Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals

ALFA Study

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and regional distribution of WMH on episodic memory and executive function in middle-aged cognitively unimpaired participants [N = 561 (45–75 years)] enriched for Alzheimer’s disease risk factors. WMH were automatically segmented from FLAIR, T1 and FSE MR images. WMH load was calculated both globally and regionally. At each cerebral lobe, regional WMH load was measured at four equidistant layers extending from the lateral ventricles to juxtacortical areas. Cognition was measured by The Memory Binding Test (MBT) and WAIS-IV subtests. Global composite z-scores were calculated for the two cognitive domains. Association between global and regional WMH measurements were sought against cognitive measures, both in global composite scores and in individual subtests. We adjusted cognition and WMH burden for the main sociodemographic (age, sex and education) and genetic factors (APOE-ε4). Memory and executive function were significantly associated with global WMH load. Regionally, lower executive performance was mainly associated with higher deep WMH load in frontal areas and, to a lower degree, in occipital, parietal and temporal regions. Lower episodic memory performance was correlated with higher WMH burden in deep frontal and occipital areas. Our novel methodological approach of regional analysis allowed us to reveal the association between cognition and WMH in strategic brain locations. Our results suggest that, even a small WMH load can impact cognition in cognitively unimpaired middle-aged subjects.
Original languageEnglish
JournalBrain Imaging and Behavior
Early online date5 Jul 2019
DOIs
Publication statusPublished - 2019

Cite this

@article{e71e533609174e9793e1785ffa315a10,
title = "Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals",
abstract = "White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and regional distribution of WMH on episodic memory and executive function in middle-aged cognitively unimpaired participants [N = 561 (45–75 years)] enriched for Alzheimer’s disease risk factors. WMH were automatically segmented from FLAIR, T1 and FSE MR images. WMH load was calculated both globally and regionally. At each cerebral lobe, regional WMH load was measured at four equidistant layers extending from the lateral ventricles to juxtacortical areas. Cognition was measured by The Memory Binding Test (MBT) and WAIS-IV subtests. Global composite z-scores were calculated for the two cognitive domains. Association between global and regional WMH measurements were sought against cognitive measures, both in global composite scores and in individual subtests. We adjusted cognition and WMH burden for the main sociodemographic (age, sex and education) and genetic factors (APOE-ε4). Memory and executive function were significantly associated with global WMH load. Regionally, lower executive performance was mainly associated with higher deep WMH load in frontal areas and, to a lower degree, in occipital, parietal and temporal regions. Lower episodic memory performance was correlated with higher WMH burden in deep frontal and occipital areas. Our novel methodological approach of regional analysis allowed us to reveal the association between cognition and WMH in strategic brain locations. Our results suggest that, even a small WMH load can impact cognition in cognitively unimpaired middle-aged subjects.",
author = "Anna Brugulat-Serrat and Gemma Salvad{\'o} and Sudre, {Carole H.} and Oriol Grau-Rivera and Marc Su{\'a}rez-Calvet and Carles Falcon and Gonzalo S{\'a}nchez-Benavides and Nina Gramunt and Karine Fauria and Cardoso, {M. Jorge} and Frederik Barkhof and Molinuevo, {Jos{\'e} Luis} and Gispert, {Juan Domingo} and {ALFA Study} and Jordi Cam{\'i} and Raffaele Cacciaglia and Gr{\'e}gory Operto and Stavros Skouras and Carolina Minguill{\'o}n and Albina Polo and Cristina Mustata and Laia Tenas and Paula Marne and Xavi Gotsens and Tania Mench{\'o}n and Anna Soteras and Laura Hernandez and Ruth Dominguez and Sandra Pradas and Gema Huesa and Marc Vilanova and Sabrina Segundo and Jordi Huguet",
year = "2019",
doi = "10.1007/s11682-019-00151-2",
language = "English",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",

}

Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals. / ALFA Study.

