Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia

Christiaan F. Mooij, Janiëlle A. E. M. van Alfen-van der Velden, Romana T. Netea-Maier, Roel ten Broek, Martin Gotthardt, Melanie M. Hagleitner

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.
Original languageEnglish
Pages (from-to)145-147
JournalJournal of Pediatric Hematology / Oncology
Volume40
Issue number2
DOIs
Publication statusPublished - 2018
Externally publishedYes

Cite this

Mooij, Christiaan F. ; van Alfen-van der Velden, Janiëlle A. E. M. ; Netea-Maier, Romana T. ; ten Broek, Roel ; Gotthardt, Martin ; Hagleitner, Melanie M. / Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. In: Journal of Pediatric Hematology / Oncology. 2018 ; Vol. 40, No. 2. pp. 145-147.
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abstract = "We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.",
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Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. / Mooij, Christiaan F.; van Alfen-van der Velden, Janiëlle A. E. M.; Netea-Maier, Romana T.; ten Broek, Roel; Gotthardt, Martin; Hagleitner, Melanie M.

In: Journal of Pediatric Hematology / Oncology, Vol. 40, No. 2, 2018, p. 145-147.

Research output: Contribution to journalArticleAcademicpeer-review

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