Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

L.K. Davis; D. Yu; C.L. Keenan; E.R. Gamazon; A.I. Konkashbaev; E.M. Derks; B.M. Neale; J. Yang; S.H. Lee; P. Evans; C.L. Barr; L. Bellodi; F. Benarroch; G.B. Berrio; O.J. Bienvenu; M.H. Bloch; R.M. Blom; R.D. Bruun; C.L. Budman; B. Camarena; D. Campbell; C. Cappi; J.C. Cardona Silgado; D.C. Cath; M.C. Cavallini; D.A. Chavira; S. Chouinard; D.V. Conti; E.H. Cook; V. Coric; B.A. Cullen; D. Deforce; R. Delorme; Y. Dion; C.K. Edlund; K. Egberts; P. Falkai; T.V. Fernandez; P.J. Gallagher; H. Garrido; D. Geller; S.L. Girard; H.J. Grabe; M.A. Grados; B.D. Greenberg; V. Gross-Tsur; S. Haddad; G.A. Heiman; S.M. Hemmings; A.G. Hounie; C. Illmann; J. Jankovic; M.A. Jenike; J.L. Kennedy; R.A. King; B. Kremeyer; R. Kurlan; N. Lanzagorta; M. Leboyer; J.F. Leckman; L. Lennertz; C. Liu; C. Lochner; T.L. Lowe; F. Macciardi; J.T. McCracken; L.M. McGrath; S.C. Mesa Restrepo; R. Moessner; J. Morgan; H. Muller; D.L. Murphy; A.L. Naarden; W.C. Ochoa; R.A. Ophoff; L. Osiecki; A.J. Pakstis; M.T. Pato; J. Piacentini; C. Pittenger; Y. Pollak; S.L. Rauch; T.J. Renner; V.I. Reus; M.A. Richter; M.A. Riddle; M.M. Robertson; R. Romero; M.C. Rosàrio; D. Rosenberg; G.A. Rouleau; S. Ruhrmann; A. Ruiz-Linares; A.S. Sampaio; J. Samuels; P. Sandor; B. Sheppard; H.S. Singer; J.H. Smit; D.J. Stein; E. Strengman; J.A. Tischfield; A.V. Valencia Duarte; H. Vallada; F. van Nieuwerburgh; J. Veenstra-Vanderweele; S. Walitza; Y. Wang; J.R. Wendland; H.G. Westenberg; Y.Y. Shugart; E.C. Miguel; W. McMahon; M. Wagner; H. Nicolini; D. Posthuma; G.L. Hanna; P. Heutink; D. Denys; P.D. Arnold; B.A. Oostra; G. Nestadt; N.B. Freimer; D.L. Pauls; N.R. Wray; S.E. Stewart; C.A. Mathews; J.A. Knowles; N.J. Cox; J.M. Scharf

