Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia

Christiaan F. Mooij; Janiëlle A. E. M. van Alfen-van der Velden; Romana T. Netea-Maier; Roel ten Broek; Martin Gotthardt; Melanie M. Hagleitner

doi:10.1097/MPH.0000000000000869

Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia

Christiaan F. Mooij, Janiëlle A. E. M. van Alfen-van der Velden, Romana T. Netea-Maier, Roel ten Broek, Martin Gotthardt, Melanie M. Hagleitner

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.

Original language	English
Pages (from-to)	145-147
Journal	Journal of Pediatric Hematology / Oncology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1097/MPH.0000000000000869
Publication status	Published - 2018
Externally published	Yes

Cite this

Mooij, C. F., van Alfen-van der Velden, J. A. E. M., Netea-Maier, R. T., ten Broek, R., Gotthardt, M., & Hagleitner, M. M. (2018). Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology / Oncology, 40(2), 145-147. https://doi.org/10.1097/MPH.0000000000000869

Mooij, Christiaan F. ; van Alfen-van der Velden, Janiëlle A. E. M. ; Netea-Maier, Romana T. ; ten Broek, Roel ; Gotthardt, Martin ; Hagleitner, Melanie M. / Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. In: Journal of Pediatric Hematology / Oncology. 2018 ; Vol. 40, No. 2. pp. 145-147.

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title = "Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia",

abstract = "We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.",

author = "Mooij, {Christiaan F.} and {van Alfen-van der Velden}, {Jani{\"e}lle A. E. M.} and Netea-Maier, {Romana T.} and {ten Broek}, Roel and Martin Gotthardt and Hagleitner, {Melanie M.}",

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doi = "10.1097/MPH.0000000000000869",

language = "English",

volume = "40",

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Mooij, CF, van Alfen-van der Velden, JAEM, Netea-Maier, RT, ten Broek, R, Gotthardt, M & Hagleitner, MM 2018, 'Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia', Journal of Pediatric Hematology / Oncology, vol. 40, no. 2, pp. 145-147. https://doi.org/10.1097/MPH.0000000000000869

Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. / Mooij, Christiaan F.; van Alfen-van der Velden, Janiëlle A. E. M.; Netea-Maier, Romana T.; ten Broek, Roel; Gotthardt, Martin; Hagleitner, Melanie M.

In: Journal of Pediatric Hematology / Oncology, Vol. 40, No. 2, 2018, p. 145-147.

Research output: Contribution to journal › Article › Academic › peer-review

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AB - We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.

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10.1097/MPH.0000000000000869