Abstract

Background/aims: As a protrusion from the brain, the retina might reflect the status of the brain. Previous studies showed a decrease in vessel density and foveal avascular zone (FAZ) enlargement on optical coherence tomography angiography (OCTA) in individuals suffering from Alzheimer's disease (AD). This study aims to assess whether such changes are already present in preclinical stages of AD, in a population of monozygotic (MZ) twins. Methods: 124 cognitively healthy individuals (MZ twins, ages 60-93 years) underwent [18F]flutemetamol amyloid positron emission tomography (PET) scanning and OCTA. PET scans were visually rated for cortical amyloid-beta (Aβ) positivity. Parametric global cortical non-displaceable binding potential (BPND) was used as a continuous measure for Aβ aggregation. FAZ size and vessel densities for the inner and outer ring of the macular ETDRS grid and in a 3-6 mm ring around the optic nerve head (ONH) were measured. OCTA measures were associated with visual Aβ score, BPND and amyloid load estimated by twin concordance on visual Aβ score. Twin correlations were estimated as a measure of maximum heritability of OCTA measures. Results: 13 of 124 participants were Aβ+. Aβ+ individuals had significantly higher vessel density than Aβ-individuals in all regions but did not differ in FAZ size. Twin analyses showed a positive association between and vessel densities in all regions. BPND tended to be associated with higher vessel density in the inner ring. Twin correlations were moderate/high for all OCTA parameters except vessel density around the ONH, which correlated weakly. Conclusion: Retinal vessel density was higher in individuals with preclinical AD.
Original languageEnglish
JournalBritish Journal of Ophthalmology
Early online date22 May 2019
DOIs
Publication statusPublished - 2019

Cite this

@article{7746494264114b13a2c4c2ee379ae961,
title = "Optical coherence tomography angiography in preclinical Alzheimer's disease",
abstract = "Background/aims: As a protrusion from the brain, the retina might reflect the status of the brain. Previous studies showed a decrease in vessel density and foveal avascular zone (FAZ) enlargement on optical coherence tomography angiography (OCTA) in individuals suffering from Alzheimer's disease (AD). This study aims to assess whether such changes are already present in preclinical stages of AD, in a population of monozygotic (MZ) twins. Methods: 124 cognitively healthy individuals (MZ twins, ages 60-93 years) underwent [18F]flutemetamol amyloid positron emission tomography (PET) scanning and OCTA. PET scans were visually rated for cortical amyloid-beta (Aβ) positivity. Parametric global cortical non-displaceable binding potential (BPND) was used as a continuous measure for Aβ aggregation. FAZ size and vessel densities for the inner and outer ring of the macular ETDRS grid and in a 3-6 mm ring around the optic nerve head (ONH) were measured. OCTA measures were associated with visual Aβ score, BPND and amyloid load estimated by twin concordance on visual Aβ score. Twin correlations were estimated as a measure of maximum heritability of OCTA measures. Results: 13 of 124 participants were Aβ+. Aβ+ individuals had significantly higher vessel density than Aβ-individuals in all regions but did not differ in FAZ size. Twin analyses showed a positive association between and vessel densities in all regions. BPND tended to be associated with higher vessel density in the inner ring. Twin correlations were moderate/high for all OCTA parameters except vessel density around the ONH, which correlated weakly. Conclusion: Retinal vessel density was higher in individuals with preclinical AD.",
keywords = "diagnostic tests/investigation, imaging, retina",
author = "{van de Kreeke}, {Jacoba Alida} and Hoang-Ton Nguyen and Elles Konijnenberg and Jori Tomassen and {den Braber}, Anouk and {ten Kate}, Mara and Maqsood Yaqub and {van Berckel}, Bart and Lammertsma, {Adriaan A.} and Boomsma, {Dorret I.} and Tan, {Stevie H.} and Frank Verbraak and Visser, {Pieter Jelle}",
note = "{\circledC} Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
doi = "10.1136/bjophthalmol-2019-314127",
language = "English",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",

}

TY - JOUR

T1 - Optical coherence tomography angiography in preclinical Alzheimer's disease

AU - van de Kreeke, Jacoba Alida

AU - Nguyen, Hoang-Ton

AU - Konijnenberg, Elles

AU - Tomassen, Jori

AU - den Braber, Anouk

AU - ten Kate, Mara

AU - Yaqub, Maqsood

AU - van Berckel, Bart

AU - Lammertsma, Adriaan A.

