We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.
Mooij, C. F., van Alfen-van der Velden, J. A. E. M., Netea-Maier, R. T., ten Broek, R., Gotthardt, M., & Hagleitner, M. M. (2018). Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology / Oncology, 40(2), 145-147. https://doi.org/10.1097/MPH.0000000000000869