Abstract
has repeatedly been established. For treatment and prevention
purposes, it is important to acquire more insight
into their longitudinal interaction.
Objective: To conduct a systematic review and metaanalysis
on the longitudinal relationship between depression,
overweight, and obesity and to identify possible
influencing factors.
Data Sources: Studies were found using PubMed,
PsycINFO, and EMBASE databases and selected on several
criteria.
Study Selection: Studies examining the longitudinal
bidirectional relation between depression and overweight
(body mass index 25-29.99) or obesity (body mass
index ≥30) were selected.
Data Extraction: Unadjusted and adjusted odds ratios
(ORs) were extracted or provided by the authors.
Data Synthesis: Overall, unadjusted ORs were calculated
and subgroup analyses were performed for the 15
included studies (N=58 745) to estimate the effect of possible
moderators (sex, age, depression severity). Obesity
at baseline increased the risk of onset of depression
at follow-up (unadjusted OR, 1.55; 95% confidence interval
[CI], 1.22-1.98; Ppronounced among Americans than among Europeans
(P=.05) and for depressive disorder than for depressive
symptoms (P=.05). Overweight increased the risk of onset
of depression at follow-up (unadjusted OR, 1.27; 95%
CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)
but not among younger persons (ageddepression (symptoms and disorder) was not predictive
of overweight over time. However, depression increased
the odds for developing obesity (OR, 1.58; 95%
CI, 1.33-1.87; Pspecific moderators of the association.
Conclusions: This meta-analysis confirms a reciprocal link
between depression and obesity. Obesity was found to increasetheriskofdepression,
mostpronouncedamongAmericansandfor
clinicallydiagnoseddepression. In addition,depression
was found to be predictive of developing obesity.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 220-229 |
| Journal | Archives of General Psychiatry |
| Volume | 67 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2010 |
Cite this
}
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies. / Luppino, F.S.; de Wit, L.M.; Bouvy, P.F.; Stijnen, T.; Cuijpers, P.; Penninx, B.W.J.H.; Zitman, F.G.
In: Archives of General Psychiatry, Vol. 67, No. 3, 2010, p. 220-229.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
AU - Luppino, F.S.
AU - de Wit, L.M.
AU - Bouvy, P.F.
AU - Stijnen, T.
AU - Cuijpers, P.
AU - Penninx, B.W.J.H.
AU - Zitman, F.G.
PY - 2010
Y1 - 2010
N2 - Context: Association between obesity and depressionhas repeatedly been established. For treatment and preventionpurposes, it is important to acquire more insightinto their longitudinal interaction.Objective: To conduct a systematic review and metaanalysison the longitudinal relationship between depression,overweight, and obesity and to identify possibleinfluencing factors.Data Sources: Studies were found using PubMed,PsycINFO, and EMBASE databases and selected on severalcriteria.Study Selection: Studies examining the longitudinalbidirectional relation between depression and overweight(body mass index 25-29.99) or obesity (body massindex ≥30) were selected.Data Extraction: Unadjusted and adjusted odds ratios(ORs) were extracted or provided by the authors.Data Synthesis: Overall, unadjusted ORs were calculatedand subgroup analyses were performed for the 15included studies (N=58 745) to estimate the effect of possiblemoderators (sex, age, depression severity). Obesityat baseline increased the risk of onset of depressionat follow-up (unadjusted OR, 1.55; 95% confidence interval[CI], 1.22-1.98; Ppronounced among Americans than among Europeans(P=.05) and for depressive disorder than for depressivesymptoms (P=.05). Overweight increased the risk of onsetof depression at follow-up (unadjusted OR, 1.27; 95%CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)but not among younger persons (ageddepression (symptoms and disorder) was not predictiveof overweight over time. However, depression increasedthe odds for developing obesity (OR, 1.58; 95%CI, 1.33-1.87; Pspecific moderators of the association.Conclusions: This meta-analysis confirms a reciprocal linkbetween depression and obesity. Obesity was found to increasetheriskofdepression,mostpronouncedamongAmericansandforclinicallydiagnoseddepression. In addition,depressionwas found to be predictive of developing obesity.
AB - Context: Association between obesity and depressionhas repeatedly been established. For treatment and preventionpurposes, it is important to acquire more insightinto their longitudinal interaction.Objective: To conduct a systematic review and metaanalysison the longitudinal relationship between depression,overweight, and obesity and to identify possibleinfluencing factors.Data Sources: Studies were found using PubMed,PsycINFO, and EMBASE databases and selected on severalcriteria.Study Selection: Studies examining the longitudinalbidirectional relation between depression and overweight(body mass index 25-29.99) or obesity (body massindex ≥30) were selected.Data Extraction: Unadjusted and adjusted odds ratios(ORs) were extracted or provided by the authors.Data Synthesis: Overall, unadjusted ORs were calculatedand subgroup analyses were performed for the 15included studies (N=58 745) to estimate the effect of possiblemoderators (sex, age, depression severity). Obesityat baseline increased the risk of onset of depressionat follow-up (unadjusted OR, 1.55; 95% confidence interval[CI], 1.22-1.98; Ppronounced among Americans than among Europeans(P=.05) and for depressive disorder than for depressivesymptoms (P=.05). Overweight increased the risk of onsetof depression at follow-up (unadjusted OR, 1.27; 95%CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)but not among younger persons (ageddepression (symptoms and disorder) was not predictiveof overweight over time. However, depression increasedthe odds for developing obesity (OR, 1.58; 95%CI, 1.33-1.87; Pspecific moderators of the association.Conclusions: This meta-analysis confirms a reciprocal linkbetween depression and obesity. Obesity was found to increasetheriskofdepression,mostpronouncedamongAmericansandforclinicallydiagnoseddepression. In addition,depressionwas found to be predictive of developing obesity.
U2 - 10.1001/archgenpsychiatry.2010.2
DO - 10.1001/archgenpsychiatry.2010.2
M3 - Article
VL - 67
SP - 220
EP - 229
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
SN - 0003-990X
IS - 3
ER -