doi:10.1371/journal.pgen.1003864

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

L.K. Davis, D. Yu, C.L. Keenan, E.R. Gamazon, A.I. Konkashbaev, E.M. Derks, B.M. Neale, J. Yang, S.H. Lee, P. Evans, C.L. Barr, L. Bellodi, F. Benarroch, G.B. Berrio, O.J. Bienvenu, M.H. Bloch, R.M. Blom, R.D. Bruun, C.L. Budman, B. CamarenaD. Campbell, C. Cappi, J.C. Cardona Silgado, D.C. Cath, M.C. Cavallini, D.A. Chavira, S. Chouinard, D.V. Conti, E.H. Cook, V. Coric, B.A. Cullen, D. Deforce, R. Delorme, Y. Dion, C.K. Edlund, K. Egberts, P. Falkai, T.V. Fernandez, P.J. Gallagher, H. Garrido, D. Geller, S.L. Girard, H.J. Grabe, M.A. Grados, B.D. Greenberg, V. Gross-Tsur, S. Haddad, G.A. Heiman, S.M. Hemmings, A.G. Hounie, C. Illmann, J. Jankovic, M.A. Jenike, J.L. Kennedy, R.A. King, B. Kremeyer, R. Kurlan, N. Lanzagorta, M. Leboyer, J.F. Leckman, L. Lennertz, C. Liu, C. Lochner, T.L. Lowe, F. Macciardi, J.T. McCracken, L.M. McGrath, S.C. Mesa Restrepo, R. Moessner, J. Morgan, H. Muller, D.L. Murphy, A.L. Naarden, W.C. Ochoa, R.A. Ophoff, L. Osiecki, A.J. Pakstis, M.T. Pato, J. Piacentini, C. Pittenger, Y. Pollak, S.L. Rauch, T.J. Renner, V.I. Reus, M.A. Richter, M.A. Riddle, M.M. Robertson, R. Romero, M.C. Rosàrio, D. Rosenberg, G.A. Rouleau, S. Ruhrmann, A. Ruiz-Linares, A.S. Sampaio, J. Samuels, P. Sandor, B. Sheppard, H.S. Singer, J.H. Smit, D.J. Stein, E. Strengman, J.A. Tischfield, A.V. Valencia Duarte, H. Vallada, F. van Nieuwerburgh, J. Veenstra-Vanderweele, S. Walitza, Y. Wang, J.R. Wendland, H.G. Westenberg, Y.Y. Shugart, E.C. Miguel, W. McMahon, M. Wagner, H. Nicolini, D. Posthuma, G.L. Hanna, P. Heutink, D. Denys, P.D. Arnold, B.A. Oostra, G. Nestadt, N.B. Freimer, D.L. Pauls, N.R. Wray, S.E. Stewart, C.A. Mathews, J.A. Knowles, N.J. Cox, J.M. Scharf

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	e1003864
Pages (from-to)	e1003864
Journal	PLoS Genetics
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pgen.1003864
Publication status	Published - 2013

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10.1371/journal.pgen.1003864

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Davis, L. K., Yu, D., Keenan, C. L., Gamazon, E. R., Konkashbaev, A. I., Derks, E. M., Neale, B. M., Yang, J., Lee, S. H., Evans, P., Barr, C. L., Bellodi, L., Benarroch, F., Berrio, G. B., Bienvenu, O. J., Bloch, M. H., Blom, R. M., Bruun, R. D., Budman, C. L., ... Scharf, J. M. (2013). Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genetics, 9(10), e1003864. [e1003864]. https://doi.org/10.1371/journal.pgen.1003864