AU - Boomsma, Dorret I.

AU - Tan, Stevie H.

AU - Verbraak, Frank

AU - Visser, Pieter Jelle

N1 - © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019

Y1 - 2019

N2 - Background/aims: As a protrusion from the brain, the retina might reflect the status of the brain. Previous studies showed a decrease in vessel density and foveal avascular zone (FAZ) enlargement on optical coherence tomography angiography (OCTA) in individuals suffering from Alzheimer's disease (AD). This study aims to assess whether such changes are already present in preclinical stages of AD, in a population of monozygotic (MZ) twins. Methods: 124 cognitively healthy individuals (MZ twins, ages 60-93 years) underwent [18F]flutemetamol amyloid positron emission tomography (PET) scanning and OCTA. PET scans were visually rated for cortical amyloid-beta (Aβ) positivity. Parametric global cortical non-displaceable binding potential (BPND) was used as a continuous measure for Aβ aggregation. FAZ size and vessel densities for the inner and outer ring of the macular ETDRS grid and in a 3-6 mm ring around the optic nerve head (ONH) were measured. OCTA measures were associated with visual Aβ score, BPND and amyloid load estimated by twin concordance on visual Aβ score. Twin correlations were estimated as a measure of maximum heritability of OCTA measures. Results: 13 of 124 participants were Aβ+. Aβ+ individuals had significantly higher vessel density than Aβ-individuals in all regions but did not differ in FAZ size. Twin analyses showed a positive association between and vessel densities in all regions. BPND tended to be associated with higher vessel density in the inner ring. Twin correlations were moderate/high for all OCTA parameters except vessel density around the ONH, which correlated weakly. Conclusion: Retinal vessel density was higher in individuals with preclinical AD.

AB - Background/aims: As a protrusion from the brain, the retina might reflect the status of the brain. Previous studies showed a decrease in vessel density and foveal avascular zone (FAZ) enlargement on optical coherence tomography angiography (OCTA) in individuals suffering from Alzheimer's disease (AD). This study aims to assess whether such changes are already present in preclinical stages of AD, in a population of monozygotic (MZ) twins. Methods: 124 cognitively healthy individuals (MZ twins, ages 60-93 years) underwent [18F]flutemetamol amyloid positron emission tomography (PET) scanning and OCTA. PET scans were visually rated for cortical amyloid-beta (Aβ) positivity. Parametric global cortical non-displaceable binding potential (BPND) was used as a continuous measure for Aβ aggregation. FAZ size and vessel densities for the inner and outer ring of the macular ETDRS grid and in a 3-6 mm ring around the optic nerve head (ONH) were measured. OCTA measures were associated with visual Aβ score, BPND and amyloid load estimated by twin concordance on visual Aβ score. Twin correlations were estimated as a measure of maximum heritability of OCTA measures. Results: 13 of 124 participants were Aβ+. Aβ+ individuals had significantly higher vessel density than Aβ-individuals in all regions but did not differ in FAZ size. Twin analyses showed a positive association between and vessel densities in all regions. BPND tended to be associated with higher vessel density in the inner ring. Twin correlations were moderate/high for all OCTA parameters except vessel density around the ONH, which correlated weakly. Conclusion: Retinal vessel density was higher in individuals with preclinical AD.

KW - diagnostic tests/investigation

KW - imaging

KW - retina

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066759830&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31118186

U2 - 10.1136/bjophthalmol-2019-314127

DO - 10.1136/bjophthalmol-2019-314127

M3 - Article

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

ER -