Oxygen-induced hypercapnia in COPD: myths and facts

Wilson F. Abdo; Leo M.A. Heunks

doi:10.1186/cc11475

Oxygen-induced hypercapnia in COPD: myths and facts

Wilson F. Abdo^*, Leo M.A. Heunks

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic

Abstract

During our medical training, we learned that oxygen administration in patients with chronic obstructive pulmonary disease (COPD) induces hypercapnia through the 'hypoxic drive' mechanism and can be dangerous. This mindset frequently results in the reluctance of clinicians to administer oxygen to hypoxemic patients with COPD. However, this fear is not based on evidence in the literature. Here, we will review the impact and pathophysiology of oxygen-induced hypercapnia in patients with acute exacerbation of COPD and recommend a titrated oxygen management.

Original language	English
Article number	323
Journal	Critical Care
Volume	16
Issue number	5
DOIs	https://doi.org/10.1186/cc11475
Publication status	Published - 29 Oct 2012

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10.1186/cc11475

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abstract = "During our medical training, we learned that oxygen administration in patients with chronic obstructive pulmonary disease (COPD) induces hypercapnia through the 'hypoxic drive' mechanism and can be dangerous. This mindset frequently results in the reluctance of clinicians to administer oxygen to hypoxemic patients with COPD. However, this fear is not based on evidence in the literature. Here, we will review the impact and pathophysiology of oxygen-induced hypercapnia in patients with acute exacerbation of COPD and recommend a titrated oxygen management.",

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AB - During our medical training, we learned that oxygen administration in patients with chronic obstructive pulmonary disease (COPD) induces hypercapnia through the 'hypoxic drive' mechanism and can be dangerous. This mindset frequently results in the reluctance of clinicians to administer oxygen to hypoxemic patients with COPD. However, this fear is not based on evidence in the literature. Here, we will review the impact and pathophysiology of oxygen-induced hypercapnia in patients with acute exacerbation of COPD and recommend a titrated oxygen management.

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Oxygen-induced hypercapnia in COPD: myths and facts

Abstract

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