Davis, L.K. ; Yu, D. ; Keenan, C.L. ; Gamazon, E.R. ; Konkashbaev, A.I. ; Derks, E.M. ; Neale, B.M. ; Yang, J. ; Lee, S.H. ; Evans, P. ; Barr, C.L. ; Bellodi, L. ; Benarroch, F. ; Berrio, G.B. ; Bienvenu, O.J. ; Bloch, M.H. ; Blom, R.M. ; Bruun, R.D. ; Budman, C.L. ; Camarena, B. ; Campbell, D. ; Cappi, C. ; Cardona Silgado, J.C. ; Cath, D.C. ; Cavallini, M.C. ; Chavira, D.A. ; Chouinard, S. ; Conti, D.V. ; Cook, E.H. ; Coric, V. ; Cullen, B.A. ; Deforce, D. ; Delorme, R. ; Dion, Y. ; Edlund, C.K. ; Egberts, K. ; Falkai, P. ; Fernandez, T.V. ; Gallagher, P.J. ; Garrido, H. ; Geller, D. ; Girard, S.L. ; Grabe, H.J. ; Grados, M.A. ; Greenberg, B.D. ; Gross-Tsur, V. ; Haddad, S. ; Heiman, G.A. ; Hemmings, S.M. ; Hounie, A.G. ; Illmann, C. ; Jankovic, J. ; Jenike, M.A. ; Kennedy, J.L. ; King, R.A. ; Kremeyer, B. ; Kurlan, R. ; Lanzagorta, N. ; Leboyer, M. ; Leckman, J.F. ; Lennertz, L. ; Liu, C. ; Lochner, C. ; Lowe, T.L. ; Macciardi, F. ; McCracken, J.T. ; McGrath, L.M. ; Mesa Restrepo, S.C. ; Moessner, R. ; Morgan, J. ; Muller, H. ; Murphy, D.L. ; Naarden, A.L. ; Ochoa, W.C. ; Ophoff, R.A. ; Osiecki, L. ; Pakstis, A.J. ; Pato, M.T. ; Piacentini, J. ; Pittenger, C. ; Pollak, Y. ; Rauch, S.L. ; Renner, T.J. ; Reus, V.I. ; Richter, M.A. ; Riddle, M.A. ; Robertson, M.M. ; Romero, R. ; Rosàrio, M.C. ; Rosenberg, D. ; Rouleau, G.A. ; Ruhrmann, S. ; Ruiz-Linares, A. ; Sampaio, A.S. ; Samuels, J. ; Sandor, P. ; Sheppard, B. ; Singer, H.S. ; Smit, J.H. ; Stein, D.J. ; Strengman, E. ; Tischfield, J.A. ; Valencia Duarte, A.V. ; Vallada, H. ; van Nieuwerburgh, F. ; Veenstra-Vanderweele, J. ; Walitza, S. ; Wang, Y. ; Wendland, J.R. ; Westenberg, H.G. ; Shugart, Y.Y. ; Miguel, E.C. ; McMahon, W. ; Wagner, M. ; Nicolini, H. ; Posthuma, D. ; Hanna, G.L. ; Heutink, P. ; Denys, D. ; Arnold, P.D. ; Oostra, B.A. ; Nestadt, G. ; Freimer, N.B. ; Pauls, D.L. ; Wray, N.R. ; Stewart, S.E. ; Mathews, C.A. ; Knowles, J.A. ; Cox, N.J. ; Scharf, J.M. / Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. In: PLoS Genetics. 2013 ; Vol. 9, No. 10. pp. e1003864.

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author = "L.K. Davis and D. Yu and C.L. Keenan and E.R. Gamazon and A.I. Konkashbaev and E.M. Derks and B.M. Neale and J. Yang and S.H. Lee and P. Evans and C.L. Barr and L. Bellodi and F. Benarroch and G.B. Berrio and O.J. Bienvenu and M.H. Bloch and R.M. Blom and R.D. Bruun and C.L. Budman and B. Camarena and D. Campbell and C. Cappi and {Cardona Silgado}, J.C. and D.C. Cath and M.C. Cavallini and D.A. Chavira and S. Chouinard and D.V. Conti and E.H. Cook and V. Coric and B.A. Cullen and D. Deforce and R. Delorme and Y. Dion and C.K. Edlund and K. Egberts and P. Falkai and T.V. Fernandez and P.J. Gallagher and H. Garrido and D. Geller and S.L. Girard and H.J. Grabe and M.A. Grados and B.D. Greenberg and V. Gross-Tsur and S. Haddad and G.A. Heiman and S.M. Hemmings and A.G. Hounie and C. Illmann and J. Jankovic and M.A. Jenike and J.L. Kennedy and R.A. King and B. Kremeyer and R. Kurlan and N. Lanzagorta and M. Leboyer and J.F. Leckman and L. Lennertz and C. Liu and C. Lochner and T.L. Lowe and F. Macciardi and J.T. McCracken and L.M. McGrath and {Mesa Restrepo}, S.C. and R. Moessner and J. Morgan and H. Muller and D.L. Murphy and A.L. Naarden and W.C. Ochoa and R.A. Ophoff and L. Osiecki and A.J. Pakstis and M.T. Pato and J. Piacentini and C. Pittenger and Y. Pollak and S.L. Rauch and T.J. Renner and V.I. Reus and M.A. Richter and M.A. Riddle and M.M. Robertson and R. Romero and M.C. Ros{\`a}rio and D. Rosenberg and G.A. Rouleau and S. Ruhrmann and A. Ruiz-Linares and A.S. Sampaio and J. Samuels and P. Sandor and B. Sheppard and H.S. Singer and J.H. Smit and D.J. Stein and E. Strengman and J.A. Tischfield and {Valencia Duarte}, A.V. and H. Vallada and {van Nieuwerburgh}, F. and J. Veenstra-Vanderweele and S. Walitza and Y. Wang and J.R. Wendland and H.G. Westenberg and Y.Y. Shugart and E.C. Miguel and W. McMahon and M. Wagner and H. Nicolini and D. Posthuma and G.L. Hanna and P. Heutink and D. Denys and P.D. Arnold and B.A. Oostra and G. Nestadt and N.B. Freimer and D.L. Pauls and N.R. Wray and S.E. Stewart and C.A. Mathews and J.A. Knowles and N.J. Cox and J.M. Scharf",

