C]phenylisocyanate yielding the [11C]urea derivatives in short synthesis times. This easy-to-handle method circumvents disadvantages of known procedures and generates the possibility to prepare other kinds of 11C-labeled compounds using a variety of phenylphosphinimines in combination with different nucleophiles. The presented approach is an alternative to the use of established methods in 11C-labeling chemistry.

Original languageEnglish
Pages (from-to)321-330
Number of pages10
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume49
Issue number4
DOIs
Publication statusPublished - 30 Mar 2006

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