Optimizing SABR delivery for synchronous multiple lung tumors using volumetric-modulated arc therapy

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Volumetric-modulated arc therapy (VMAT) delivery for stereotactic ablative radiotherapy (SABR) of multiple lung tumors allows for faster treatments. We report on clinical outcomes and describe a general approach for treatment planning. Material and methods: Patients undergoing multi iso-center VMAT-based SABR for ≥2 lung lesions between 2009 and 2014 were identified from the VU University Medical Center and London Health Sciences Centre. Patients were eligible if the start date of the SABR treatment for the different lesions was within a time range of 30 days. SABR was delivered using separate iso-centers for lesions at a substantial distance from each other. Tumors were either treated with a single fraction of 34 Gy, or using three risk-adapted dose-fractionation schemes, namely three fractions of 18 Gy, five fractions of 11 Gy, or eight fractions of 7.5 Gy, depending on the tumor size and the location. Multivariable analysis was performed to assess factors predictive of clinical outcomes. Results: Of 84 patients (188 lesions) identified, 46% were treated for multiple metastases and 54% for multiple primary NSCLC. About 97% were treated for two or three lesions, and 56% had bilateral disease. After a median follow-up of 28 months, median overall survival (OS) for primary tumors was 27.6 months, and not reached for metastatic lesions (p =.028). Grade ≥3 toxicity was observed in 2% of patients. Multivariable analysis showed that grade 2 or higher radiation pneumonitis (n = 9) was best predicted by a total lung V35Gy of ≥6.5% (in 2Gy/fraction equivalent) (p =.007). Conclusion: Severe toxicity was uncommon following SABR using VMAT for up to three lung tumors. Further investigations of planning parameters are needed in patients presenting with more lesions.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalActa Oncologica
Volume56
Issue number4
DOIs
Publication statusPublished - 3 Apr 2017

Cite this

@article{6643d1ddb51247a197ed066f089243bf,
title = "Optimizing SABR delivery for synchronous multiple lung tumors using volumetric-modulated arc therapy",
abstract = "Background: Volumetric-modulated arc therapy (VMAT) delivery for stereotactic ablative radiotherapy (SABR) of multiple lung tumors allows for faster treatments. We report on clinical outcomes and describe a general approach for treatment planning. Material and methods: Patients undergoing multi iso-center VMAT-based SABR for ≥2 lung lesions between 2009 and 2014 were identified from the VU University Medical Center and London Health Sciences Centre. Patients were eligible if the start date of the SABR treatment for the different lesions was within a time range of 30 days. SABR was delivered using separate iso-centers for lesions at a substantial distance from each other. Tumors were either treated with a single fraction of 34 Gy, or using three risk-adapted dose-fractionation schemes, namely three fractions of 18 Gy, five fractions of 11 Gy, or eight fractions of 7.5 Gy, depending on the tumor size and the location. Multivariable analysis was performed to assess factors predictive of clinical outcomes. Results: Of 84 patients (188 lesions) identified, 46{\%} were treated for multiple metastases and 54{\%} for multiple primary NSCLC. About 97{\%} were treated for two or three lesions, and 56{\%} had bilateral disease. After a median follow-up of 28 months, median overall survival (OS) for primary tumors was 27.6 months, and not reached for metastatic lesions (p =.028). Grade ≥3 toxicity was observed in 2{\%} of patients. Multivariable analysis showed that grade 2 or higher radiation pneumonitis (n = 9) was best predicted by a total lung V35Gy of ≥6.5{\%} (in 2Gy/fraction equivalent) (p =.007). Conclusion: Severe toxicity was uncommon following SABR using VMAT for up to three lung tumors. Further investigations of planning parameters are needed in patients presenting with more lesions.",
author = "Hil{\^a}l Tekatli and Tetar, {Shyama U.} and Nguyen, {Timothy K.} and Andrew Warner and Verbakel, {Wilko F.} and Palma, {David A.} and Max Dahele and Stewart Gaede and Cornelis Haasbeek and Spoelstra, {Femke O.} and {de Haan}, {Patricia F.} and Slotman, {Ben J.} and Suresh Senan",
year = "2017",
month = "4",
day = "3",
doi = "10.1080/0284186X.2017.1295166",
language = "English",
volume = "56",
pages = "548--554",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Informa Healthcare",
number = "4",

}

Optimizing SABR delivery for synchronous multiple lung tumors using volumetric-modulated arc therapy. / Tekatli, Hilâl; Tetar, Shyama U.; Nguyen, Timothy K.; Warner, Andrew; Verbakel, Wilko F.; Palma, David A.; Dahele, Max; Gaede, Stewart; Haasbeek, Cornelis; Spoelstra, Femke O.; de Haan, Patricia F.; Slotman, Ben J.; Senan, Suresh.

