OS 06-09 THE SYNERGISTIC ASSOCIATION BETWEEN VITAMIN D AND VITAMIN K WITH INCIDENT HYPERTENSION

Adriana Van Ballegooijen, Natasja Van Schoor, Ingeborg Brouwer, Marjolein Visser, Joline Beulens

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE Vitamin D plays an important role in calcium homeostasis. The role of vitamin D in bone and cardiovascular health has mainly been studied in isolation and the synergistic effect of vitamin D and vitamin K is largely unknown. We assessed whether serum 25-hydroxyvitamin D [25(OH)D] levels and dephosphorylated, uncarboxylated matrix Gla protein (dp-unMGP) levels -an established marker of vitamin K status- are associated with incident hypertension among older adults in the Netherlands. DESIGN AND METHOD We used data from the Longitudinal Aging Study Amsterdam (LASA), a population-based, prospective cohort with baseline measurements obtained between 2002 and 2003 and 3 follow-up exams. We studied 257 men and women, aged 55 to 65 years free of prevalent cardiovascular disease, hypertension and use of anti-hypertensive medication with follow-up data. We measured serum 25(OH)D and dp-ucMGP from previously frozen baseline samples. We used Cox-regression analyses to estimate hazard ratios and 95% confidence intervals for 25(OH)D and dp-ucMGP categories with incident hypertension through 2012 (blood pressure ≥140/90 mmHg or initiation of blood pressure-lowering drugs). RESULTS During a median follow-up of 6.1 years, 52% of the cohort (n = 133) developed hypertension. Mean ± SD serum concentration of 25(OH)D was 58.9 ± 22.3 nmol/L and median dp-ucMGP was 310 (IQR: 209-425) nmol/L. Compared with the category of 25(OH)D ≥50nmol/L and dp-ucMGP 
Original languageEnglish
Pages (from-to)e64
JournalJournal of Hypertension
Volume34
DOIs
Publication statusPublished - Sep 2016

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