Patient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor

G van der Werf, F H Menko, J J Gille, P J van Diest, C J van Groeningen

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.

Translated title of the contributionPatient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor
Original languageDutch
Pages (from-to)667-70
Number of pages4
JournalNederlands Tijdschrift voor Geneeskunde
Volume144
Issue number14
Publication statusPublished - 1 Apr 2000

Cite this

van der Werf, G., Menko, F. H., Gille, J. J., van Diest, P. J., & van Groeningen, C. J. (2000). Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor. Nederlands Tijdschrift voor Geneeskunde, 144(14), 667-70.
van der Werf, G ; Menko, F H ; Gille, J J ; van Diest, P J ; van Groeningen, C J. / Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor. In: Nederlands Tijdschrift voor Geneeskunde. 2000 ; Vol. 144, No. 14. pp. 667-70.
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title = "Een pati{\"e}nt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor",
abstract = "In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.",
keywords = "Adenocarcinoma/etiology, Adult, Genetic Predisposition to Disease, Hamartoma/etiology, Humans, Intestinal Neoplasms/etiology, Liver Neoplasms/etiology, Male, Neoplasms, Unknown Primary/genetics, Peutz-Jeghers Syndrome/complications, Thrombophlebitis/etiology",
author = "{van der Werf}, G and Menko, {F H} and Gille, {J J} and {van Diest}, {P J} and {van Groeningen}, {C J}",
year = "2000",
month = "4",
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language = "Dutch",
volume = "144",
pages = "667--70",
journal = "Nederlands Tijdschrift voor Geneeskunde",
issn = "0028-2162",
publisher = "Bohn Stafleu van Loghum",
number = "14",

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van der Werf, G, Menko, FH, Gille, JJ, van Diest, PJ & van Groeningen, CJ 2000, 'Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor' Nederlands Tijdschrift voor Geneeskunde, vol. 144, no. 14, pp. 667-70.

Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor. / van der Werf, G; Menko, F H; Gille, J J; van Diest, P J; van Groeningen, C J.

In: Nederlands Tijdschrift voor Geneeskunde, Vol. 144, No. 14, 01.04.2000, p. 667-70.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor

AU - van der Werf, G

AU - Menko, F H

AU - Gille, J J

AU - van Diest, P J

AU - van Groeningen, C J

PY - 2000/4/1

Y1 - 2000/4/1

N2 - In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.

AB - In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.

KW - Adenocarcinoma/etiology

KW - Adult

KW - Genetic Predisposition to Disease

KW - Hamartoma/etiology

KW - Humans

KW - Intestinal Neoplasms/etiology

KW - Liver Neoplasms/etiology

KW - Male

KW - Neoplasms, Unknown Primary/genetics

KW - Peutz-Jeghers Syndrome/complications

KW - Thrombophlebitis/etiology

M3 - Review article

VL - 144

SP - 667

EP - 670

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

SN - 0028-2162

IS - 14

ER -