In: Acta Oncologica, Vol. 56, No. 4, 03.04.2017, p. 548-554.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Optimizing SABR delivery for synchronous multiple lung tumors using volumetric-modulated arc therapy

AU - Tekatli, Hilâl

AU - Tetar, Shyama U.

AU - Nguyen, Timothy K.

AU - Warner, Andrew

AU - Verbakel, Wilko F.

AU - Palma, David A.

AU - Dahele, Max

AU - Gaede, Stewart

AU - Haasbeek, Cornelis

AU - Spoelstra, Femke O.

AU - de Haan, Patricia F.

AU - Slotman, Ben J.

AU - Senan, Suresh

PY - 2017/4/3

Y1 - 2017/4/3

N2 - Background: Volumetric-modulated arc therapy (VMAT) delivery for stereotactic ablative radiotherapy (SABR) of multiple lung tumors allows for faster treatments. We report on clinical outcomes and describe a general approach for treatment planning. Material and methods: Patients undergoing multi iso-center VMAT-based SABR for ≥2 lung lesions between 2009 and 2014 were identified from the VU University Medical Center and London Health Sciences Centre. Patients were eligible if the start date of the SABR treatment for the different lesions was within a time range of 30 days. SABR was delivered using separate iso-centers for lesions at a substantial distance from each other. Tumors were either treated with a single fraction of 34 Gy, or using three risk-adapted dose-fractionation schemes, namely three fractions of 18 Gy, five fractions of 11 Gy, or eight fractions of 7.5 Gy, depending on the tumor size and the location. Multivariable analysis was performed to assess factors predictive of clinical outcomes. Results: Of 84 patients (188 lesions) identified, 46% were treated for multiple metastases and 54% for multiple primary NSCLC. About 97% were treated for two or three lesions, and 56% had bilateral disease. After a median follow-up of 28 months, median overall survival (OS) for primary tumors was 27.6 months, and not reached for metastatic lesions (p =.028). Grade ≥3 toxicity was observed in 2% of patients. Multivariable analysis showed that grade 2 or higher radiation pneumonitis (n = 9) was best predicted by a total lung V35Gy of ≥6.5% (in 2Gy/fraction equivalent) (p =.007). Conclusion: Severe toxicity was uncommon following SABR using VMAT for up to three lung tumors. Further investigations of planning parameters are needed in patients presenting with more lesions.

AB - Background: Volumetric-modulated arc therapy (VMAT) delivery for stereotactic ablative radiotherapy (SABR) of multiple lung tumors allows for faster treatments. We report on clinical outcomes and describe a general approach for treatment planning. Material and methods: Patients undergoing multi iso-center VMAT-based SABR for ≥2 lung lesions between 2009 and 2014 were identified from the VU University Medical Center and London Health Sciences Centre. Patients were eligible if the start date of the SABR treatment for the different lesions was within a time range of 30 days. SABR was delivered using separate iso-centers for lesions at a substantial distance from each other. Tumors were either treated with a single fraction of 34 Gy, or using three risk-adapted dose-fractionation schemes, namely three fractions of 18 Gy, five fractions of 11 Gy, or eight fractions of 7.5 Gy, depending on the tumor size and the location. Multivariable analysis was performed to assess factors predictive of clinical outcomes. Results: Of 84 patients (188 lesions) identified, 46% were treated for multiple metastases and 54% for multiple primary NSCLC. About 97% were treated for two or three lesions, and 56% had bilateral disease. After a median follow-up of 28 months, median overall survival (OS) for primary tumors was 27.6 months, and not reached for metastatic lesions (p =.028). Grade ≥3 toxicity was observed in 2% of patients. Multivariable analysis showed that grade 2 or higher radiation pneumonitis (n = 9) was best predicted by a total lung V35Gy of ≥6.5% (in 2Gy/fraction equivalent) (p =.007). Conclusion: Severe toxicity was uncommon following SABR using VMAT for up to three lung tumors. Further investigations of planning parameters are needed in patients presenting with more lesions.

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U2 - 10.1080/0284186X.2017.1295166

DO - 10.1080/0284186X.2017.1295166

M3 - Article

VL - 56

SP - 548

EP - 554

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 4

ER -