Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies

F.S. Luppino, L.M. de Wit, P.F. Bouvy, T. Stijnen, P. Cuijpers, B.W.J.H. Penninx, F.G. Zitman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Context: Association between obesity and depression
has repeatedly been established. For treatment and prevention
purposes, it is important to acquire more insight
into their longitudinal interaction.
Objective: To conduct a systematic review and metaanalysis
on the longitudinal relationship between depression,
overweight, and obesity and to identify possible
influencing factors.
Data Sources: Studies were found using PubMed,
PsycINFO, and EMBASE databases and selected on several
criteria.
Study Selection: Studies examining the longitudinal
bidirectional relation between depression and overweight
(body mass index 25-29.99) or obesity (body mass
index ≥30) were selected.
Data Extraction: Unadjusted and adjusted odds ratios
(ORs) were extracted or provided by the authors.
Data Synthesis: Overall, unadjusted ORs were calculated
and subgroup analyses were performed for the 15
included studies (N=58 745) to estimate the effect of possible
moderators (sex, age, depression severity). Obesity
at baseline increased the risk of onset of depression
at follow-up (unadjusted OR, 1.55; 95% confidence interval
[CI], 1.22-1.98; Ppronounced among Americans than among Europeans
(P=.05) and for depressive disorder than for depressive
symptoms (P=.05). Overweight increased the risk of onset
of depression at follow-up (unadjusted OR, 1.27; 95%
CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)
but not among younger persons (ageddepression (symptoms and disorder) was not predictive
of overweight over time. However, depression increased
the odds for developing obesity (OR, 1.58; 95%
CI, 1.33-1.87; Pspecific moderators of the association.
Conclusions: This meta-analysis confirms a reciprocal link
between depression and obesity. Obesity was found to increasetheriskofdepression,
mostpronouncedamongAmericansandfor
clinicallydiagnoseddepression. In addition,depression
was found to be predictive of developing obesity.
Original languageUndefined/Unknown
Pages (from-to)220-229
JournalArchives of General Psychiatry
Volume67
Issue number3
DOIs
Publication statusPublished - 2010

Cite this

Luppino, F.S. ; de Wit, L.M. ; Bouvy, P.F. ; Stijnen, T. ; Cuijpers, P. ; Penninx, B.W.J.H. ; Zitman, F.G. / Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies. In: Archives of General Psychiatry. 2010 ; Vol. 67, No. 3. pp. 220-229.
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abstract = "Context: Association between obesity and depressionhas repeatedly been established. For treatment and preventionpurposes, it is important to acquire more insightinto their longitudinal interaction.Objective: To conduct a systematic review and metaanalysison the longitudinal relationship between depression,overweight, and obesity and to identify possibleinfluencing factors.Data Sources: Studies were found using PubMed,PsycINFO, and EMBASE databases and selected on severalcriteria.Study Selection: Studies examining the longitudinalbidirectional relation between depression and overweight(body mass index 25-29.99) or obesity (body massindex ≥30) were selected.Data Extraction: Unadjusted and adjusted odds ratios(ORs) were extracted or provided by the authors.Data Synthesis: Overall, unadjusted ORs were calculatedand subgroup analyses were performed for the 15included studies (N=58 745) to estimate the effect of possiblemoderators (sex, age, depression severity). Obesityat baseline increased the risk of onset of depressionat follow-up (unadjusted OR, 1.55; 95{\%} confidence interval[CI], 1.22-1.98; Ppronounced among Americans than among Europeans(P=.05) and for depressive disorder than for depressivesymptoms (P=.05). Overweight increased the risk of onsetof depression at follow-up (unadjusted OR, 1.27; 95{\%}CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)but not among younger persons (ageddepression (symptoms and disorder) was not predictiveof overweight over time. However, depression increasedthe odds for developing obesity (OR, 1.58; 95{\%}CI, 1.33-1.87; Pspecific moderators of the association.Conclusions: This meta-analysis confirms a reciprocal linkbetween depression and obesity. Obesity was found to increasetheriskofdepression,mostpronouncedamongAmericansandforclinicallydiagnoseddepression. In addition,depressionwas found to be predictive of developing obesity.",
author = "F.S. Luppino and {de Wit}, L.M. and P.F. Bouvy and T. Stijnen and P. Cuijpers and B.W.J.H. Penninx and F.G. Zitman",
year = "2010",
doi = "10.1001/archgenpsychiatry.2010.2",
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Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies. / Luppino, F.S.; de Wit, L.M.; Bouvy, P.F.; Stijnen, T.; Cuijpers, P.; Penninx, B.W.J.H.; Zitman, F.G.

In: Archives of General Psychiatry, Vol. 67, No. 3, 2010, p. 220-229.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies

AU - Luppino, F.S.

AU - de Wit, L.M.

AU - Bouvy, P.F.

AU - Stijnen, T.

AU - Cuijpers, P.

AU - Penninx, B.W.J.H.

AU - Zitman, F.G.

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AB - Context: Association between obesity and depressionhas repeatedly been established. For treatment and preventionpurposes, it is important to acquire more insightinto their longitudinal interaction.Objective: To conduct a systematic review and metaanalysison the longitudinal relationship between depression,overweight, and obesity and to identify possibleinfluencing factors.Data Sources: Studies were found using PubMed,PsycINFO, and EMBASE databases and selected on severalcriteria.Study Selection: Studies examining the longitudinalbidirectional relation between depression and overweight(body mass index 25-29.99) or obesity (body massindex ≥30) were selected.Data Extraction: Unadjusted and adjusted odds ratios(ORs) were extracted or provided by the authors.Data Synthesis: Overall, unadjusted ORs were calculatedand subgroup analyses were performed for the 15included studies (N=58 745) to estimate the effect of possiblemoderators (sex, age, depression severity). Obesityat baseline increased the risk of onset of depressionat follow-up (unadjusted OR, 1.55; 95% confidence interval[CI], 1.22-1.98; Ppronounced among Americans than among Europeans(P=.05) and for depressive disorder than for depressivesymptoms (P=.05). Overweight increased the risk of onsetof depression at follow-up (unadjusted OR, 1.27; 95%CI, 1.07-1.51; Psignificant among adults (aged 20-59 years and≥360 years)but not among younger persons (ageddepression (symptoms and disorder) was not predictiveof overweight over time. However, depression increasedthe odds for developing obesity (OR, 1.58; 95%CI, 1.33-1.87; Pspecific moderators of the association.Conclusions: This meta-analysis confirms a reciprocal linkbetween depression and obesity. Obesity was found to increasetheriskofdepression,mostpronouncedamongAmericansandforclinicallydiagnoseddepression. In addition,depressionwas found to be predictive of developing obesity.

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DO - 10.1001/archgenpsychiatry.2010.2

M3 - Article

VL - 67

SP - 220

EP - 229

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

SN - 0003-990X

IS - 3

ER -