year = "2013",

doi = "10.1371/journal.pgen.1003864",

language = "English",

volume = "9",

pages = "e1003864",

journal = "PLoS Genetics",

issn = "1553-7390",

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number = "10",

}

Davis, LK, Yu, D, Keenan, CL, Gamazon, ER, Konkashbaev, AI, Derks, EM, Neale, BM, Yang, J, Lee, SH, Evans, P, Barr, CL, Bellodi, L, Benarroch, F, Berrio, GB, Bienvenu, OJ, Bloch, MH, Blom, RM, Bruun, RD, Budman, CL, Camarena, B, Campbell, D, Cappi, C, Cardona Silgado, JC, Cath, DC, Cavallini, MC, Chavira, DA, Chouinard, S, Conti, DV, Cook, EH, Coric, V, Cullen, BA, Deforce, D, Delorme, R, Dion, Y, Edlund, CK, Egberts, K, Falkai, P, Fernandez, TV, Gallagher, PJ, Garrido, H, Geller, D, Girard, SL, Grabe, HJ, Grados, MA, Greenberg, BD, Gross-Tsur, V, Haddad, S, Heiman, GA, Hemmings, SM, Hounie, AG, Illmann, C, Jankovic, J, Jenike, MA, Kennedy, JL, King, RA, Kremeyer, B, Kurlan, R, Lanzagorta, N, Leboyer, M, Leckman, JF, Lennertz, L, Liu, C, Lochner, C, Lowe, TL, Macciardi, F, McCracken, JT, McGrath, LM, Mesa Restrepo, SC, Moessner, R, Morgan, J, Muller, H, Murphy, DL, Naarden, AL, Ochoa, WC, Ophoff, RA, Osiecki, L, Pakstis, AJ, Pato, MT, Piacentini, J, Pittenger, C, Pollak, Y, Rauch, SL, Renner, TJ, Reus, VI, Richter, MA, Riddle, MA, Robertson, MM, Romero, R, Rosàrio, MC, Rosenberg, D, Rouleau, GA, Ruhrmann, S, Ruiz-Linares, A, Sampaio, AS, Samuels, J, Sandor, P, Sheppard, B, Singer, HS, Smit, JH, Stein, DJ, Strengman, E, Tischfield, JA, Valencia Duarte, AV, Vallada, H, van Nieuwerburgh, F, Veenstra-Vanderweele, J, Walitza, S, Wang, Y, Wendland, JR, Westenberg, HG, Shugart, YY, Miguel, EC, McMahon, W, Wagner, M, Nicolini, H, Posthuma, D, Hanna, GL, Heutink, P, Denys, D, Arnold, PD, Oostra, BA, Nestadt, G, Freimer, NB, Pauls, DL, Wray, NR, Stewart, SE, Mathews, CA, Knowles, JA, Cox, NJ & Scharf, JM 2013, 'Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture', PLoS Genetics, vol. 9, no. 10, e1003864, pp. e1003864. https://doi.org/10.1371/journal.pgen.1003864

