Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease

Andrew T Reid, Anouk G W van Norden, Karlijn F de Laat, Lucas J B van Oudheusden, Marcel P Zwiers, Alan C Evans, Frank-Erik de Leeuw, Rolf Kötter

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Emerging noninvasive neuroimaging techniques allow for the morphometric analysis of patterns of gray and white matter degeneration in vivo, which may help explain and predict the occurrence of cognitive impairment and Alzheimer's disease. A single center prospective follow-up study (Radboud University Nijmegen Diffusion tensor and Magnetic resonance imaging Cohort study (RUN DMC)) was performed involving 503 nondemented elderly individuals (50-85 years) with a history of symptomatic cerebral small vessel disease (SVD). Age was associated with a global reduction in cortical thickness, and this relationship was strongest for ventrolateral prefrontal cortex, auditory cortex, Wernicke's area, superior temporal lobe, and primary visual cortex. Right and left hemispheres differed in the thickness of language-related areas. White matter (WM) lesions were generally negatively correlated with cortical thickness, primarily in individuals over the age of 60, with the notable exception of Brodmann areas 4 and 5, which were positively correlated in age groups 50-60 and 60-70, respectively. The observed pattern of age-related decline may explain problems in memory and executive functions, which are already well documented in individuals with SVD. The additional gray matter loss affecting visual and auditory cortex, and specifically the head region of primary motor cortex, may indicate morphological correlates of impaired sensory and motor functions. The paradoxical positive relationship between WM lesion volume and cortical thickness in some areas may reflect early compensatory hypertrophy. This study raises a further interest in the mechanisms underlying cerebral gray and white matter degeneration in association with SVD, which will require further investigation with diffusion weighted and longitudinal MR studies.

Original languageEnglish
Pages (from-to)1983-92
Number of pages10
JournalHuman Brain Mapping
Volume31
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Cite this

Reid, A. T., van Norden, A. G. W., de Laat, K. F., van Oudheusden, L. J. B., Zwiers, M. P., Evans, A. C., ... Kötter, R. (2010). Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease. Human Brain Mapping, 31(12), 1983-92. https://doi.org/10.1002/hbm.20994
Reid, Andrew T ; van Norden, Anouk G W ; de Laat, Karlijn F ; van Oudheusden, Lucas J B ; Zwiers, Marcel P ; Evans, Alan C ; de Leeuw, Frank-Erik ; Kötter, Rolf. / Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease. In: Human Brain Mapping. 2010 ; Vol. 31, No. 12. pp. 1983-92.
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Reid, AT, van Norden, AGW, de Laat, KF, van Oudheusden, LJB, Zwiers, MP, Evans, AC, de Leeuw, F-E & Kötter, R 2010, 'Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease' Human Brain Mapping, vol. 31, no. 12, pp. 1983-92. https://doi.org/10.1002/hbm.20994

Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease. / Reid, Andrew T; van Norden, Anouk G W; de Laat, Karlijn F; van Oudheusden, Lucas J B; Zwiers, Marcel P; Evans, Alan C; de Leeuw, Frank-Erik; Kötter, Rolf.

In: Human Brain Mapping, Vol. 31, No. 12, 12.2010, p. 1983-92.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease

AU - Reid, Andrew T

AU - van Norden, Anouk G W

AU - de Laat, Karlijn F

AU - van Oudheusden, Lucas J B

AU - Zwiers, Marcel P

AU - Evans, Alan C

AU - de Leeuw, Frank-Erik

AU - Kötter, Rolf

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N2 - Emerging noninvasive neuroimaging techniques allow for the morphometric analysis of patterns of gray and white matter degeneration in vivo, which may help explain and predict the occurrence of cognitive impairment and Alzheimer's disease. A single center prospective follow-up study (Radboud University Nijmegen Diffusion tensor and Magnetic resonance imaging Cohort study (RUN DMC)) was performed involving 503 nondemented elderly individuals (50-85 years) with a history of symptomatic cerebral small vessel disease (SVD). Age was associated with a global reduction in cortical thickness, and this relationship was strongest for ventrolateral prefrontal cortex, auditory cortex, Wernicke's area, superior temporal lobe, and primary visual cortex. Right and left hemispheres differed in the thickness of language-related areas. White matter (WM) lesions were generally negatively correlated with cortical thickness, primarily in individuals over the age of 60, with the notable exception of Brodmann areas 4 and 5, which were positively correlated in age groups 50-60 and 60-70, respectively. The observed pattern of age-related decline may explain problems in memory and executive functions, which are already well documented in individuals with SVD. The additional gray matter loss affecting visual and auditory cortex, and specifically the head region of primary motor cortex, may indicate morphological correlates of impaired sensory and motor functions. The paradoxical positive relationship between WM lesion volume and cortical thickness in some areas may reflect early compensatory hypertrophy. This study raises a further interest in the mechanisms underlying cerebral gray and white matter degeneration in association with SVD, which will require further investigation with diffusion weighted and longitudinal MR studies.

AB - Emerging noninvasive neuroimaging techniques allow for the morphometric analysis of patterns of gray and white matter degeneration in vivo, which may help explain and predict the occurrence of cognitive impairment and Alzheimer's disease. A single center prospective follow-up study (Radboud University Nijmegen Diffusion tensor and Magnetic resonance imaging Cohort study (RUN DMC)) was performed involving 503 nondemented elderly individuals (50-85 years) with a history of symptomatic cerebral small vessel disease (SVD). Age was associated with a global reduction in cortical thickness, and this relationship was strongest for ventrolateral prefrontal cortex, auditory cortex, Wernicke's area, superior temporal lobe, and primary visual cortex. Right and left hemispheres differed in the thickness of language-related areas. White matter (WM) lesions were generally negatively correlated with cortical thickness, primarily in individuals over the age of 60, with the notable exception of Brodmann areas 4 and 5, which were positively correlated in age groups 50-60 and 60-70, respectively. The observed pattern of age-related decline may explain problems in memory and executive functions, which are already well documented in individuals with SVD. The additional gray matter loss affecting visual and auditory cortex, and specifically the head region of primary motor cortex, may indicate morphological correlates of impaired sensory and motor functions. The paradoxical positive relationship between WM lesion volume and cortical thickness in some areas may reflect early compensatory hypertrophy. This study raises a further interest in the mechanisms underlying cerebral gray and white matter degeneration in association with SVD, which will require further investigation with diffusion weighted and longitudinal MR studies.

KW - Aged

KW - Aged, 80 and over

KW - Aging/pathology

KW - Atrophy/etiology

KW - Cerebral Cortex/blood supply

KW - Cerebrovascular Disorders/pathology

KW - Cohort Studies

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Nerve Degeneration/etiology

KW - Prospective Studies

U2 - 10.1002/hbm.20994

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ER -