Abstract
Context: Association between obesity and depression
has repeatedly been established. For treatment and prevention
purposes, it is important to acquire more insight
into their longitudinal interaction.
Objective: To conduct a systematic review and metaanalysis
on the longitudinal relationship between depression,
overweight, and obesity and to identify possible
influencing factors.
Data Sources: Studies were found using PubMed,
PsycINFO, and EMBASE databases and selected on several
criteria.
Study Selection: Studies examining the longitudinal
bidirectional relation between depression and overweight
(body mass index 25-29.99) or obesity (body mass
index ≥30) were selected.
Data Extraction: Unadjusted and adjusted odds ratios
(ORs) were extracted or provided by the authors.
Data Synthesis: Overall, unadjusted ORs were calculated
and subgroup analyses were performed for the 15
included studies (N=58 745) to estimate the effect of possible
moderators (sex, age, depression severity). Obesity
at baseline increased the risk of onset of depression
at follow-up (unadjusted OR, 1.55; 95% confidence interval
[CI], 1.22-1.98; Ppronounced among Americans than among Europeans
(P=.05) and for depressive disorder than for depressive
symptoms (P=.05). Overweight increased the risk of onset
of depression at follow-up (unadjusted OR, 1.27; 95%
CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)
but not among younger persons (ageddepression (symptoms and disorder) was not predictive
of overweight over time. However, depression increased
the odds for developing obesity (OR, 1.58; 95%
CI, 1.33-1.87; Pspecific moderators of the association.
Conclusions: This meta-analysis confirms a reciprocal link
between depression and obesity. Obesity was found to increasetheriskofdepression,
mostpronouncedamongAmericansandfor
clinicallydiagnoseddepression. In addition,depression
was found to be predictive of developing obesity.
has repeatedly been established. For treatment and prevention
purposes, it is important to acquire more insight
into their longitudinal interaction.
Objective: To conduct a systematic review and metaanalysis
on the longitudinal relationship between depression,
overweight, and obesity and to identify possible
influencing factors.
Data Sources: Studies were found using PubMed,
PsycINFO, and EMBASE databases and selected on several
criteria.
Study Selection: Studies examining the longitudinal
bidirectional relation between depression and overweight
(body mass index 25-29.99) or obesity (body mass
index ≥30) were selected.
Data Extraction: Unadjusted and adjusted odds ratios
(ORs) were extracted or provided by the authors.
Data Synthesis: Overall, unadjusted ORs were calculated
and subgroup analyses were performed for the 15
included studies (N=58 745) to estimate the effect of possible
moderators (sex, age, depression severity). Obesity
at baseline increased the risk of onset of depression
at follow-up (unadjusted OR, 1.55; 95% confidence interval
[CI], 1.22-1.98; Ppronounced among Americans than among Europeans
(P=.05) and for depressive disorder than for depressive
symptoms (P=.05). Overweight increased the risk of onset
of depression at follow-up (unadjusted OR, 1.27; 95%
CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)
but not among younger persons (ageddepression (symptoms and disorder) was not predictive
of overweight over time. However, depression increased
the odds for developing obesity (OR, 1.58; 95%
CI, 1.33-1.87; Pspecific moderators of the association.
Conclusions: This meta-analysis confirms a reciprocal link
between depression and obesity. Obesity was found to increasetheriskofdepression,
mostpronouncedamongAmericansandfor
clinicallydiagnoseddepression. In addition,depression
was found to be predictive of developing obesity.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 220-229 |
| Journal | Archives of General Psychiatry |
| Volume | 67 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2010 |