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. / Davis, L.K.; Yu, D.; Keenan, C.L.; Gamazon, E.R.; Konkashbaev, A.I.; Derks, E.M.; Neale, B.M.; Yang, J.; Lee, S.H.; Evans, P.; Barr, C.L.; Bellodi, L.; Benarroch, F.; Berrio, G.B.; Bienvenu, O.J.; Bloch, M.H.; Blom, R.M.; Bruun, R.D.; Budman, C.L.; Camarena, B.; Campbell, D.; Cappi, C.; Cardona Silgado, J.C.; Cath, D.C.; Cavallini, M.C.; Chavira, D.A.; Chouinard, S.; Conti, D.V.; Cook, E.H.; Coric, V.; Cullen, B.A.; Deforce, D.; Delorme, R.; Dion, Y.; Edlund, C.K.; Egberts, K.; Falkai, P.; Fernandez, T.V.; Gallagher, P.J.; Garrido, H.; Geller, D.; Girard, S.L.; Grabe, H.J.; Grados, M.A.; Greenberg, B.D.; Gross-Tsur, V.; Haddad, S.; Heiman, G.A.; Hemmings, S.M.; Hounie, A.G.; Illmann, C.; Jankovic, J.; Jenike, M.A.; Kennedy, J.L.; King, R.A.; Kremeyer, B.; Kurlan, R.; Lanzagorta, N.; Leboyer, M.; Leckman, J.F.; Lennertz, L.; Liu, C.; Lochner, C.; Lowe, T.L.; Macciardi, F.; McCracken, J.T.; McGrath, L.M.; Mesa Restrepo, S.C.; Moessner, R.; Morgan, J.; Muller, H.; Murphy, D.L.; Naarden, A.L.; Ochoa, W.C.; Ophoff, R.A.; Osiecki, L.; Pakstis, A.J.; Pato, M.T.; Piacentini, J.; Pittenger, C.; Pollak, Y.; Rauch, S.L.; Renner, T.J.; Reus, V.I.; Richter, M.A.; Riddle, M.A.; Robertson, M.M.; Romero, R.; Rosàrio, M.C.; Rosenberg, D.; Rouleau, G.A.; Ruhrmann, S.; Ruiz-Linares, A.; Sampaio, A.S.; Samuels, J.; Sandor, P.; Sheppard, B.; Singer, H.S.; Smit, J.H.; Stein, D.J.; Strengman, E.; Tischfield, J.A.; Valencia Duarte, A.V.; Vallada, H.; van Nieuwerburgh, F.; Veenstra-Vanderweele, J.; Walitza, S.; Wang, Y.; Wendland, J.R.; Westenberg, H.G.; Shugart, Y.Y.; Miguel, E.C.; McMahon, W.; Wagner, M.; Nicolini, H.; Posthuma, D.; Hanna, G.L.; Heutink, P.; Denys, D.; Arnold, P.D.; Oostra, B.A.; Nestadt, G.; Freimer, N.B.; Pauls, D.L.; Wray, N.R.; Stewart, S.E.; Mathews, C.A.; Knowles, J.A.; Cox, N.J.; Scharf, J.M.

In: PLoS Genetics, Vol. 9, No. 10, e1003864, 2013, p. e1003864.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

AU - Davis, L.K.

AU - Yu, D.

AU - Keenan, C.L.

AU - Gamazon, E.R.

AU - Konkashbaev, A.I.

AU - Derks, E.M.

AU - Neale, B.M.

AU - Yang, J.

AU - Lee, S.H.

AU - Evans, P.

AU - Barr, C.L.

AU - Bellodi, L.

AU - Benarroch, F.

AU - Berrio, G.B.

AU - Bienvenu, O.J.

AU - Bloch, M.H.

AU - Blom, R.M.