In: Brain Imaging and Behavior, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals

AU - Brugulat-Serrat, Anna

AU - Salvadó, Gemma

AU - Sudre, Carole H.

AU - Grau-Rivera, Oriol

AU - Suárez-Calvet, Marc

AU - Falcon, Carles

AU - Sánchez-Benavides, Gonzalo

AU - Gramunt, Nina

AU - Fauria, Karine

AU - Cardoso, M. Jorge

AU - Barkhof, Frederik

AU - Molinuevo, José Luis

AU - Gispert, Juan Domingo

AU - ALFA Study

AU - Camí, Jordi

AU - Cacciaglia, Raffaele

AU - Operto, Grégory

AU - Skouras, Stavros

AU - Minguillón, Carolina

AU - Polo, Albina

AU - Mustata, Cristina

AU - Tenas, Laia

AU - Marne, Paula

AU - Gotsens, Xavi

AU - Menchón, Tania

AU - Soteras, Anna

AU - Hernandez, Laura

AU - Dominguez, Ruth

AU - Pradas, Sandra

AU - Huesa, Gema

AU - Vilanova, Marc

AU - Segundo, Sabrina

AU - Huguet, Jordi

PY - 2019

Y1 - 2019

N2 - White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and regional distribution of WMH on episodic memory and executive function in middle-aged cognitively unimpaired participants [N = 561 (45–75 years)] enriched for Alzheimer’s disease risk factors. WMH were automatically segmented from FLAIR, T1 and FSE MR images. WMH load was calculated both globally and regionally. At each cerebral lobe, regional WMH load was measured at four equidistant layers extending from the lateral ventricles to juxtacortical areas. Cognition was measured by The Memory Binding Test (MBT) and WAIS-IV subtests. Global composite z-scores were calculated for the two cognitive domains. Association between global and regional WMH measurements were sought against cognitive measures, both in global composite scores and in individual subtests. We adjusted cognition and WMH burden for the main sociodemographic (age, sex and education) and genetic factors (APOE-ε4). Memory and executive function were significantly associated with global WMH load. Regionally, lower executive performance was mainly associated with higher deep WMH load in frontal areas and, to a lower degree, in occipital, parietal and temporal regions. Lower episodic memory performance was correlated with higher WMH burden in deep frontal and occipital areas. Our novel methodological approach of regional analysis allowed us to reveal the association between cognition and WMH in strategic brain locations. Our results suggest that, even a small WMH load can impact cognition in cognitively unimpaired middle-aged subjects.

AB - White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and regional distribution of WMH on episodic memory and executive function in middle-aged cognitively unimpaired participants [N = 561 (45–75 years)] enriched for Alzheimer’s disease risk factors. WMH were automatically segmented from FLAIR, T1 and FSE MR images. WMH load was calculated both globally and regionally. At each cerebral lobe, regional WMH load was measured at four equidistant layers extending from the lateral ventricles to juxtacortical areas. Cognition was measured by The Memory Binding Test (MBT) and WAIS-IV subtests. Global composite z-scores were calculated for the two cognitive domains. Association between global and regional WMH measurements were sought against cognitive measures, both in global composite scores and in individual subtests. We adjusted cognition and WMH burden for the main sociodemographic (age, sex and education) and genetic factors (APOE-ε4). Memory and executive function were significantly associated with global WMH load. Regionally, lower executive performance was mainly associated with higher deep WMH load in frontal areas and, to a lower degree, in occipital, parietal and temporal regions. Lower episodic memory performance was correlated with higher WMH burden in deep frontal and occipital areas. Our novel methodological approach of regional analysis allowed us to reveal the association between cognition and WMH in strategic brain locations. Our results suggest that, even a small WMH load can impact cognition in cognitively unimpaired middle-aged subjects.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068877065&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31278650

U2 - 10.1007/s11682-019-00151-2

DO - 10.1007/s11682-019-00151-2

M3 - Article

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

ER -