Overall and Disease Related Mortality in Parkinson's Disease - A Longitudinal Cohort Study

Jeroen Hoogland*, Bart Post, Rob M.A. De Bie

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Earlier research showed that Parkinson's disease is related to increased overall mortality, but it remains unclear which patient level factors are predictive of increased mortality in Parkinson's disease. Objective: To jointly evaluate potential risk factors for overall and Parkinson's disease (PD) related mortality, we collected detailed information from a cohort of newly diagnosed PD patients which was consequently followed for over a decade. Methods: A total of 133 consecutive patients with newly diagnosed PD were followed for at least 13 years. Survival analysis of observed mortality was used to evaluate risk factors for overall mortality, whereas survival analysis of mortality as corrected for the general population was used to evaluate risk factors for PD-related mortality. Results: Overall mortality increased with age, male sex, higher levodopa equivalent dose, and presence of mild cognitive impairment. PD-related mortality increased with earlier onset of Parkinson's disease, higher levodopa equivalent dose, and mild cognitive impairment. Conclusions: Our findings provide confirmation and extension of risk factors for overall mortality and generate new insights into PD-related mortality.

Original languageEnglish
Pages (from-to)767-774
Number of pages8
JournalJournal of Parkinson's Disease
Issue number4
Publication statusPublished - 2019

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