AU - Bruun, R.D.

AU - Budman, C.L.

AU - Camarena, B.

AU - Campbell, D.

AU - Cappi, C.

AU - Cardona Silgado, J.C.

AU - Cath, D.C.

AU - Cavallini, M.C.

AU - Chavira, D.A.

AU - Chouinard, S.

AU - Conti, D.V.

AU - Cook, E.H.

AU - Coric, V.

AU - Cullen, B.A.

AU - Deforce, D.

AU - Delorme, R.

AU - Dion, Y.

AU - Edlund, C.K.

AU - Egberts, K.

AU - Falkai, P.

AU - Fernandez, T.V.

AU - Gallagher, P.J.

AU - Garrido, H.

AU - Geller, D.

AU - Girard, S.L.

AU - Grabe, H.J.

AU - Grados, M.A.

AU - Greenberg, B.D.

AU - Gross-Tsur, V.

AU - Haddad, S.

AU - Heiman, G.A.

AU - Hemmings, S.M.

AU - Hounie, A.G.

AU - Illmann, C.

AU - Jankovic, J.

AU - Jenike, M.A.

AU - Kennedy, J.L.

AU - King, R.A.

AU - Kremeyer, B.

AU - Kurlan, R.

AU - Lanzagorta, N.

AU - Leboyer, M.

AU - Leckman, J.F.

AU - Lennertz, L.

AU - Liu, C.

AU - Lochner, C.

AU - Lowe, T.L.

AU - Macciardi, F.

AU - McCracken, J.T.

AU - McGrath, L.M.

AU - Mesa Restrepo, S.C.

AU - Moessner, R.

AU - Morgan, J.

AU - Muller, H.

AU - Murphy, D.L.

AU - Naarden, A.L.

AU - Ochoa, W.C.

AU - Ophoff, R.A.

AU - Osiecki, L.

AU - Pakstis, A.J.

AU - Pato, M.T.

AU - Piacentini, J.

AU - Pittenger, C.

AU - Pollak, Y.

AU - Rauch, S.L.

AU - Renner, T.J.

AU - Reus, V.I.

AU - Richter, M.A.

AU - Riddle, M.A.

AU - Robertson, M.M.

AU - Romero, R.

AU - Rosàrio, M.C.

AU - Rosenberg, D.

AU - Rouleau, G.A.

AU - Ruhrmann, S.

AU - Ruiz-Linares, A.

AU - Sampaio, A.S.

AU - Samuels, J.

AU - Sandor, P.

AU - Sheppard, B.

AU - Singer, H.S.

AU - Smit, J.H.

AU - Stein, D.J.

AU - Strengman, E.

AU - Tischfield, J.A.

AU - Valencia Duarte, A.V.

AU - Vallada, H.

AU - van Nieuwerburgh, F.

AU - Veenstra-Vanderweele, J.

AU - Walitza, S.

AU - Wang, Y.

AU - Wendland, J.R.

AU - Westenberg, H.G.

AU - Shugart, Y.Y.

AU - Miguel, E.C.

AU - McMahon, W.

AU - Wagner, M.

AU - Nicolini, H.

AU - Posthuma, D.

AU - Hanna, G.L.

AU - Heutink, P.

AU - Denys, D.

AU - Arnold, P.D.

AU - Oostra, B.A.

AU - Nestadt, G.

AU - Freimer, N.B.

AU - Pauls, D.L.

AU - Wray, N.R.

AU - Stewart, S.E.

AU - Mathews, C.A.

AU - Knowles, J.A.

AU - Cox, N.J.

AU - Scharf, J.M.

PY - 2013

Y1 - 2013

U2 - 10.1371/journal.pgen.1003864

DO - 10.1371/journal.pgen.1003864

M3 - Article

C2 - 24204291

VL - 9

SP - e1003864

JO - PLoS Genetics

JF - PLoS Genetics

SN - 1553-7390

IS - 10

M1 - e1003864

ER -