Pathological differences between white and grey matter multiple sclerosis lesions

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Multiple sclerosis (MS) is a debilitating disease characterized by demyelination of the central nervous system (CNS), resulting in widespread formation of white matter lesions (WMLs) and grey matter lesions (GMLs). WMLs are pathologically characterized by the presence of immune cells that infiltrate the CNS, whereas these immune cells are barely present in GMLs. This striking pathological difference between WMLs and GMLs raises questions about the underlying mechanism. It is known that infiltrating leukocytes contribute to the generation of WMLs; however, since GMLs show a paucity of infiltrating immune cells, their importance in GML formation remains to be determined. Here, we review pathological characteristics of WMLs and GMLs, and suggest some possible explanations for the observed pathological differences. In our view, cellular and molecular characteristics of WM and GM, and local differences within WMLs and GMLs (in particular, in glial cell populations and the molecules they express), determine the pathway to demyelination. Further understanding of GML pathogenesis, considered to contribute to chronic MS, may have a direct impact on the development of novel therapeutic targets to counteract this progressive neurological disorder.

Original languageEnglish
Pages (from-to)99-113
Number of pages15
JournalAnnals of the New York Academy of Sciences
Volume1351
DOIs
Publication statusPublished - Sep 2015

Cite this

@article{6e6cde33d59a49b2b506fd2a3b9d1cf7,
title = "Pathological differences between white and grey matter multiple sclerosis lesions",
abstract = "Multiple sclerosis (MS) is a debilitating disease characterized by demyelination of the central nervous system (CNS), resulting in widespread formation of white matter lesions (WMLs) and grey matter lesions (GMLs). WMLs are pathologically characterized by the presence of immune cells that infiltrate the CNS, whereas these immune cells are barely present in GMLs. This striking pathological difference between WMLs and GMLs raises questions about the underlying mechanism. It is known that infiltrating leukocytes contribute to the generation of WMLs; however, since GMLs show a paucity of infiltrating immune cells, their importance in GML formation remains to be determined. Here, we review pathological characteristics of WMLs and GMLs, and suggest some possible explanations for the observed pathological differences. In our view, cellular and molecular characteristics of WM and GM, and local differences within WMLs and GMLs (in particular, in glial cell populations and the molecules they express), determine the pathway to demyelination. Further understanding of GML pathogenesis, considered to contribute to chronic MS, may have a direct impact on the development of novel therapeutic targets to counteract this progressive neurological disorder.",
keywords = "Astrocytes, Blood-Brain Barrier, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Demyelinating Diseases, Gray Matter, Humans, Inflammation, Leukoencephalopathies, Microglia, Multiple Sclerosis, White Matter, Journal Article, Review",
author = "Marloes Prins and Emma Schul and Jeroen Geurts and {van der Valk}, Paul and Benjamin Drukarch and {van Dam}, Anne-Marie",
note = "{\circledC} 2015 New York Academy of Sciences.",
year = "2015",
month = "9",
doi = "10.1111/nyas.12841",
language = "English",
volume = "1351",
pages = "99--113",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

Pathological differences between white and grey matter multiple sclerosis lesions. / Prins, Marloes; Schul, Emma; Geurts, Jeroen; van der Valk, Paul; Drukarch, Benjamin; van Dam, Anne-Marie.

In: Annals of the New York Academy of Sciences, Vol. 1351, 09.2015, p. 99-113.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Pathological differences between white and grey matter multiple sclerosis lesions

AU - Prins, Marloes

AU - Schul, Emma

AU - Geurts, Jeroen

AU - van der Valk, Paul

AU - Drukarch, Benjamin

AU - van Dam, Anne-Marie

N1 - © 2015 New York Academy of Sciences.

PY - 2015/9

Y1 - 2015/9

N2 - Multiple sclerosis (MS) is a debilitating disease characterized by demyelination of the central nervous system (CNS), resulting in widespread formation of white matter lesions (WMLs) and grey matter lesions (GMLs). WMLs are pathologically characterized by the presence of immune cells that infiltrate the CNS, whereas these immune cells are barely present in GMLs. This striking pathological difference between WMLs and GMLs raises questions about the underlying mechanism. It is known that infiltrating leukocytes contribute to the generation of WMLs; however, since GMLs show a paucity of infiltrating immune cells, their importance in GML formation remains to be determined. Here, we review pathological characteristics of WMLs and GMLs, and suggest some possible explanations for the observed pathological differences. In our view, cellular and molecular characteristics of WM and GM, and local differences within WMLs and GMLs (in particular, in glial cell populations and the molecules they express), determine the pathway to demyelination. Further understanding of GML pathogenesis, considered to contribute to chronic MS, may have a direct impact on the development of novel therapeutic targets to counteract this progressive neurological disorder.

AB - Multiple sclerosis (MS) is a debilitating disease characterized by demyelination of the central nervous system (CNS), resulting in widespread formation of white matter lesions (WMLs) and grey matter lesions (GMLs). WMLs are pathologically characterized by the presence of immune cells that infiltrate the CNS, whereas these immune cells are barely present in GMLs. This striking pathological difference between WMLs and GMLs raises questions about the underlying mechanism. It is known that infiltrating leukocytes contribute to the generation of WMLs; however, since GMLs show a paucity of infiltrating immune cells, their importance in GML formation remains to be determined. Here, we review pathological characteristics of WMLs and GMLs, and suggest some possible explanations for the observed pathological differences. In our view, cellular and molecular characteristics of WM and GM, and local differences within WMLs and GMLs (in particular, in glial cell populations and the molecules they express), determine the pathway to demyelination. Further understanding of GML pathogenesis, considered to contribute to chronic MS, may have a direct impact on the development of novel therapeutic targets to counteract this progressive neurological disorder.

KW - Astrocytes

KW - Blood-Brain Barrier

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Demyelinating Diseases

KW - Gray Matter

KW - Humans

KW - Inflammation

KW - Leukoencephalopathies

KW - Microglia

KW - Multiple Sclerosis

KW - White Matter

KW - Journal Article

KW - Review

U2 - 10.1111/nyas.12841

DO - 10.1111/nyas.12841

M3 - Review article

VL - 1351

SP - 99

EP - 113

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -